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Metabolic adaptations in neonatal mother-deprived rabbits

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Metabolic adaptations in neonatal mother-deprived rabbits

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dc.contributor.author Brecchia, Gabriele
dc.contributor.author Zerani, Massimo
dc.contributor.author Bonano, Adriana
dc.contributor.author Boiti, Cristiano
dc.date.accessioned 2011-01-12T16:51:49Z
dc.date.available 2012-12-12T23:30:21Z
dc.date.issued 2010-12-30
dc.identifier.issn 1257-5011
dc.identifier.uri http://hdl.handle.net/10251/9144
dc.description.abstract [EN] In order to study the metabolic adaptation in response to 48 h transient doe-litter separation (DLS) in young rabbits (5 rabbits/d group) between postnatal 9 and 11 d, plasma concentrations of thyroid hormones T3 and T4, insulin, leptin, glucose, triglycerides (TG), and free fatty acids (FFA) were examined before (6-8 d), during (9-11 d), and after separation (12-16 d). T3 concentrations in newborn control rabbits gradually increased from 0.6 ng/mL at postnatal 6 d to 1.0 ng/mL at postnatal 16 d, whereas those of T4 remained fairly constant (25 ng/mL) up to postnatal 14 d, when T4 gradually declined to 8 ng/mL. T3 values of DLS newborn rabbits did not differ from those of controls at postnatal 10 and 11 d, but were lower (P<0.05) at postnatal 12 d, while T4 concentrations in DLS animals increased, although not significantly, between postnatal 10 and 12 d compared to controls. Insulin concentrations in young control rabbits ranged between 0.6 and 1.0 mg/L in the early postnatal days, whereas those for leptin averaged 2-3 ng/mL. Insulin and leptin values in DLS newborn rabbits were lower (P<0.05) at postnatal 10 and 11 d, but thereafter rebounded to levels close to those of controls. Glycaemia showed a comparable trend in both groups, ranging between 170 and 190 mg/dL up to postnatal 14 d, but thereafter decreased (P<0.05) to values of 120-130 mg/dL independently of treatment. Concentrations of TG varied greatly from day to day around a mean value of 300 mg/dL, whereas those of FFA remained at approximately the same steady-state levels from postnatal 6 to 16 d, averaging 0.8 mM without any significant differences between groups. In conclusion, these findings confirm that newborn rabbits can cope with the metabolic stress of starvation associated with DLS by lowering insulin and leptin concentrations while maintaining those of thyroid hormones, an overall endocrine response which, together with temporary increase of glucorticoids, successfully maintains an adequate energy balance. es_ES
dc.description.sponsorship This work was partially supported by a grant from the Italian “Ministero Istruzione Università e Ricerca” (Progetto Ricerca Interesse Nazionale – Prot. 2001072484 and 2003074002) and by generous donations from the BC Red-water Trust (Perugia, Italy). Procedures conformed to animal care guidelines and were approved by the Bioethical Committee of the University of Perugia in accordance with the current laws of Italy. The authors gratefully acknowledge the revision of the English text by Sheila Beatty.
dc.language Inglés es_ES
dc.publisher World Rabbit Science. ICTA. UPV es_ES
dc.relation.ispartof World Rabbit Science
dc.rights Reserva de todos los derechos es_ES
dc.subject Maternal separation es_ES
dc.subject Thyroid hormones es_ES
dc.subject Insulin es_ES
dc.subject Leptin es_ES
dc.subject Glucose es_ES
dc.subject Rabbit es_ES
dc.title Metabolic adaptations in neonatal mother-deprived rabbits es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.4995/wrs.2010.780
dc.relation.projectID info:eu-repo/grantAgreement/MIUR//2001072484/
dc.relation.projectID info:eu-repo/grantAgreement/MIUR//2003074002/
dc.rights.accessRights Abierto es_ES
dc.description.bibliographicCitation Brecchia, G.; Zerani, M.; Bonano, A.; Boiti, C. (2010). Metabolic adaptations in neonatal mother-deprived rabbits. World Rabbit Science. 18(4):229-236. https://doi.org/10.4995/wrs.2010.780 es_ES
dc.relation.publisherversion https://doi.org/10.4995/wrs.2010.780
dc.description.upvformatpinicio 229
dc.description.upvformatpfin 236
dc.description.volume 18
dc.description.issue 4
dc.identifier.eissn 1989-8886
dc.contributor.funder Ministero dell'Istruzione dell'Università e della Ricerca, Italia


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