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Browsing by Author "Bermejo, Marival"

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Browsing by Author "Bermejo, Marival"

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    A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability 
    Rodríguez Berna, Guillermo; Mangas Sanjuan, Victor; Gonzalez Alvarez, Marta; Gonzalez Álvarez, Isabel; Garcia Gimenez, Jose Luis; Díaz Cabañas, Mª José; Bermejo, Marival; Corma Canós, Avelino (Elsevier, 2014-08-18)
    Oral administration of camptothecin (Cm) derivatives and other antitumoral agents is being actively developed in order to improve the quality of life of patients with cancer. Though several lipophilic derivatives of CPT ...
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    Candesartan Cilexetil In Vitro-In Vivo Correlation: Predictive Dissolution as a Development Tool 
    Figueroa-Campos, Andrés; Sánchez-Dengra, Bárbara; Merino, Virginia; Dahan, Arik; Gonzalez-Alvarez, Isabel; García-Arieta, Alfredo; Gonzalez-Alvarez, Marta; Bermejo, Marival (MDPI AG, 2020-07)
    [EN] The main objective of this investigation was to develop an in vitro-in vivo correlation (IVIVC) for immediate release candesartan cilexetil formulations by designing an in vitro dissolution test to be used as development ...
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    Covalently crosslinked organophosphorous derivatives-chitosan hydrogel as a drug delivery system for oral administration of camptothecin 
    Martínez-Martínez, M.; Rodríguez Berna, Guillermo; Bermejo, Marival; Gonzalez-Alvarez, Isabel; Gonzalez -Alvarez, Marta; Merino, Virginia (Elsevier, 2019-03)
    [EN] Hydrogels are widely studied as drug delivery system. In this work we propose the employment of tetrakis (hydroxymethyl)phosphonium chloride as crosslinking agent to obtain covalent hydrogels based on chitosan. These ...
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    Ionic Hydrogel Based on Chitosan Cross-Linked with 6-Phosphogluconic Trisodium Salt as a Drug Delivery System 
    Martínez Martínez, Mayte; Rodríguez Berna, Guillermo; Gonzalez-Alvarez, Isabel; Hernández, María Jesús; Corma Canós, Avelino; Bermejo, Marival; Merino Sanjuán, Virginia; Gonzalez -Alvarez, Marta (American Chemical Society, 2018-04)
    [EN] In this work, 6-phosphogluconic trisodium salt (6-PG(-)Na(+)) is introduced as a new aqueous and nontoxic cross-linking agent to obtain ionic hydrogels. Here, it is shown the formation of hydrogels based on chitosan ...
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    New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy 
    Hernández Teruel, Adrián; Gonzalez-Alvarez, Isabel; Bermejo, Marival; Merino Sanjuán, Virginia; Marcos Martínez, María Dolores; Sancenón Galarza, Félix; Gonzalez-Alvarez, Marta; Martínez-Máñez, Ramón (MDPI AG, 2020-09)
    [EN] Colonic Drug Delivery Systems (CDDS) are especially advantageous for local treatment of inflammatory bowel diseases (IBD). Site-targeted drug release allows to obtain a high drug concentration in injured tissues and ...
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    pH-Dependent Molecular Gate Mesoporous Microparticles for Biological Control of Giardia intestinalis 
    Gonzalez-Alvarez, Isabel; Vivancos, Verónica; Coll Merino, Mª Carmen; Sánchez-Dengra, B.; Aznar, Elena; Ruiz Picazo, Alejandro; Bermejo, Marival; Sancenón Galarza, Félix; Dea-Ayuela, M. Auxiliadora; Gonzalez -Alvarez, Marta; Martínez-Máñez, Ramón (MDPI AG, 2021-01)
    [EN] Giardiasis is a parasitism produced by the protozoa Giardia intestinalis that lives as trophozoite in the small intestine (mainly in the duodenum) attached to the intestinal villus by means of billed discs. The first ...
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    Semisynthesis, Cytotoxic Activity, and Oral Availability of New Lipophilic 9-Substituted Camptothecim Derivatives 
    Rodríguez Berna, Guillermo; Díaz Cabañas, Mª José; Mangas Sanjuan, Víctor; Gonzalez Alvarez, Marta; Gonzalez Álvarez, Isabel; Abasolo, Ibane; Simo Schwartz, Jr.; Bermejo, Marival; Corma Canós, Avelino (American Chemical Society, 2013-05-28)
    Despite that 9-substituted camptothecins are promising candidates in cancer therapy, the limited accessibility to this position has reduced the studies of these derivatives to a few standard modifications. We report herein ...