Terrés Haro, José Manuel

Organizational Units

Organizational Unit

Departamento de Ingeniería Electrónica

Organizational Unit

Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial

Organizational Unit

Instituto Universitario de Automática e Informática Industrial

Organizational Unit

Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico

ORCID

0000-0001-5794-7332

Panorama page

https://www.upv.es/ficha-personal/joterha

Search Results

Now showing 1 - 10 of 14

Finite Element Models of Gold Nanoparticles and Their Suspensions for Photothermal Effect Calculation
(MDPI AG, 2023-02-09) Terrés Haro, José Manuel; Monreal Trigo, Javier; Hernández Montoto, Andy; Ibáñez Civera, Francisco Javier; Masot Peris, Rafael; Martínez Mañez, Ramón; Departamento de Ingeniería Electrónica; Escuela Técnica Superior de Ingeniería de Telecomunicación; Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial; Departamento de Química; Instituto Universitario de Automática e Informática Industrial; Escuela Técnica Superior de Ingeniería Industrial; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico; Instituto de Instrumentación para Imagen Molecular; Escuela de Doctorado; European Commission; GENERALITAT VALENCIANA; AGENCIA ESTATAL DE INVESTIGACION; MINISTERIO DE CIENCIA E INNOVACION; Universitat Politècnica de València
[EN] (1) Background: The ability of metal nanoparticles to carry other molecules and their electromagnetic interactions can be used for localized drug release or to heat malignant tissue, as in the case of photothermal treatments. Plasmonics can be used to calculate their absorption and electric field enhancement, which can be further used to predict the outcome of photothermal experiments. In this study, we model the nanoparticle geometry in a Finite Element Model calculus environment to calculate the effects that occur as a response to placing it in an optical, electromagnetic field, and also a model of the experimental procedure to measure the temperature rise while irradiating a suspension of nanoparticles. (2) Methods: Finite Element Method numerical models using the COMSOL interface for geometry and mesh generation and iterative solving discretized Maxwell's equations; (3) Results: Absorption and scattering cross-section spectrums were obtained for NanoRods and NanoStars, also varying their geometry as a parameter, along with electric field enhancement in their surroundings; temperature curves were calculated and measured as an outcome of the irradiation of different concentration suspensions; (4) Conclusions: The results obtained are comparable with the bibliography and experimental measurements.
Janus Gold Nanostars-Mesoporous Silica Nanoparticles for NIR-Light-Triggered Drug Delivery
(John Wiley & Sons, 2019-05-27) Hernández Montoto, Andy; Llopis Lorente, Antoni; Gorbe, Mónica; Terrés Haro, José Manuel; Cao Milán, Roberto; Díaz de Greñu-Puertas, Borja; Alfonso-Navarro, María; Ibáñez Civera, Francisco Javier; Marcos Martínez, María Dolores; Orzaez, Mar; Villalonga, R.; Martínez Mañez, Ramón; Sancenón Galarza, Félix; Departamento de Ingeniería Electrónica; Escuela Técnica Superior de Ingeniería de Telecomunicación; Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial; Departamento de Química; Instituto Universitario de Automática e Informática Industrial; Escuela Técnica Superior de Ingeniería de Edificación; Escuela Técnica Superior de Ingeniería Industrial; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico; European Commission; Generalitat Valenciana; Fundació Bancària Caixa d'Estalvis i Pensions de Barcelona; Agencia Estatal de Investigación; Ministerio de Economía y Competitividad
[EN] Janus gold nanostar-mesoporous silica nanoparticle (AuNSt-MSNP) nanodevices able to release an entrapped payload upon irradiation with near infrared (NIR) light were prepared and characterized. The AuNSt surface was functionalized with a thiolated photolabile molecule (5), whereas the mesoporous silica face was loaded with a model drug (doxorubicin) and capped with proton-responsive benzimidazole-beta-cyclodextrin supramolecular gatekeepers (N 1). Upon irradiation with NIR-light, the photolabile compound 5 photodissociated, resulting in the formation of succinic acid, which induced the opening of the gatekeeper and cargo delivery. In the overall mechanism, the gold surface acts as a photochemical transducer capable of transforming the NIR-light input into a chemical messenger (succinic acid) that opens the supramolecular nanovalve. The prepared hybrid nanoparticles were non-cytotoxic to HeLa cells, until they were irradiated with a NIR laser, which led to intracellular doxorubicin release and hyperthermia. This induced a remarkable reduction in HeLa cells viability.
Validation of an automated system for the experimentation of photothermal therapies on cell cultures
