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Assessment of safety margins of exposure to non-genotoxic chemical substances in food

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Assessment of safety margins of exposure to non-genotoxic chemical substances in food

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dc.contributor.author Doménech Antich, Eva Mª es_ES
dc.contributor.author Martorell Alsina, Sebastián Salvador es_ES
dc.date.accessioned 2018-06-18T04:25:53Z
dc.date.available 2018-06-18T04:25:53Z
dc.date.issued 2017 es_ES
dc.identifier.issn 0956-7135 es_ES
dc.identifier.uri http://hdl.handle.net/10251/104254
dc.description.abstract [EN] The concept of Food Safety Margin (FSM) was introduced in microbiological risk analysis as an alternative approach to risk characterization within the informed-risk decision-making process. Its aim was to verify compliance with food safety objectives by assessing the effects of uncertainties. This paper describes the fundamentals and develop a new formulation of safety margins to verify compliance with food safety goals in relation to exposure to non-genotoxic chemical hazards. Both classical and probabilistic metrics were used to compare a given exposure to an estimated daily intake (EDI) with a given safety goal, the acceptable daily intake (ADI). The safety margins of these metrics were assessed in the exposure of peaches to organophosphorus pesticides. The pesticides considered were Azinphos-methyl, Chlorpyrifos, Diazinon, Dimethoate, Methamidophos, Parathion-methyl and Phosmet. The concentrations were obtained from the USDA pesticide database. The study period included the 11 years in which peaches were analysed from 1994 to 2014. The results show the importance of using the effect of uncertainty instead of mean values for risk characterization and that not only safety margins increased during this period but also that uncertainty was reduced. In general, large safety margins were observed in the period studied and few situations were found in which exposure was outside the safety limits. (C) 2017 Elsevier Ltd. All rights reserved. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Food Control es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Daily intake es_ES
dc.subject EDI es_ES
dc.subject ADI es_ES
dc.subject Safety margin metrics es_ES
dc.subject Food es_ES
dc.subject Organophosphorus pesticides es_ES
dc.subject Peaches es_ES
dc.subject Risk assessment es_ES
dc.subject Risk characterization es_ES
dc.subject Risk-informed decision-making es_ES
dc.subject.classification INGENIERIA NUCLEAR es_ES
dc.subject.classification TECNOLOGIA DE ALIMENTOS es_ES
dc.title Assessment of safety margins of exposure to non-genotoxic chemical substances in food es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.foodcont.2017.03.018 es_ES
dc.rights.accessRights Abierto es_ES
dc.date.embargoEndDate 2018-09-01 es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Química y Nuclear - Departament d'Enginyeria Química i Nuclear es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Tecnología de Alimentos - Departament de Tecnologia d'Aliments es_ES
dc.description.bibliographicCitation Doménech Antich, EM.; Martorell Alsina, SS. (2017). Assessment of safety margins of exposure to non-genotoxic chemical substances in food. Food Control. 79:1-9. doi:10.1016/j.foodcont.2017.03.018 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.1016/j.foodcont.2017.03.018 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 9 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 79 es_ES
dc.relation.pasarela S\337405 es_ES


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