Lucena Sánchez, Elena(Universitat Politècnica de València, 2024-06-21)
[ES] La presente tesis doctoral titulada "New advanced anti-tumor therapies based on hybrid mesoporous nanodevices" se centra en el diseño, síntesis, caracterización y evaluación de nuevos nanodispositivos híbridos ...
[EN] One appealing concept in the field of hybrid materials is related to the design of gated materials. These materials are prepared in such a way that the release of chemical or biochemical species from voids of porous ...
Lérida Viso, Araceli(Universitat Politècnica de València, 2023-07-06)
[ES] La presente tesis doctoral titulada "La terapia senolítica como nuevo enfoque terapéutico para la prevención de la cardiotoxicidad inducida por la doxorrubicina" se centra en explorar la eliminación de células senescentes ...
[EN] Many anticancer agents used in clinics induce premature senescence in healthy tissues generating accelerated aging processes and adverse side-effects in patients. Cardiotoxicity is a well-known limiting factor of ...
Vivo Llorca, Gema(Universitat Politècnica de València, 2017-10-25)
The aim of this project is to optimize a novel nanodispositive based on silica mesoporous nanoparticles (MSNs) for genome editing in human cell lines, using CRISPR/Cas9 technology. It focuses on the synthesis and ...
[EN] In vivo detection of cellular senescence is accomplished by using mesoporous silica nanoparticles loaded with the NIR-FDA approved Nile blue (NB) dye and capped with a galactohexasaccharide (S3). NB emission at 672 ...
[EN] Acute lung injury (ALI) is a severe pulmonary disorder responsible for high percentage of mortality and morbidity in intensive care unit patients. Current treatments are ineffective, so the development of efficient ...
[EN] Acute lung injury (ALI) is a critical inflammatory syndrome, characterized by increased diffuse inflammation and severe lung damage, which represents a clinical concern due to the high morbidity and mortality in ...