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dc.contributor.author | POVEDA-REYES, SARA | es_ES |
dc.contributor.author | Mellera-Oglialoro, Leonardo Rubén | es_ES |
dc.contributor.author | Martínez-Haya, Rebeca | es_ES |
dc.contributor.author | Gamboa Martínez, Tatiana Carolina | es_ES |
dc.contributor.author | Gómez Ribelles, José Luís | es_ES |
dc.contributor.author | Ferrer, G.G. | es_ES |
dc.date.accessioned | 2018-03-04T05:16:38Z | |
dc.date.available | 2018-03-04T05:16:38Z | |
dc.date.issued | 2015 | es_ES |
dc.identifier.issn | 1438-7492 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/98770 | |
dc.description.abstract | [EN] Short poly-l-lactic acid (PLLA) microfibers have been produced in order to disperse them into the gelatin solution and enable injection in the tissue defect prior to gel formation. Two methods for fabrication of loose fibers with submicrometric dimensions are presented in this paper. One is based on manufacturing electrospun meshes and subsequent milling (PLLA-ES) and the other involves projection of a PLLA solution into a high turbulent non-solvent medium (PLLA-HT). Composites produced with PLLA-ES show a compression Young's modulus from 2.65kPa for the pure gelatin to 6.69kPa for the composite with 1.5% PLLA-ES fibers. The new injectable gelatin-fiber composites are not cytotoxic. | es_ES |
dc.description.sponsorship | The authors are grateful for the financial support received from the Spanish Ministry through the MAT2013-46467-C4-1-R project and the BES-2011-046144 grant. CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program. CIBER actions are financed by the "Instituto de Salud Carlos III'' with assistance from the European Regional Development Fund. The authors thank "Servicio de Microscopia Electronica'' of Universitat Politecnica de Valencia for their valuable help. The translation of this paper was funded by the Universitat Politecnica de Valencia, Spain. | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | John Wiley & Sons | es_ES |
dc.relation.ispartof | Macromolecular Materials and Engineering | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Enzymatic cross-linking | es_ES |
dc.subject | Injectable hydrogels | es_ES |
dc.subject | Microfiber-hydrogel composites | es_ES |
dc.subject | Short microfibers | es_ES |
dc.subject.classification | TERMODINAMICA APLICADA (UPV) | es_ES |
dc.subject.classification | MAQUINAS Y MOTORES TERMICOS | es_ES |
dc.title | Reinforcing an Injectable Gelatin Hydrogel with PLLA Microfibers: Two Routes for Short Fiber Production | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1002/mame.201500033 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//MAT2013-46467-C4-1-R/ES/ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVA/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//BES-2011-046144/ES/BES-2011-046144/ | es_ES |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada | es_ES |
dc.description.bibliographicCitation | Poveda-Reyes, S.; Mellera-Oglialoro, LR.; Martínez-Haya, R.; Gamboa Martínez, TC.; Gómez Ribelles, JL.; Ferrer, G. (2015). Reinforcing an Injectable Gelatin Hydrogel with PLLA Microfibers: Two Routes for Short Fiber Production. Macromolecular Materials and Engineering. 300(10):977-988. https://doi.org/10.1002/mame.201500033 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1002/mame.201500033 | es_ES |
