Alcaraz Tormo, MJ.; Compañ, Á.; Guillem Salazar, MI. (2019). Extracellular Vesicles from Mesenchymal Stem Cells as Novel Treatments for Musculoskeletal Diseases. Cells. 9(1):1-21. https://doi.org/10.3390/cells9010098
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/137596
Title:
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Extracellular Vesicles from Mesenchymal Stem Cells as Novel Treatments for Musculoskeletal Diseases
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Author:
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ALCARAZ TORMO, Mª JOSE
Compañ, Álvaro
Guillem Salazar, Mª Isabel
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Issued date:
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Abstract:
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[EN] Mesenchymal stem/stromal cells (MSCs) represent a promising therapy for musculoskeletal diseases. There is compelling evidence indicating that MSC effects are mainly mediated by paracrine mechanisms and in particular ...[+]
[EN] Mesenchymal stem/stromal cells (MSCs) represent a promising therapy for musculoskeletal diseases. There is compelling evidence indicating that MSC effects are mainly mediated by paracrine mechanisms and in particular by the secretion of extracellular vesicles (EVs). Many studies have thus suggested that EVs may be an alternative to cell therapy with MSCs in tissue repair. In this review, we summarize the current understanding of MSC EVs actions in preclinical studies of (1) immune regulation and rheumatoid arthritis, (2) bone repair and bone diseases, (3) cartilage repair and osteoarthritis, (4) intervertebral disk degeneration and (5) skeletal muscle and tendon repair. We also discuss the mechanisms underlying these actions and the perspectives of MSC EVs-based strategies for future treatments of musculoskeletal disorders.
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Subjects:
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Mesenchymal stem cells
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Extracellular vesicles
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Immunoregulation
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Bone diseases
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Osteoarthritis
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Copyrigths:
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Reconocimiento (by)
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Source:
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Cells. (issn:
2073-4409
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DOI:
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10.3390/cells9010098
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Publisher:
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MDPI
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Publisher version:
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https://doi.org/10.3390/cells9010098
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Project ID:
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MICIU-FEDER/SAF2017-85806-R
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Thanks:
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This work has been funded by grant SAF2017-85806-R (Ministerio de Ciencia, Innovación y
Universidades, Spain, FEDER.
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Type:
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Artículo
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