(Elsevier, 2022-04-16) Terrés Haro, José Manuel; Hernández Montoto, Andy; Pardo-Huguet, María; De La Torre, Cristina; Monreal Trigo, Javier; Ibáñez Civera, Francisco Javier; Masot Peris, Rafael; Martínez Mañez, Ramón; García Breijo, Eduardo; Departamento de Ingeniería Electrónica; Escuela Técnica Superior de Ingeniería de Telecomunicación; Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial; Departamento de Química; Instituto Universitario de Automática e Informática Industrial; Escuela Técnica Superior de Ingeniería Industrial; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico; Instituto de Instrumentación para Imagen Molecular; Escuela de Doctorado; GENERALITAT VALENCIANA; AGENCIA ESTATAL DE INVESTIGACION; Universitat Politècnica de València; MINISTERIO DE CIENCIA INNOVACION Y UNIVERSIDADES
[EN] Hyperthermia is a technique used in treatments against cancer, consisting in heating the cancerous tissue to 40-44 ºC to produce apoptosis. The addition of noble metal nanoparticles would suppose a great progress in this technique development, due to their ability to produce heat or release drugs in or near the cancer cells when irradiated at a certain wavelength. This paper presents the validation of a prototype automated system for the basic experimentation of hyperthermia mediated by nanoparticles on cell cultures. It consists of a laser beam irradiating the samples placed in a 2D moving mechanism, an ambient temperature control to keep the samples in an incubation temperature range, and a thermographic camera to measure the temperature achieved. The system is controlled from a computer by a graphical user interface. The validation is done first in a suspension of gold nanostars and water to validate the temperature ranges, and then in SK-Mel and HeLa cell cultures, with varying concentrations and exposure times and measuring the cell viability 24 h after. These experiments showed that the treatment is possible and will cause cell death within a certain range of the variables to be applied. Also, an in-silico model of gold nanoparticle and its suspension in water was developed to try to predict the temperatures achieved during the treatment. The results of this model simulations are compared with the experiment results.
Diseño y desarrollo de un equipo de laboratorio para hipertermia óptica con posicionamiento de muestra o interfaz gráfica de usuario
(Universitat Politècnica de València, 2018-10-04) Terrés Haro, José Manuel; Masot Peris, Rafael; Ibáñez Civera, Francisco Javier; Trénor Gomis, Beatriz Ana; Departamento de Ingeniería Electrónica; Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial; Instituto Universitario de Automática e Informática Industrial; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico; Centro de Investigación e Innovación en Bioingeniería
[ES] La hipertermia óptica se postula como una nueva forma de tratar los procesos tumorales. Mediante el uso de un haz de luz láser y nanopartículas metálicas, diseñadas específicamente para que la resonancia de plasmón de superficie se encuentre en la longitud de onda de dicho láser, se logra un aumento de temperatura tanto en la superficie como en el entorno de estas nanopartículas. Este aumento de temperatura se puede usar directamente para atacar el tejido enfermo, que resultará dañado, no así como el tejido sano, que acumula una menor concentración de nanopartículas y es capaz de disipar mejor el calor generado y asimilar los posibles daños. Otra técnica complementaria es el uso de nanopartículas funcionalizadas y cargadas con fármacos, que son liberados en el momento de la irradiación, aumentando la eficacia del tratamiento. Sin embargo, antes de poder utilizar estas técnicas en la práctica clínica hay muchos interrogantes e inconvenientes que deben resolverse, por ello, se encuentran actualmente en fases de experimentación preclínica. En el Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM) se realizan experimentos in vitro con células y nanopartículas de oro para determinar la toxicidad de estos tratamientos. El IDM dispone de un equipo que no se diseñó inicialmente con un propósito tan amplio, y por ello ha surgido la necesidad de renovarlo. El objetivo del presente trabajo es desarrollar un nuevo equipo basado en los requerimientos que los investigadores han puesto en conocimiento del Instituto, para realizar experimentos de hipertermia óptica con una mayor facilidad y control sobre algunas de las variables que afectan a los resultados obtenidos. Para ello, se divide el trabajo en tres partes fundamentales: sistema electrónico de control de las variables del experimento, sistema electromecánico de posicionamiento de muestras, e interfaz gráfica de usuario. La novedad aportada se basa en la integración de todos los sistemas en un único equipo, el posicionamiento de muestras y la comodidad del uso de una interfaz gráfica. Se le ha dado al diseño un carácter escalable y fácilmente adaptable a los siguientes niveles de investigación clínica. Para finalizar, se ha realizado una demostración del posicionamiento de muestras y la irradiación de nanopartículas de oro en un medio acuoso, obteniendo el calentamiento del medio.
