Dopamine-mediated neurotransmission plays an important role in relevant psychiatric and neurological disorders. Nowadays, there is an enormous interest in the development of new dopamine receptors (DR) acting drugs as ...
Two series of halogenated 1-benzyl-7-chloro-6-hydroxy-tetrahydroisoquinolines were prepared to explore the influence of each series on the affinity for dopamine receptors. All the compounds displayed a high affinity for ...
Parravicini, Oscar; Bogado, M. Lucrecia; Rojas, Sebastián; Angelina, Emilio L.; Andujar, Sebastián A.; Gutierrez, Lucas J.; Cabedo Escrig, Nuria; López-Gresa, María Pilar; Sanz, M. Jesús; Cortes, Diego; Enriz, Ricardo D.(Springer-Verlag, 2017-09)
[EN] A series of tetrahydroisoquinolines functionalized with carbamates is reported here as highly selective ligands on the dopamine D2 receptor. These compounds were selected by means of a molecular modeling study. The ...