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Teratogenic effects of ochratoxin a in rabbits

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Teratogenic effects of ochratoxin a in rabbits

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dc.contributor.author Wangikar, P.B.
dc.contributor.author Dwivedi, P.
dc.contributor.author Sinha, N.
dc.date.accessioned 2011-02-14T11:52:23Z
dc.date.available 2011-02-14T11:52:23Z
dc.date.issued 2004
dc.identifier.issn 1257-5011
dc.identifier.uri http://hdl.handle.net/10251/9786
dc.description.abstract [EN] Ochratoxin A, is a food-borne mycotoxin produced by several fungal species of the genera Aspergillus and Penicillium. Ochratoxin A was dissolved in corn oil and given by gastric intubation to rabbits on days 6-18 of gestation with the dose levels of 0.025, 0.050 and 0.100 mg/kg body weight. When compared with controls (4.16 %), in case of 0.100 mg/kg dose group, there was a significant increase in the incidence of gross (P<0.05) and skeletal (P<0.10) anomalies. The number of live fetuses in the case of 0.100 mg/kg dose group was significantly less than those of the 0.025mg/kg dose group. When compared to controls and 0.025mg/kg dose group, the mean fetal weights and mean fetal crown to rump lengths of dose group 0.100 mg/kg were significantly lower. Major gross anomalies caused by ochratoxin A included wrist drop, rudimentary tail, knuckling of fetlock and agenesis of tail. Skeletal anomalies were agenesis of caudal vertebrae, incomplete ossification of skull bones and wavy ribs. The soft tissue anomalies included internal hydrocephalus, microphthalmia and kidney agenesis. es_ES
dc.description.sponsorship Financial support of the Indian Council of Agricultural Research, New Delhi under NATP-CGP Project is gratefully acknowledged.
dc.description.tableofcontents 171
dc.language Inglés es_ES
dc.publisher World Rabbit Science. ICTA. UPV es_ES
dc.relation.ispartof World Rabbit Science
dc.rights Reserva de todos los derechos es_ES
dc.subject Ochratoxin a es_ES
dc.subject Teratogenicity es_ES
dc.subject Rabbit es_ES
dc.title Teratogenic effects of ochratoxin a in rabbits es_ES
dc.type Artículo es_ES
dc.date.updated 2011-02-14T11:10:11Z
dc.identifier.doi 10.4995/wrs.2004.573
dc.rights.accessRights Abierto es_ES
dc.description.bibliographicCitation Wangikar, P.; Dwivedi, P.; Sinha, N. (2004). Teratogenic effects of ochratoxin a in rabbits. World Rabbit Science. 12(3). doi:10.4995/wrs.2004.573 es_ES
dc.description.accrualMethod SWORD es_ES
dc.relation.publisherversion https://doi.org/10.4995/wrs.2004.573
dc.description.upvformatpinicio 159
dc.description.volume 12
dc.description.issue 3
dc.identifier.eissn 1989-8886 es_ES
dc.contributor.funder Indian Council of Agricultural Research


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