dc.description.upvformatpinicio | 977 | es_ES |
dc.description.upvformatpfin | 988 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 300 | es_ES |
dc.description.issue | 10 | es_ES |
dc.relation.pasarela | S\293310 | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es_ES |
dc.description.references | Da Silva, M. A., Bode, F., Drake, A. F., Goldoni, S., Stevens, M. M., & Dreiss, C. A. (2014). Enzymatically Cross-Linked Gelatin/Chitosan Hydrogels: Tuning Gel Properties and Cellular Response. Macromolecular Bioscience, 14(6), 817-830. doi:10.1002/mabi.201300472 | es_ES |
dc.description.references | Jayakrishnan, A., & Jameela, S. R. (1996). Glutaraldehyde as a fixative in bioprostheses and drug delivery matrices. Biomaterials, 17(5), 471-484. doi:10.1016/0142-9612(96)82721-9 | es_ES |
dc.description.references | Lai, J.-Y. (2010). Biocompatibility of chemically cross-linked gelatin hydrogels for ophthalmic use. Journal of Materials Science: Materials in Medicine, 21(6), 1899-1911. doi:10.1007/s10856-010-4035-3 | es_ES |
dc.description.references | Yang, S.-H., Chen, P.-Q., Chen, Y.-F., & Lin, F.-H. (2005). An In-vitro Study on Regeneration of Human Nucleus Pulposus by Using Gelatin/Chondroitin-6-Sulfate/Hyaluronan Tri-copolymer Scaffold. Artificial Organs, 29(10), 806-814. doi:10.1111/j.1525-1594.2005.00133.x | es_ES |
dc.description.references | Hoch, E., Schuh, C., Hirth, T., Tovar, G. E. M., & Borchers, K. (2012). Stiff gelatin hydrogels can be photo-chemically synthesized from low viscous gelatin solutions using molecularly functionalized gelatin with a high degree of methacrylation. Journal of Materials Science: Materials in Medicine, 23(11), 2607-2617. doi:10.1007/s10856-012-4731-2 | es_ES |
dc.description.references | Van Den Bulcke, A. I., Bogdanov, B., De Rooze, N., Schacht, E. H., Cornelissen, M., & Berghmans, H. (2000). Structural and Rheological Properties of Methacrylamide Modified Gelatin Hydrogels. Biomacromolecules, 1(1), 31-38. doi:10.1021/bm990017d | es_ES |
dc.description.references | Falabella, C. A., & Chen, W. (2009). Cross-Linked Hyaluronic Acid Films to Reduce Intra-Abdominal Postsurgical Adhesions in an Experimental Model. Digestive Surgery, 26(6), 476-481. doi:10.1159/000253872 | es_ES |
dc.description.references | Cheng, Y., Lu, J., Liu, S., Zhao, P., Lu, G., & Chen, J. (2014). The preparation, characterization and evaluation of regenerated cellulose/collagen composite hydrogel films. Carbohydrate Polymers, 107, 57-64. doi:10.1016/j.carbpol.2014.02.034 | es_ES |
dc.description.references | Bao, T.-Q., Franco, R. A., & Lee, B.-T. (2012). Preparation and characterization of a novel 3D scaffold from poly(ɛ-caprolactone)/biphasic calcium phosphate hybrid composite microspheres adhesion. Biochemical Engineering Journal, 64, 76-83. doi:10.1016/j.bej.2012.02.005 | es_ES |
dc.description.references | Lin, L.-C., Chang, S. J., Lin, C. Y., Lin, Y. T., Chuang, C. W., Yao, C.-H., & Kuo, S. M. (2011). Repair of Chondral Defects With Allogenous Chondrocyte-Seeded Hyaluronan/Collagen II Microspheres in a Rabbit Model. Artificial Organs, 36(4), E102-E109. doi:10.1111/j.1525-1594.2011.01370.x | es_ES |
dc.description.references | Chan, B. P., & Leong, K. W. (2008). Scaffolding in tissue engineering: general approaches and tissue-specific considerations. European Spine Journal, 17(S4), 467-479. doi:10.1007/s00586-008-0745-3 | es_ES |
