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High Efficiency Microwave Flow Chemistry Towards Synthesis of Functional Materials and Pharmaceutical Cores

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High Efficiency Microwave Flow Chemistry Towards Synthesis of Functional Materials and Pharmaceutical Cores

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dc.contributor.author Barham, Joshua es_ES
dc.contributor.author Koyama, Emiko es_ES
dc.contributor.author Sugiyama, Jun-ichi es_ES
dc.contributor.author Norikane, Yasuo es_ES
dc.contributor.author Egami, Hiromichi es_ES
dc.contributor.author Hamashima, Yoshitaka es_ES
dc.date.accessioned 2019-11-11T16:01:19Z
dc.date.available 2019-11-11T16:01:19Z
dc.date.issued 2019-10-15
dc.identifier.isbn 9788490487198
dc.identifier.uri http://hdl.handle.net/10251/130754
dc.description.abstract [EN] Microwave (MW) heating benefits organic synthesis by affording higher product yields in shorter time periods than conventional heating, yet it suffers from poor scalability and is limited to polar solvents in typical batch mode reactors. Herein, we report a microwave flow reactor using a solid-state semiconductor MW generator. The tunable, single-mode MW heating allows high efficiency, scalable organic synthesis, rapid reaction optimization and is applicable to non-polar solvents (o-Xylene and CPME can be rapidly heated to ca. 260 oC). Auto-frequency tuning compensates for changes in the microwave absorption properties (permittivity, epsilon) with increasing temperature, affording excellent temperature and process control. This technology unlocked unprecedented g/h productivity of C60/fullerene-indene monoadduct (IC60MA) and facilitated a novel, transition metal-free amide-styrene coupling reaction for synthesis of amide-containing pharmaceutical cores in up to 65 g/h (Figure 1). An ortho-Claisen rearrangement reaction was rapidly optimised. es_ES
dc.description.sponsorship The authors gratefully acknowledge the technical support from the National Institute of Advanced Industrial Science and Technology and the University of Shizuoka, as well as financial support from NEDO, Shizuoka Prefectural Government. Joshua P. Barham is grateful for financial support from JSPS (KAKENHI Grant Number JP18F19030). The authors are grateful for Shizuoka University (Prof. Noboyuki Mase’s group) and Gifu Pharmaceutical University (Prof. Hironao Sajiki’s group) for their research in this area. es_ES
dc.format.extent 9 es_ES
dc.language Inglés es_ES
dc.publisher Editorial Universitat Politècnica de València es_ES
dc.relation JSPS/JP18F19030
dc.relation.ispartof AMPERE 2019. 17th International Conference on Microwave and High Frequency Heating es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Energy Production by Microwaves es_ES
dc.subject Microwave CVD es_ES
dc.subject EM Modelling es_ES
dc.subject Microwave Material interaction es_ES
dc.subject Dielectric Properties es_ES
dc.subject Dielectric Properties Measurement es_ES
dc.subject Solid State Microwave es_ES
dc.subject Microwave Processing es_ES
dc.subject Microwave Chemistry es_ES
dc.subject Microwave applicators design es_ES
dc.title High Efficiency Microwave Flow Chemistry Towards Synthesis of Functional Materials and Pharmaceutical Cores es_ES
dc.type Capítulo de libro es_ES
dc.type Comunicación en congreso es_ES
dc.identifier.doi 10.4995/AMPERE2019.2019.9860
dc.rights.accessRights Abierto es_ES
dc.description.bibliographicCitation Barham, J.; Koyama, E.; Sugiyama, J.; Norikane, Y.; Egami, H.; Hamashima, Y. (2019). High Efficiency Microwave Flow Chemistry Towards Synthesis of Functional Materials and Pharmaceutical Cores. En AMPERE 2019. 17th International Conference on Microwave and High Frequency Heating. Editorial Universitat Politècnica de València. 409-417. https://doi.org/10.4995/AMPERE2019.2019.9860 es_ES
dc.description.accrualMethod OCS es_ES
dc.relation.conferencename Ampere 2019 es_ES
dc.relation.conferencedate Septiembre 09-12,2019 es_ES
dc.relation.conferenceplace Valencia, Spain es_ES
dc.relation.publisherversion http://ocs.editorial.upv.es/index.php/AMPERE2019/AMPERE2019/paper/view/9860 es_ES
dc.description.upvformatpinicio 409 es_ES
dc.description.upvformatpfin 417 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.relation.pasarela OCS\9860 es_ES
dc.contributor.funder New Energy and Industrial Technology Development Organization
dc.contributor.funder Japan Society for the Promotion of Science


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