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Acetylcholinesterase-capped Mesoporous Silica Nanoparticles Controlled by the Presence of Inhibitors

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Acetylcholinesterase-capped Mesoporous Silica Nanoparticles Controlled by the Presence of Inhibitors

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dc.contributor.author Pascual, Lluís es_ES
dc.contributor.author El Sayed Shehata Nasr, Sameh es_ES
dc.contributor.author Marcos Martínez, María Dolores es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.date.accessioned 2018-03-23T13:05:49Z
dc.date.available 2018-03-23T13:05:49Z
dc.date.issued 2017 es_ES
dc.identifier.issn 1861-4728 es_ES
dc.identifier.uri http://hdl.handle.net/10251/99648
dc.description.abstract [EN] Two different acetylcholinesterase (AChE)-capped mesoporous silica nanoparticles (MSNs), S1-AChE and S2-AChE, were prepared and characterized. MSNs were loaded with rhodamine B and the external surface was functionalized with either pyridostigmine derivative P1 (to yield solid S1) or neostigmine derivative P2 (to obtain S2). The final capped materials were obtained by coordinating grafted P1 or P2 with AChE ' s active sites (to give S1-AChE and S2-AChE, respectively). Both materials were able to release rho-damine B in the presence of diisopropylfluorophosphate (DFP) or neostigmine in a concentration-dependent manner via the competitive displacement of AChE through DFP and neostigmine coordination with the AChE ' s active sites. The responses of S1-AChE and S2-AChE were also tested with other enzyme inhibitors and substrates. These studies suggest that S1-AChE nanoparticles can be used for the selective detection of nerve agent simulant DFP and paraoxon. es_ES
dc.description.sponsorship Financial support from the Spanish Government and FEDER funds (Project MAT2015‐64139‐C4‐1‐R, AGL2015‐70235‐C2‐2‐R) and the Generalitat Valencia (Project PROMETEOII/2014/047) is gratefully acknowledged. Ll. P. is grateful to the Universitat Politécnica de Valencia for his grant.
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation.ispartof Chemistry - An Asian Journal es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Acetylcholinesterase es_ES
dc.subject Enzyme inhibitors es_ES
dc.subject Enzyme-capped nanoparticles es_ES
dc.subject Neostigmine es_ES
dc.subject Nerve agent simulants es_ES
dc.subject.classification INGENIERIA DE LA CONSTRUCCION es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Acetylcholinesterase-capped Mesoporous Silica Nanoparticles Controlled by the Presence of Inhibitors es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/asia.201700031 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEOII%2F2014%2F047/ES/Nuevas aproximaciones para el diseño de materiales de liberación controlada y la detección de compuestos peligrosos/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2015-64139-C4-1-R/ES/NANOMATERIALES INTELIGENTES, SONDAS Y DISPOSITIVOS PARA EL DESARROLLO INTEGRADO DE NUEVAS HERRAMIENTAS APLICADAS AL CAMPO BIOMEDICO/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//AGL2015-70235-C2-2-R/ES/DESARROLLO DE SISTEMAS HIBRIDOS CON OPTIMIZACION DEL ANCLADO DE BIOMOLECULAS Y DISEÑADOS CON PROPIEDADES DE ENCAPSULACION Y LIBERACION CONTROLADA MEJORADAS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Pascual, L.; El Sayed Shehata Nasr, S.; Marcos Martínez, MD.; Martínez-Máñez, R.; Sancenón Galarza, F. (2017). Acetylcholinesterase-capped Mesoporous Silica Nanoparticles Controlled by the Presence of Inhibitors. Chemistry - An Asian Journal. 12(7):775-784. https://doi.org/10.1002/asia.201700031 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1002/asia.201700031 es_ES
dc.description.upvformatpinicio 775 es_ES
dc.description.upvformatpfin 784 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 12 es_ES
dc.description.issue 7 es_ES
dc.relation.pasarela S\336319 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Economía, Industria y Competitividad es_ES
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