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Browsing by Subject "Drug delivery"

Now showing items 1-20 of 35

Amino modified metal-organic frameworks as pH-responsive nanoplatforms for safe delivery of camptothecin

Cabrera-García, Alejandro; Checa-Chavarria, Elisa; Rivero-Buceta, Eva María; MORENO MANZANO, VICTORIA; FERNANDEZ JOVER, EDUARDO; BOTELLA ASUNCION, PABLO (Elsevier, 2019-04-01)

[EN] MIL-100(Fe) and MIL-101(Fe) metal-organic frameworks (MOFs) are excellent vehicles for drug delivery systems (DDSs) due to their high biocompatibility and stability in physiological fluids, as well as their pore ...
Assessment of drug entrapment within liposomes using photophysical probes

Oliverio, Filomena; Nuin Plá, Neus Edurne; Andreu Ros, María Inmaculada; Ragno, Gaetano; Miranda Alonso, Miguel Ángel (Elsevier, 2014-10)

The photophysical and photochemical behavior of (R)-cinacalcet (CIN) and (S)-naproxen (NPX) entrapped within liposomes has been studied. For this purpose, liposome encapsulated drugs have been prepared through thin layer ...
Azobenzene polyesters used as gate-like scaffolds in nanoscopic hybrid systems

Bernardos Bau, Andrea; Mondragón Martínez, Laura; Javakhishvili, Irakli; Mas Font, Nuria; De la Torre Paredes, Cristina; Martínez Mañez, Ramón; Sancenón Galarza, Félix; Barat Baviera, José Manuel; Hvilsted, Soren; Orzaez, Mar; Pérez Payá, Enrique; Amorós, Pedro (Wiley-VCH Verlag, 2012-10-08)

The synthesis and characterisation of new capped silica mesoporous nanoparticles for on-command delivery applications is reported. Functional capped hybrid systems consist of MCM-41 nanoparticles functionalised on the ...
Broadening the antibacterial spectrum of histidine kinase autophosphorylation inhibitors via the use of epsilon-poly-L-lysine capped mesoporous silica-based nanoparticles

Velikova, Nadya; Mas Font, Nuria; MIguel-Romero, Laura; Polo, Lorena; Stolte, Ellen; Zaccaria, Edoardo; Cao, Rui; Taverne, Nico; Murguía, Jose R.; Martínez-Máñez, Ramón; Marina, Alberto; Wells, Jerry (Elsevier, 2017-02)

[EN] Two-component systems (TCS) regulate diverse processes such as virulence, stress responses, metabolism and antibiotic resistance in bacteria but are absent in humans, making them promising targets for novel antibacterials. ...
Covalently crosslinked organophosphorous derivatives-chitosan hydrogel as a drug delivery system for oral administration of camptothecin

Martínez-Martínez, M.; Rodríguez Berna, Guillermo; Bermejo, Marival; Gonzalez-Alvarez, Isabel; Gonzalez -Alvarez, Marta; Merino, Virginia (Elsevier, 2019-03)

[EN] Hydrogels are widely studied as drug delivery system. In this work we propose the employment of tetrakis (hydroxymethyl)phosphonium chloride as crosslinking agent to obtain covalent hydrogels based on chitosan. These ...
Desarrollo de andamiajes con porosidad estratificada basados en poliésteres como soportes en co-cultivo celular indirecto.

Herrero Herrero, María (Universitat Politècnica de València, 2022-12-23)

[ES] El desarrollo de la sociedad ha estado siempre ligado a los avances científicos y tecnológicos. Sin embargo, algunos de estos avances han supuesto la aparición de nuevos problemas, sobre todo de tipo ético, dando lugar ...
Desarrollo de nanopartículas de silicio poroso para aplicaciones de carga-liberación de medicamentos

Balaguer Garín, Paula (Universitat Politècnica de València, 2021-10-11)

[ES] Los materiales porosos han despertado un gran interés recientemente por las atrayentes ventajas que ofrecen, como por ejemplo su gran relación superficie-volumen, la capacidad de cargarlos con distintas sustancias, o ...
Design and development of new bio-gated nanodevices for targeted controlled drug release

Ultimo, Amelia (Universitat Politècnica de València, 2019-10-28)

[ES] La presente tesis doctoral, titulada "Diseño y desarrollo de nuevos nanodispositivos con puertas biomoleculares para la liberación dirigida y controlada de fármacos", está centrada en el diseño, síntesis, caracterización ...
Development of polyvinyl alcohol-based electrospinning membranes for controlled drug delivery

Mares Bou, Sofía (Universitat Politècnica de València, 2022-10-19)

[ES] El alcohol polivinílico (PVA) es un polímero sintético biodegradable y biocompatible que se ha utilizado en diversas aplicaciones médicas, entre ellas su uso como vehículo para la administración controlada de fármacos. ...
Diseño de una bomba osmótica para la distribución de fármacos en pacientes con disfunciones cardiacas

Rodrigo Roca, Rubén (Universitat Politècnica de València, 2021-10-26)

[ES] Cada vez más la ingeniería química permite avanzar en el desarrollo de dispositivos en el área biomédica. En este proyecto se estudian los sistemas de distribución de fármacos en el organismo humano en términos de ...
Drug delivery nanosystems for the localized treatment of glioblastoma multiforme

Nam, L.; Coll Merino, Mª Carmen; Erthal, L.C.S.; De La Torre-Paredes, Cristina; Serrano,D.; Martínez-Máñez, Ramón; Santos-Martinez, M.J.; Ruiz Hernández, E. (MDPI AG, 2018-05)

