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Drug-tubulin interactions interrogated by transient absorption spectroscopy

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Drug-tubulin interactions interrogated by transient absorption spectroscopy

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Bosca Mayans, F.; Sastre Navarro, GI.; Andreu, JM.; Jornet, D.; Tormos Faus, RE.; Miranda Alonso, MÁ. (2015). Drug-tubulin interactions interrogated by transient absorption spectroscopy. RSC Advances. 5(61):49451-49458. https://doi.org/10.1039/C5RA05636E

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Título: Drug-tubulin interactions interrogated by transient absorption spectroscopy
Autor: Bosca Mayans, Francisco Sastre Navarro, German Ignacio Andreu, José María Jornet, David Tormos Faus, Rosa Esperanza Miranda Alonso, Miguel Ángel
Entidad UPV: Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química
Universitat Politècnica de València. Departamento de Química - Departament de Química
Fecha difusión:
Resumen:
[EN] Colchicine (COL) is a bioactive molecule with antitumor properties. When COL binds to tubulin (TU), it inhibits microtubule assembly dynamics. We have investigated COL-TU interactions using laser flash photolysis (LFP) ...[+]
Palabras clave: Colchicine site inhibitors , Fluorescence stopped-flow , Molecular-dynamics , Anticancer drugs , Binding-site , Analogs , Ring , Complex , Lumicolchicines , Polymerization
Derechos de uso: Reserva de todos los derechos
Fuente:
RSC Advances. (issn: 2046-2069 )
DOI: 10.1039/C5RA05636E
Editorial:
Royal Society of Chemistry
Versión del editor: http://doi.org/10.1039/c5ra05636e
Código del Proyecto:
info:eu-repo/grantAgreement/MICINN//CTQ2010-19909/ES/MECANISMOS IMPLICADOS EN LA FOTO-REACTIVIDAD ENTRE FARMACOS CON PROPIEDADES ANTINEOPLASICAS Y SUS BIOMOLECULAS DIANA/
info:eu-repo/grantAgreement/GVA//PROMETEOII%2F2013%2F005/ES/ESPECIES FOTOACTIVAS Y SU INTERACCION CON BIOMOLECULAS/
info:eu-repo/grantAgreement/CAM//S2010%2FBMD-2353/
info:eu-repo/grantAgreement/MICINN//BFU2011-23416/ES/INHIBICION FUNCIONAL DE LA PROTEINA DE DIVISION CELULAR FTSZ Y ENSAMBLAJE DE NUEVAS TUBULINAS/
info:eu-repo/grantAgreement/MINECO//SEV-2012-0267/
Agradecimientos:
Financial support from the Spanish Government (grants CTQ2010-19909; BFU2011-23416 and SEV 2012-0267), the Generalitat Valenciana (Prometeo II/2013/005) and Comunidad de Madrid (S2010/BMD-2353) is gratefully acknowledged. ...[+]
Tipo: Artículo

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