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Drug-tubulin interactions interrogated by transient absorption spectroscopy

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Drug-tubulin interactions interrogated by transient absorption spectroscopy

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Bosca Mayans, F.; Sastre Navarro, GI.; Andreu, JM.; Jornet, D.; Tormos Faus, RE.; Miranda Alonso, MÁ. (2015). Drug-tubulin interactions interrogated by transient absorption spectroscopy. RSC Advances. 5(61):49451-49458. doi:10.1039/C5RA05636E.

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/88053

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Title: Drug-tubulin interactions interrogated by transient absorption spectroscopy
Author:
UPV Unit: Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química
Universitat Politècnica de València. Departamento de Química - Departament de Química
Issued date:
Abstract:
[EN] Colchicine (COL) is a bioactive molecule with antitumor properties. When COL binds to tubulin (TU), it inhibits microtubule assembly dynamics. We have investigated COL-TU interactions using laser flash photolysis (LFP) ...[+]
Subjects: Colchicine site inhibitors , Fluorescence stopped-flow , Molecular-dynamics , Anticancer drugs , Binding-site , Analogs , Ring , Complex , Lumicolchicines , Polymerization
Copyrigths: Reserva de todos los derechos
Source:
RSC Advances. (issn: 2046-2069 )
DOI: 10.1039/C5RA05636E
Publisher:
Royal Society of Chemistry
Publisher version: http://doi.org/10.1039/c5ra05636e
Thanks:
Financial support from the Spanish Government (grants CTQ2010-19909; BFU2011-23416 and SEV 2012-0267), the Generalitat Valenciana (Prometeo II/2013/005) and Comunidad de Madrid (S2010/BMD-2353) is gratefully acknowledged. ...[+]
Type: Artículo

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