[EN] Glioblastoma multiforme is one of the most prevalent and malignant forms of central nervous system tumors. The treatment of glioblastoma remains a great challenge due to its location in the intracranial space and the ...
Dual enzyme-triggered controlled release on capped nanometric silica mesoporous supports

Agostini, Alessandro; Mondragón Martínez, Laura; Coll Merino, Mª Carmen; Aznar Gimeno, Elena; Marcos Martínez, María Dolores; Martínez Mañez, Ramón; Sancenón Galarza, Félix; Soto Camino, Juan; Pérez Payá, Enrique; Amoros del Toro, Pedro (Wiley Open Access, 2012)
Effect of surface properties in protein corona development on mesoporous silica nanoparticles

CLEMMENTS, ALDEN MICHAEL; Muniesa Lajara, Carlos; Landry, Christopher Caron; Botella Asuncion, Pablo (Royal Society of Chemistry, 2014)

[EN] The composition of the protein corona formed on mesoporous silica nanoparticles with several surface modifications was characterized. Low MW serum proteins were preferentially adsorbed, and PEGylated nanoparticles did ...
Electrospun PVA/Bentonite Nanocomposites Mats for Drug Delivery

Ferrández-Rives, M.; Beltrán-Osuna, A.A.; Gómez-Tejedor, José Antonio; Gómez Ribelles, José Luís (MDPI AG, 2017)

[EN] Electrospun mats and films of polyvinyl alcohol (PVA) hydrogel are produced for drug delivery. To provide mechanical consistency to the gel a reinforcement by nanoclays is introduced in the polymer matrix. Four different ...
Emulsion based microencapsulation of proteins in poly(L-lactic acid) films and membranes for the controlled release of drugs

Delmote, Josephine; Teruel-Biosca, Laura; Gómez Ribelles, José Luís; Gallego Ferrer, Gloria (Elsevier, 2017)

[EN] The aim of this study was to develop micro- or macro-porous substrates of poly(L-lactic acid) (PLLA) for the sustained release of water-soluble proteins. A model protein, bovine serum albumin (BSA), was incorporated ...
Enzyme-Responsive Silica Mesoporous Supports Capped with Azopyridinium Salts for Controlled Delivery Applications

Mas Font, Nuria; Agostini, Alessandro; Mondragón Martínez, Laura; Bernardos Bau, Andrea; Sancenón Galarza, Félix; Marcos Martínez, María Dolores; Martínez Mañez, Ramón; Costero Nieto, Ana María; Gil Grau, Salvador; Merino Sanjuán, María Matilde; Amoros del Toro, Pedro Jose; Orzáez Calatayud, Mar; Pérez Payá, Enrique (Wiley-VCH Verlag, 2012-12-07)

The preparation of a new capped silica mesoporous material, Rh-Azo-S, for on-command delivery applications in the presence of target enzymes is described. The material consists of nanometric mesoporous MCM-41-like supports ...
epsilon-Polylysine-Capped Mesoporous Silica Nanoparticles as Carrier of the C9h Peptide to Induce Apoptosis in Cancer Cells

De La Torre-Paredes, Cristina; Domínguez-Berrocal, L.; Murguía, Jose R.; Marcos Martínez, María Dolores; Martínez-Máñez, Ramón; Bravo,J.; Sancenón Galarza, Félix (John Wiley & Sons, 2018-02)

[EN] Apoptotic signaling pathways are altered in numerous pathologies such as cancer. In this scenario, caspase-9/PP2Ac alpha interaction constitutes a key target with pharmacological interest to re-establish apoptosis in ...
Finely tuned temperature-controlled cargo release using paraffin-capped mesoporous silica nanoparticles

Aznar Gimeno, Elena; Mondragón Martínez, Laura; Ros-Lis, José Vicente; Sancenón Galarza, Félix; Marcos Martínez, María Dolores; Martínez Mañez, Ramón; Soto Camino, Juan; Pérez Payá, Enrique; AMOROS DEL TORO, PEDRO (Wiley-VCH Verlag, 2011-09-27)

Trapped: Mesoporous silica nanoparticles were loaded with a fluorescent guest and functionalized with octadecyltrimethoxysilane. The alkyl chains interact with paraffins, which build a hydrophobic layer around the particle ...
Finely Tuned Temperature-Controlled Cargo Release Using Paraffin-Capped Mesoporous Silica Nanoparticles

Aznar Gimeno, Elena; Mondragón Martínez, Laura; Ros-Lis, José Vicente; Sancenón Galarza, Félix; Marcos Martínez, María Dolores; Martínez Mañez, Ramón; Soto Camino, Juan; Pérez Payá, Enrique; Amoros del Toro, Pedro Jose (Wiley-VCH Verlag, 2011-11-18)

[EN] Trapped: Mesoporous silica nanoparticles were loaded with a fluorescent guest and functionalized with octadecyltrimethoxysilane. The alkyl chains interact with paraffins, which build a hydrophobic layer around the ...
Gated Mesoporous Silica Nanocarriers for a "two-Step" Targeted System to Colonic Tissue

Gonzalez-Alvarez, Marta; Coll Merino, Mª Carmen; Gonzalez-Alvarez, Isabel; Giménez Morales, Cristina; Aznar, Elena; Martínez-Bisbal, M.Carmen; Lozoya Agulló, Isabel; Bermejo, M.; Martínez-Máñez, Ramón; Sancenón Galarza, Félix (American Chemical Society, 2017)

[EN] Colon targeted drug delivery is highly relevant not only to treat colonic local diseases but also for systemic therapies. Mesoporous silica nanoparticles (MSNs) have been demonstrated as useful systems for controlled ...