dc.description.references | Li, Y., Rodrigues, J., & Tomás, H. (2012). Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications. Chem. Soc. Rev., 41(6), 2193-2221. doi:10.1039/c1cs15203c | es_ES |
dc.description.references | Wang, L.-S., Chung, J. E., Pui-Yik Chan, P., & Kurisawa, M. (2010). Injectable biodegradable hydrogels with tunable mechanical properties for the stimulation of neurogenesic differentiation of human mesenchymal stem cells in 3D culture. Biomaterials, 31(6), 1148-1157. doi:10.1016/j.biomaterials.2009.10.042 | es_ES |
dc.description.references | JIN, R., HIEMSTRA, C., ZHONG, Z., & FEIJEN, J. (2007). Enzyme-mediated fast in situ formation of hydrogels from dextran–tyramine conjugates. Biomaterials, 28(18), 2791-2800. doi:10.1016/j.biomaterials.2007.02.032 | es_ES |
dc.description.references | Davis, N. E., Ding, S., Forster, R. E., Pinkas, D. M., & Barron, A. E. (2010). Modular enzymatically crosslinked protein polymer hydrogels for in situ gelation. Biomaterials, 31(28), 7288-7297. doi:10.1016/j.biomaterials.2010.06.003 | es_ES |
dc.description.references | Moreira Teixeira, L. S., Feijen, J., van Blitterswijk, C. A., Dijkstra, P. J., & Karperien, M. (2012). Enzyme-catalyzed crosslinkable hydrogels: Emerging strategies for tissue engineering. Biomaterials, 33(5), 1281-1290. doi:10.1016/j.biomaterials.2011.10.067 | es_ES |
dc.description.references | Yung, C. W., Wu, L. Q., Tullman, J. A., Payne, G. F., Bentley, W. E., & Barbari, T. A. (2007). Transglutaminase crosslinked gelatin as a tissue engineering scaffold. Journal of Biomedical Materials Research Part A, 83A(4), 1039-1046. doi:10.1002/jbm.a.31431 | es_ES |
dc.description.references | Sakai, S., Hirose, K., Taguchi, K., Ogushi, Y., & Kawakami, K. (2009). An injectable, in situ enzymatically gellable, gelatin derivative for drug delivery and tissue engineering. Biomaterials, 30(20), 3371-3377. doi:10.1016/j.biomaterials.2009.03.030 | es_ES |
dc.description.references | Wang, L.-S., Du, C., Toh, W. S., Wan, A. C. A., Gao, S. J., & Kurisawa, M. (2014). Modulation of chondrocyte functions and stiffness-dependent cartilage repair using an injectable enzymatically crosslinked hydrogel with tunable mechanical properties. Biomaterials, 35(7), 2207-2217. doi:10.1016/j.biomaterials.2013.11.070 | es_ES |
dc.description.references | Wang, L.-S., Du, C., Chung, J. E., & Kurisawa, M. (2012). Enzymatically cross-linked gelatin-phenol hydrogels with a broader stiffness range for osteogenic differentiation of human mesenchymal stem cells. Acta Biomaterialia, 8(5), 1826-1837. doi:10.1016/j.actbio.2012.02.002 | es_ES |
dc.description.references | Lee, F., Chung, J. E., & Kurisawa, M. (2009). An injectable hyaluronic acid–tyramine hydrogel system for protein delivery. Journal of Controlled Release, 134(3), 186-193. doi:10.1016/j.jconrel.2008.11.028 | es_ES |
dc.description.references | Darr, A., & Calabro, A. (2008). Synthesis and characterization of tyramine-based hyaluronan hydrogels. Journal of Materials Science: Materials in Medicine, 20(1), 33-44. doi:10.1007/s10856-008-3540-0 | es_ES |
dc.description.references | Toh, W. S., Lim, T. C., Kurisawa, M., & Spector, M. (2012). Modulation of mesenchymal stem cell chondrogenesis in a tunable hyaluronic acid hydrogel microenvironment. Biomaterials, 33(15), 3835-3845. doi:10.1016/j.biomaterials.2012.01.065 | es_ES |
