Martínez-Rodríguez, David; González Parra, Gilberto; Villanueva Micó, Rafael Jacinto(MDPI AG, 2021-04-01)
[EN] The administration of vaccines against the coronavirus disease 2019 (COVID-19) started in early December of 2020. Currently, there are only a few approved vaccines, each with different efficacies and mechanisms of ...
Salinet, Joao; Molero-Alabau, Rubén; Schlindwein, Fernando S.; Karel, Joël; Rodrigo, Miguel; Rojo-Álvarez, José Luis; Berenfeld, Omer; Climent, Andreu M.; Zenger, Brian; Vanheusden, Frederique; Siles Paredes, Jimena Gabriela; MacLeod, Rob; Atienza, Felipe; Guillem Sánchez, María Salud; Cluitmans, Matthijs; Bonizzi, Pietro(Frontiers Media SA, 2021-04-30)
[EN] Electrocardiographic imaging (ECGI) is a technique to reconstruct non-invasively the electrical activity on the heart surface from body-surface potential recordings and geometric information of the torso and the heart. ...
González Parra, Gilberto; Martínez-Rodríguez, David; Villanueva Micó, Rafael Jacinto(MDPI AG, 2021-03-27)
[EN] Several SARS-CoV-2 variants have emerged around the world, and the appearance of other variants depends on many factors. These new variants might have different characteristics that can affect the transmissibility and ...
[EN] Genetic variants in Ankyrin Repeat Domain 11 (ANKRD11) and deletions in 16q24.3 are known to cause KBG syndrome, a rare syndrome associated with craniofacial, intellectual, and neurobehavioral anomalies. We report 25 ...
Rodríguez-Fernández, Karine; Reynaldo-Fernández, G.; Reyes-González, Stephanie; de las Barreras, Camila; Rodríguez-Vera, Leyanis; Vlaar, Cornelis; Monbaliu, Jean-Christophe M.; Stelzer, Torsten; Duconge, Jorge; Mangas-Sanjuan, Victor(Elsevier, 2024-01)
[EN] Warfarin, an oral anticoagulant, has been used for decades to prevent thromboembolic events. The complex interplay between CYP2C9 and VKORC1 genotypes on warfarin PK and PD properties is not fully understood in special ...
Peña Mendizabal, Edurne(Universitat Politècnica de València, 2022-05-09)
[EN] About 10 % of all adverse drug reactions are due to allergies, with ß-lactam antibiotics causing the majority of the episodes. Although the actual incidence remains unknown, individuals suspected of being allergic to ...
Peña-Mendizábal, Edurne; Hua, Bruce K.; Ibáñez-Echevarría, Ethel; Hernández-Fernández de Rojas, Dolores; Maquieira Catala, Angel; Schreiber, Stuart L.; Morais, Sergi(The Royal Society of Chemistry, 2022-05-17)
[EN] We present the first synthesis of beta-lactam-derived haptens, leveraging the principles of diversity-oriented synthesis to discover compounds for drug allergy in vitro testing. We designed, synthesised, and performed ...
[EN] Queuosine (Q) is a conserved hypermodification of the wobble base of tRNA containing GUN anticodons but the physiological consequences of Q deficiency are poorly understood in bacteria. This work combines transcriptomic, ...
Cluitmans, Matthijs; Brooks, D.; MacLeod, Rob S.; Dossel, Olaf; Guillem Sánchez, María Salud; van Dam, P.; Svehlikova, Jana; He, Bin; Sapp, John; Wang, Liwei; Bear, Laura(Frontiers Media SA, 2018-09-20)
[EN] Electrocardiographic imaging (ECGI) reconstructs the electrical activity of the heart from a dense array of body-surface electrocardiograms and a patient-specific heart-torso geometry. Depending on how it is formulated, ...
Beer, Gerald; Segura, Manuel(Universitat Politècnica de València, 2009-04-01)
[EN] Given a continuous nonnegative functional λ that makes sense defined on an arbitrary metric space (X, d), one may consider those spaces in which each sequence (xn) for which lim n→∞λ(xn) = 0 clusters. The compact ...
Adler, B. Thomas; Alfaro, Luca de; Mola Velasco, Santiago Moisés; Rosso, Paolo; West, Andrew G(Springer Verlag (Germany), 2011)
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