The first time on the other side: PhD candidates experience in digital electronics practical sessions and final project
(IATED, 2020-03-04) Terrés Haro, José Manuel; Monreal Trigo, Javier; Ibáñez Civera, Francisco Javier; Gil Sánchez, Luís; García Breijo, Eduardo; Laguarda Miró, Nicolás; Departamento de Ingeniería Química y Nuclear; Departamento de Ingeniería Electrónica; Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial; Instituto Universitario de Automática e Informática Industrial; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico; Instituto de Instrumentación para Imagen Molecular; Escuela de Doctorado
[EN] The university Lecturer Training Fellowship granted by the Spanish Ministry of Education implies the participation of the PhD candidates in the practical lessons of subjects related to their specialty. For the first time, two students were assigned to the high performance group in Digital Electronics in the Industrial Electronics and Automation degree, taught in the School of Design Engineering (ETSID) of the Universitat Politècnica de València (UPV). Taking advantage of the PhD candidates¿ easiness for comprehending the student¿s point of view, they were allowed to suggest and implement methodological modifications with the aim of improving the knowledge and skill transfer in the subject field. The main result was the development of a methodology which relates the practical and theoretical parts so they are interleaved, making it easier to comprehend, assimilate the concepts, and participate actively in the practical part gaining experience in the field. The subject is divided in three main parts: VHDL, microcontrollers and a final project. One of the PhD students was assigned to the VHDL part, the other one to the microcontroller part, and the final project was collaborative, with both participating in the organization and evaluation. This final project evaluates the innovation, creativity and entrepreneurship transversal skills of the students by entrusting them to develop a microcontroller code and to write the documentation about it, while participating in a car-like robot competition. This year, the competition was presented as a list of requirements the robots must meet before the deadline to access the ¿final test¿, in a way that was first implemented by the successful aerospace company SpaceX for the international Hyperloop Pod Competition series. This makes the deadlines and evaluation items very clear for both students and evaluators while leaving the door open to different ways of implementation using the knowledge acquired through the semester. This paper presents the thought process behind the methodology used during the subject and final project and the results obtained, alongside with the experience reported by both students and PhD intraining candidates.
Gold Nanostars Coated with Mesoporous Silica Are Effective and Nontoxic Photothermal Agents Capable of Gate Keeping and Laser Induced Drug Release
(American Chemical Society, 2018-08) Hernández Montoto, Andy; Montes-Robles, Roberto; Samadi, Akbar; Gorbe, Mónica; Terrés Haro, José Manuel; Cao Milán, Roberto; Aznar Gimeno, Elena; Ibáñez Civera, Francisco Javier; Masot Peris, Rafael; Marcos Martínez, María Dolores; Orzáez, Mar; Sancenón Galarza, Félix; Oddershede, L.B.; Martínez Mañez, Ramón; Departamento de Ingeniería Electrónica; Escuela Técnica Superior de Ingeniería de Telecomunicación; Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial; Departamento de Química; Instituto Universitario de Automática e Informática Industrial; Escuela Técnica Superior de Ingeniería Industrial; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico; Generalitat Valenciana; Danish National Research Foundation; Novo Nordisk Foundation, Dinamarca; Education, Audiovisual and Culture Executive Agency; Ministerio de Economía y Competitividad
[EN] Herein, a novel drug photorelease system based on gold nanostars (AuNSts), coated with a mesoporous silica shell and capped with paraffin as thermosensitive molecular gate, is reported. Direct measurements of the surface temperature of a single gold nanostar irradiated using a tightly focused laser beam are performed via a heat sensitive biological matrix. The surface temperature of a AuNSt increases by hundreds of degrees (degrees C) even at low laser powers. AuNSts coated with a mesoporous silica shell using a surfactant-templated synthesis are used as chemotherapeutic nanocarriers. Synthetic parameters are optimized to d avoid AuNSt reshaping, and thus to obtain nanoparticles with suitable and stable plasmonic properties for near-infrared (NIR) laser-triggered cargo