dc.description.references | SAKAI, S., & KAWAKAMI, K. (2007). Synthesis and characterization of both ionically and enzymatically cross-linkable alginate. Acta Biomaterialia, 3(4), 495-501. doi:10.1016/j.actbio.2006.12.002 | es_ES |
dc.description.references | Sakai, S., Moriyama, K., Taguchi, K., & Kawakami, K. (2010). Hematin is an Alternative Catalyst to Horseradish Peroxidase for In Situ Hydrogelation of Polymers with Phenolic Hydroxyl Groups In Vivo. Biomacromolecules, 11(8), 2179-2183. doi:10.1021/bm100623k | es_ES |
dc.description.references | Chen, T., Embree, H. D., Brown, E. M., Taylor, M. M., & Payne, G. F. (2003). Enzyme-catalyzed gel formation of gelatin and chitosan: potential for in situ applications. Biomaterials, 24(17), 2831-2841. doi:10.1016/s0142-9612(03)00096-6 | es_ES |
dc.description.references | Wang, L.-S., Boulaire, J., Chan, P. P. Y., Chung, J. E., & Kurisawa, M. (2010). The role of stiffness of gelatin–hydroxyphenylpropionic acid hydrogels formed by enzyme-mediated crosslinking on the differentiation of human mesenchymal stem cell. Biomaterials, 31(33), 8608-8616. doi:10.1016/j.biomaterials.2010.07.075 | es_ES |
dc.description.references | Gu, W. Y., Yao, H., Huang, C. Y., & Cheung, H. S. (2003). New insight into deformation-dependent hydraulic permeability of gels and cartilage, and dynamic behavior of agarose gels in confined compression. Journal of Biomechanics, 36(4), 593-598. doi:10.1016/s0021-9290(02)00437-2 | es_ES |
dc.description.references | Spagnol, C., Rodrigues, F. H. A., Neto, A. G. V. C., Pereira, A. G. B., Fajardo, A. R., Radovanovic, E., … Muniz, E. C. (2012). Nanocomposites based on poly(acrylamide-co-acrylate) and cellulose nanowhiskers. European Polymer Journal, 48(3), 454-463. doi:10.1016/j.eurpolymj.2011.12.005 | es_ES |
dc.description.references | Liu, X., Huang, C., Feng, Y., Liang, J., Fan, Y., Gu, Z., & Zhang, X. (2010). Reinforcement of a Porous Collagen Scaffold with Surface-Activated PLA Fibers. Journal of Biomaterials Science, Polymer Edition, 21(6-7), 963-977. doi:10.1163/156856209x461034 | es_ES |
dc.description.references | Wayne, J. S., McDowell, C. L., Shields, K. J., & Tuan, R. S. (2005). In Vivo Response of Polylactic Acid–Alginate Scaffolds and Bone Marrow-Derived Cells for Cartilage Tissue Engineering. Tissue Engineering, 11(5-6), 953-963. doi:10.1089/ten.2005.11.953 | es_ES |
dc.description.references | Sherwood, J. K., Riley, S. L., Palazzolo, R., Brown, S. C., Monkhouse, D. C., Coates, M., … Ratcliffe, A. (2002). A three-dimensional osteochondral composite scaffold for articular cartilage repair. Biomaterials, 23(24), 4739-4751. doi:10.1016/s0142-9612(02)00223-5 | es_ES |
dc.description.references | Regev, O., Reddy, C. S., Nseir, N., & Zussman, E. (2012). Hydrogel Reinforced by Short Albumin Fibers: Mechanical Characterization and Assessment of Biocompatibility. Macromolecular Materials and Engineering, 298(3), 283-291. doi:10.1002/mame.201200012 | es_ES |
dc.description.references | Moutos, F. T., Freed, L. E., & Guilak, F. (2007). A biomimetic three-dimensional woven composite scaffold for functional tissue engineering of cartilage. Nature Materials, 6(2), 162-167. doi:10.1038/nmat1822 | es_ES |
