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Listar por palabra clave "Drug resistance"

Mostrando ítems 1-4 de 4

Development of a 3D in Vitro Disease Model for Multiple Myeloma

Clara Trujillo, Sandra (Universitat Politècnica de València, 2022-09-06)

[ES] La ingeniería tisular ha evolucionado hacia el modelado de la fisiología humana in vitro. El microambiente de la médula ósea (BM) es también hogar de procesos malignos. El mieloma múltiple (MM) es una neoplasia ...
Functional and evolutionary genomics of antibiotic resistance in tuberculosis: from biology to global DR-TB control

Moreno Molina, Miguel Ángel (Universitat Politècnica de València, 2023-11-06)

[ES] La resistencia a los antibióticos en la tuberculosis es un grave problema de salud mundial y un obstáculo creciente para el control de la enfermedad. En esta tesis utilizamos la genómica como herramienta para estudiar ...
Live-cell assays reveal selectivity and sensitivity of the multidrug response in budding yeast

Vanacloig-Pedrós, Mª Elena; Lozano-Pérez, Carlos; Alarcon, B.; Pascual-Ahuir Giner, María Desamparados; Proft, Markus Hans (American Society for Biochemistry and Molecular Biology, 2019-08-30)

[EN] Pleiotropic drug resistance arises by the enhanced extrusion of bioactive molecules and is present in a wide range of organisms, ranging from fungi to human cells. A key feature of this adaptation is the sensitive ...
Novel microgel culture system as semi-solid three-dimensional in vitro model for the study of multiple myeloma proliferation and drug resistance

Clara-Trujillo, Sandra; Tolosa, Laia; Cordón, Lourdes; Sempere, Amparo; Gallego Ferrer, Gloria; Gómez Ribelles, José Luís (Elsevier, 2022-04)

[EN] Multiple myeloma (MM) is a hematological malignancy in which the patient's drug resistance is one of the main clinical problems. As 2D cultures do not recapitulate the cellular microenvironment, which has a key role ...

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