delivery. The mesoporous silica-coated nanostars are loaded with doxorubicin (Dox) and coated with octadecyltrimethoxysilane and the paraffin heneicosane. The paraffin molecules formed a hydrophobic layer that blocks the pores, impeding the release of the cargo. This hybrid nanosystem exhibits a well-defined photodelivery profile using NIR radiation, even at low power density, whereas the nonirradiated sample shows a negligible payload release. Dox-loaded nanoparticles displayed no cytotoxicity toward HeLa cells, until they are irradiated with 808 nm laser, provoking paraffin melting and drug release. Hence, these novel, functional, and biocompatible nanoparticles display adequate plasmonic properties for NIR-triggered drug photorelease applications.
A NIR light-triggered drug delivery system using core-shell gold nanostars-mesoporous silica nanoparticles based on multiphoton absorption photo-dissociation of 2-nitrobenzyl PEG
(The Royal Society of Chemistry, 2019-08-07) Hernández Montoto, Andy; Gorbe, Mónica; Llopis Lorente, Antoni; Terrés Haro, José Manuel; Montes-Robles, Roberto; Cao Milán, Roberto; Díaz de Greñu-Puertas, Borja; Alfonso-Navarro, María; Orzaez, Mar; Marcos Martínez, María Dolores; Martínez Mañez, Ramón; Sancenón Galarza, Félix; Departamento de Ingeniería Electrónica; Escuela Técnica Superior de Ingeniería de Telecomunicación; Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial; Departamento de Química; Instituto Universitario de Automática e Informática Industrial; Escuela Técnica Superior de Ingeniería de Edificación; Escuela Técnica Superior de Ingeniería Industrial; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico; Generalitat Valenciana; Agencia Estatal de Investigación; Education, Audiovisual and Culture Executive Agency
[EN] Gold nanostars coated with a mesoporous silica shell and functionalized with poly(ethylene glycol) containing photolabile 2-nitrobenzyl moieties are able to release doxorubicin after NIR light irradiation at low power irradiance via a multiphoton absorption photo-dissociation process.
The interview as a learning tool: an experience of emotional motivation in engineering degrees
(IATED, 2020-03-04) Laguarda Miró, Nicolás; Terrés Haro, José Manuel; Monreal Trigo, Javier; Ibáñez Civera, Francisco Javier; Gil Sánchez, Luís; Olguín Pinatti, Cristian Ariel; Departamento de Ingeniería Química y Nuclear; Departamento de Ingeniería Electrónica; Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial; Instituto Universitario de Automática e Informática Industrial; Escuela Técnica Superior de Ingeniería Industrial; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico; Instituto de Instrumentación para Imagen Molecular; Escuela de Doctorado
[EN] Technical studies in Higher Education have traditionally been seen as complex, difficult and abstract by students, and particularly when compared to university careers in the field of humanities, more related to social and human aspects. In the line of innovating in the field of engineering teaching, and with the intention of bringing engineering and learning strategies based on the social, this paper presents an experience of motivation and emotional bonding of students with their degrees in the field of industrial and aeronautical engineering. In this experience, the interview has been used as an educational tool. So, it has been applied to a very specific topic (sustainability and development in the industrial age) of the subject Sustainable Development and Environmental Ethics, included in the program of all the degrees at the School of Design Engineering of the Universitat Politècnica del València. The experience consisted in interviewing a family member or close person who had lived the industrialization age in the Spanish countryside, in order to enrichen the contents given at class with the personal experience of the interviewed relative. As a result, the experience is considered very satisfactory by the students as it allows them to reinforce the knowledge acquired in in the classroom being able to link theory to the personal experiences by people close to them who had the chance to experience the emergence of industrialization in the Spanish countryside. Thus, the interview provides students an emotional bond with the matter they are studying, achieving at least three main objectives, as the experience: 1) lets the students know about real experiences by relatives or close people in the industrialization age in Spain, 2) facilitates the contextualization of the matter in this specific historical period and 3) motivates the students to the subject and their careers.
Sistemas optoelectrónicos para terapias fototérmicas dirigidas al cáncer de piel y optogenética en la regeneración de tejido nervioso