dc.description.references | Maranchi, J. P., Trexler, M. M., Guo, Q., & Elisseeff, J. H. (2014). Fibre-reinforced hydrogels with high optical transparency. International Materials Reviews, 59(5), 264-296. doi:10.1179/1743280414y.0000000032 | es_ES |
dc.description.references | Sutti, A., Lin, T., & Wang, X. (2011). Shear-Enhanced Solution Precipitation: A Simple Process to Produce Short Polymeric Nanofibers. Journal of Nanoscience and Nanotechnology, 11(10), 8947-8952. doi:10.1166/jnn.2011.3489 | es_ES |
dc.description.references | De Moraes, M. A., Paternotte, E., Mantovani, D., & Beppu, M. M. (2012). Mechanical and Biological Performances of New Scaffolds Made of Collagen Hydrogels and Fibroin Microfibers for Vascular Tissue Engineering. Macromolecular Bioscience, 12(9), 1253-1264. doi:10.1002/mabi.201200060 | es_ES |
dc.description.references | Chen, W., Yu, H., Liu, Y., Chen, P., Zhang, M., & Hai, Y. (2011). Individualization of cellulose nanofibers from wood using high-intensity ultrasonication combined with chemical pretreatments. Carbohydrate Polymers, 83(4), 1804-1811. doi:10.1016/j.carbpol.2010.10.040 | es_ES |
dc.description.references | Greenfeld, I., & Zussman, E. (2013). Polymer entanglement loss in extensional flow: Evidence from electrospun short nanofibers. Journal of Polymer Science Part B: Polymer Physics, 51(18), 1377-1391. doi:10.1002/polb.23345 | es_ES |
dc.description.references | Coburn, J. M., Gibson, M., Monagle, S., Patterson, Z., & Elisseeff, J. H. (2012). Bioinspired nanofibers support chondrogenesis for articular cartilage repair. Proceedings of the National Academy of Sciences, 109(25), 10012-10017. doi:10.1073/pnas.1121605109 | es_ES |
dc.description.references | Santana, B. P., dos Reis Paganotto, G. F., Nedel, F., Piva, E., de Carvalho, R. V., Nör, J. E., … Villarreal Carreño, N. L. (2012). Nano-/microfiber scaffold for tissue engineering: Physical and biological properties. Journal of Biomedical Materials Research Part A, 100A(11), 3051-3058. doi:10.1002/jbm.a.34242 | es_ES |
dc.description.references | Hsieh, A., Zahir, T., Lapitsky, Y., Amsden, B., Wan, W., & Shoichet, M. S. (2010). Hydrogel/electrospun fiber composites influence neural stem/progenitor cell fate. Soft Matter, 6(10), 2227. doi:10.1039/b924349f | es_ES |
dc.description.references | Yan, X., & Sun, W. (2010). Synthesis and metal ion adsorption studies of chelating resins derived from macroporous glycidyl methacrylate-divinylbenzene copolymer beads anchored schiff bases. Journal of Applied Polymer Science, 117(2), 953-959. doi:10.1002/app.31482 | es_ES |
dc.description.references | Kai, D., Prabhakaran, M. P., Stahl, B., Eblenkamp, M., Wintermantel, E., & Ramakrishna, S. (2012). Mechanical properties andin vitrobehavior of nanofiber–hydrogel composites for tissue engineering applications. Nanotechnology, 23(9), 095705. doi:10.1088/0957-4484/23/9/095705 | es_ES |
dc.description.references | Montaño-Leyva, B., Ghizzi D. da Silva, G., Gastaldi, E., Torres-Chávez, P., Gontard, N., & Angellier-Coussy, H. (2013). Biocomposites from wheat proteins and fibers: Structure/mechanical properties relationships. Industrial Crops and Products, 43, 545-555. doi:10.1016/j.indcrop.2012.07.065 | es_ES |
dc.description.references | Coburn, J., Gibson, M., Bandalini, P. A., Laird, C., Mao, H.-Q., Moroni, L., … Elisseeff, J. (2011). Biomimetics of the extracellular matrix: an integrated three-dimensional fiber-hydrogel composite for cartilage tissue engineering. Smart Structures and Systems, 7(3), 213-222. doi:10.12989/sss.2011.7.3.213 | es_ES |
