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dc.contributor.author | Barham, Joshua | es_ES |
dc.contributor.author | Koyama, Emiko | es_ES |
dc.contributor.author | Sugiyama, Jun-ichi | es_ES |
dc.contributor.author | Norikane, Yasuo | es_ES |
dc.contributor.author | Egami, Hiromichi | es_ES |
dc.contributor.author | Hamashima, Yoshitaka | es_ES |
dc.date.accessioned | 2019-11-11T16:01:19Z | |
dc.date.available | 2019-11-11T16:01:19Z | |
dc.date.issued | 2019-10-15 | |
dc.identifier.isbn | 9788490487198 | |
dc.identifier.uri | http://hdl.handle.net/10251/130754 | |
dc.description.abstract | [EN] Microwave (MW) heating benefits organic synthesis by affording higher product yields in shorter time periods than conventional heating, yet it suffers from poor scalability and is limited to polar solvents in typical batch mode reactors. Herein, we report a microwave flow reactor using a solid-state semiconductor MW generator. The tunable, single-mode MW heating allows high efficiency, scalable organic synthesis, rapid reaction optimization and is applicable to non-polar solvents (o-Xylene and CPME can be rapidly heated to ca. 260 oC). Auto-frequency tuning compensates for changes in the microwave absorption properties (permittivity, epsilon) with increasing temperature, affording excellent temperature and process control. This technology unlocked unprecedented g/h productivity of C60/fullerene-indene monoadduct (IC60MA) and facilitated a novel, transition metal-free amide-styrene coupling reaction for synthesis of amide-containing pharmaceutical cores in up to 65 g/h (Figure 1). An ortho-Claisen rearrangement reaction was rapidly optimised. | es_ES |
dc.description.sponsorship | The authors gratefully acknowledge the technical support from the National Institute of Advanced Industrial Science and Technology and the University of Shizuoka, as well as financial support from NEDO, Shizuoka Prefectural Government. Joshua P. Barham is grateful for financial support from JSPS (KAKENHI Grant Number JP18F19030). The authors are grateful for Shizuoka University (Prof. Noboyuki Mase’s group) and Gifu Pharmaceutical University (Prof. Hironao Sajiki’s group) for their research in this area. | es_ES |
dc.format.extent | 9 | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Editorial Universitat Politècnica de València | es_ES |
dc.relation.ispartof | AMPERE 2019. 17th International Conference on Microwave and High Frequency Heating | es_ES |
dc.rights | Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) | es_ES |
dc.subject | Energy Production by Microwaves | es_ES |
dc.subject | Microwave CVD | es_ES |
dc.subject | EM Modelling | es_ES |
dc.subject | Microwave Material interaction | es_ES |
dc.subject | Dielectric Properties | es_ES |
dc.subject | Dielectric Properties Measurement | es_ES |
dc.subject | Solid State Microwave | es_ES |
dc.subject | Microwave Processing | es_ES |
dc.subject | Microwave Chemistry | es_ES |
dc.subject | Microwave applicators design | es_ES |
dc.title | High Efficiency Microwave Flow Chemistry Towards Synthesis of Functional Materials and Pharmaceutical Cores | es_ES |
dc.type | Capítulo de libro | es_ES |
dc.type | Comunicación en congreso | es_ES |
dc.identifier.doi | 10.4995/AMPERE2019.2019.9860 | |
dc.relation.projectID | info:eu-repo/grantAgreement/JSPS//JP18F19030/ | |
dc.rights.accessRights | Abierto | es_ES |
dc.description.bibliographicCitation | Barham, J.; Koyama, E.; Sugiyama, J.; Norikane, Y.; Egami, H.; Hamashima, Y. (2019). High Efficiency Microwave Flow Chemistry Towards Synthesis of Functional Materials and Pharmaceutical Cores. En AMPERE 2019. 17th International Conference on Microwave and High Frequency Heating. Editorial Universitat Politècnica de València. 409-417. https://doi.org/10.4995/AMPERE2019.2019.9860 | es_ES |
dc.description.accrualMethod | OCS | es_ES |
dc.relation.conferencename | Ampere 2019 | es_ES |
dc.relation.conferencedate | Septiembre 09-12,2019 | es_ES |
dc.relation.conferenceplace | Valencia, Spain | es_ES |
dc.relation.publisherversion | http://ocs.editorial.upv.es/index.php/AMPERE2019/AMPERE2019/paper/view/9860 | es_ES |
dc.description.upvformatpinicio | 409 | es_ES |
dc.description.upvformatpfin | 417 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.relation.pasarela | OCS\9860 | es_ES |
dc.contributor.funder | New Energy and Industrial Technology Development Organization, Japón | |
dc.contributor.funder | Japan Society for the Promotion of Science |