(Universitat Politècnica de València, 2024-01-23) Terrés Haro, José Manuel; García Breijo, Eduardo; Ibáñez Civera, Francisco Javier; Masot Peris, Rafael; Departamento de Ingeniería Electrónica; Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial; Instituto Universitario de Automática e Informática Industrial; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico; Ministerio de Ciencia e Innovación; Generalitat Valenciana; European Commission; Agencia Estatal de Investigación
[ES] Esta tesis doctoral se enfoca en la creación y validación de sistemas optoelectrónicos para aplicaciones biomédicas, en concreto para la terapia fototérmica contra el cáncer de piel y la optogenética para la regeneración de tejido nervioso. En su transcurso, se ha desarrollado un conjunto de herramientas y dispositivos que abarcan desde la experimentación sobre cultivos celulares hasta modelos computacionales que simulan el tratamiento. Para la terapia fototérmica, se ha diseñado y construido un equipo de experimentación in vitro validado sobre cultivos celulares. Este dispositivo, equipado con funcionalidades para controlar la potencia del láser, gestionar los tiempos de irradiación, realizar un posicionamiento automático de varias muestras bajo el haz, y monitorizar la evolución de la temperatura, se presenta como una herramienta altamente beneficiosa para la investigación en esta área. Después, se exploró la simulación mediante el Método de Elementos Finitos para analizar el comportamiento de las nanopartículas y sus suspensiones en agua, arrojando luz sobre sus potenciales aplicaciones en terapias fototérmicas y campos relacionados. Gracias al aprendizaje obtenido en los primeros pasos de este estudio, se logró el desarrollo de dos nuevos equipos que habilitan la realización de experimentos in vivo. Además, se ha implementado un modelo computacional diseñado para investigar el impacto de la terapia fototérmica en tejido biológico. Por último, se desarrolló un dispositivo optoelectrónico de reducidas dimensiones y alta potencia para la estimulación optogenética de neuronas modificadas genéticamente, con el objetivo de observar el transitorio de la estimulación y así entender en mayor medida las posibilidades que ofrece la optogenética en el campo de la regeneración de tejidos.
Redesigning seminars in the subject sustainable development and environmental ethics for the new on-line higher education scenario due to COVID-19
(IATED, 2021-03-09) Laguarda Miró, Nicolás; Ibáñez Civera, Francisco Javier; Gil Sánchez, Luís; García Breijo, Eduardo; Monreal Trigo, Javier; Terrés Haro, José Manuel; Departamento de Ingeniería Química y Nuclear; Departamento de Ingeniería Electrónica; Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial; Instituto Universitario de Automática e Informática Industrial; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico; Instituto de Instrumentación para Imagen Molecular; Escuela de Doctorado
[EN] Covid-19 has changed the global agenda this year 2020 and particularly since March when the disease disseminated and affected the whole world. Then, confinement strategies started in most of the countries affecting important humankind aspects such as economy, society, and many others. In an educational point of view, higher education has been suddenly forced to change from a traditional presential education structure to a non-presential learning-teaching framework based on virtual/on-line educational strategies. Particular efforts have been done at the Universitat Politècnica de València (UPV) and in its Design Engineering School (ETSID) to adapt their educational model to this unexpected situation. This paper shows the work conducted to redesign seminars in the subject Sustainable Development and Environmental Ethics according to the requirements of this new scenario. A preliminary SWOT analysis allowed to focus our redesigning efforts in specific aspects of the seminar: assuming the nonpresential scenario and adapting to this new reality, an appropriate and more effective information sharing, some visual aspects associated to the specific teamworking dynamics in the classroom, structure and seminar schedule were some of the aspects to be on in the redesigning process. Students¿ opinions and point of view were particularly considered in redesigning as they are intensively experiencing on-line education since confinement started. Finally, structure, tasks, schedule, attendance, results compilation and sharing, and assessment were completely reconsidered and adapted. After this season¿s experience, development, results and students¿ feedback have been studied in depth. As a conclusion, the new redesigned seminar rises as a successful improved version of the activity being more dynamic, participative, and educationally functional. Although, there are important aspects that have been lost because they are linked to presential attendance and real teamworking in the classroom. Further efforts will be focused in diminishing these disadvantages.