dc.description.references | Tonsomboon, K., & Oyen, M. L. (2013). Composite electrospun gelatin fiber-alginate gel scaffolds for mechanically robust tissue engineered cornea. Journal of the Mechanical Behavior of Biomedical Materials, 21, 185-194. doi:10.1016/j.jmbbm.2013.03.001 | es_ES |
dc.description.references | Tucker III, C. L., & Liang, E. (1999). Stiffness predictions for unidirectional short-fiber composites: Review and evaluation. Composites Science and Technology, 59(5), 655-671. doi:10.1016/s0266-3538(98)00120-1 | es_ES |
dc.description.references | Yuan, T., Li, K., Guo, L., Fan, H., & Zhang, X. (2011). Modulation of immunological properties of allogeneic mesenchymal stem cells by collagen scaffolds in cartilage tissue engineering. Journal of Biomedical Materials Research Part A, 98A(3), 332-341. doi:10.1002/jbm.a.33121 | es_ES |
dc.description.references | Oh, S.-A., Lee, H.-Y., Lee, J. H., Kim, T.-H., Jang, J.-H., Kim, H.-W., & Wall, I. (2012). Collagen Three-Dimensional Hydrogel Matrix Carrying Basic Fibroblast Growth Factor for the Cultivation of Mesenchymal Stem Cells and Osteogenic Differentiation. Tissue Engineering Part A, 18(9-10), 1087-1100. doi:10.1089/ten.tea.2011.0360 | es_ES |
dc.description.references | Zhang, L., Yuan, T., Guo, L., & Zhang, X. (2012). Anin vitrostudy of collagen hydrogel to induce the chondrogenic differentiation of mesenchymal stem cells. Journal of Biomedical Materials Research Part A, 100A(10), 2717-2725. doi:10.1002/jbm.a.34194 | es_ES |
dc.description.references | Brigham, M. D., Bick, A., Lo, E., Bendali, A., Burdick, J. A., & Khademhosseini, A. (2009). Mechanically Robust and Bioadhesive Collagen and Photocrosslinkable Hyaluronic Acid Semi-Interpenetrating Networks. Tissue Engineering Part A, 15(7), 1645-1653. doi:10.1089/ten.tea.2008.0441 | es_ES |
dc.description.references | Mehra, T. D., Ghosh, K., Shu, X. Z., Prestwich, G. D., & Clark, R. A. F. (2006). Molecular Stenting with a Crosslinked Hyaluronan Derivative Inhibits Collagen Gel Contraction. Journal of Investigative Dermatology, 126(10), 2202-2209. doi:10.1038/sj.jid.5700380 | es_ES |
dc.description.references | Yamato, M., Adachi, E., Yamamoto, K., & Hayashi, T. (1995). Condensation of Collagen Fibrils to the Direct Vicinity of Fibroblasts as a Cause of Gel Contraction1. The Journal of Biochemistry, 117(5), 940-946. doi:10.1093/oxfordjournals.jbchem.a124824 | es_ES |
dc.description.references | Fu, Y., Xu, K., Zheng, X., Giacomin, A. J., Mix, A. W., & Kao, W. J. (2012). 3D cell entrapment in crosslinked thiolated gelatin-poly(ethylene glycol) diacrylate hydrogels. Biomaterials, 33(1), 48-58. doi:10.1016/j.biomaterials.2011.09.031 | es_ES |
dc.description.references | Baker, B. M., & Chen, C. S. (2012). Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues. Journal of Cell Science, 125(13), 3015-3024. doi:10.1242/jcs.079509 | es_ES |
dc.description.references | Steward, A., Wagner, D., & Kelly, D. (2013). The pericellular environment regulates cytoskeletal development and the differentiation of mesenchymal stem cells and determines their response to hydrostatic pressure. European Cells and Materials, 25, 167-178. doi:10.22203/ecm.v025a12 | es_ES |