Llopis-Lorente, A.; Díez, P.; De La Torre-Paredes, C.; Sanchez, A.; Sancenón Galarza, F.; Aznar, E.; Marcos Martínez, MD.... (2017). Enzyme-Controlled Nanodevice for Acetylcholine-Triggered Cargo Delivery Based on Janus Au-Mesoporous Silica Nanoparticles. Chemistry - A European Journal. 23(18):4276-4281. https://doi.org/10.1002/chem.201700603
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/148460
Title:
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Enzyme-Controlled Nanodevice for Acetylcholine-Triggered Cargo Delivery Based on Janus Au-Mesoporous Silica Nanoparticles
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Author:
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Llopis-Lorente, Antoni
Díez, Paula
De La Torre-Paredes, Cristina
Sanchez, Alfredo
Sancenón Galarza, Félix
Aznar, Elena
Marcos Martínez, María Dolores
Martínez-Ruíz, Paloma
Martínez-Máñez, Ramón
Villalonga, Reynaldo
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UPV Unit:
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Universitat Politècnica de València. Departamento de Química - Departament de Química
Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic
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Issued date:
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Abstract:
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[EN] This work reports a new gated nanodevice for acetylcholine-triggered cargo delivery. We prepared and characterized Janus Au-mesoporous silica nanoparticles functionalized with acetylcholinesterase on the Au face and ...[+]
[EN] This work reports a new gated nanodevice for acetylcholine-triggered cargo delivery. We prepared and characterized Janus Au-mesoporous silica nanoparticles functionalized with acetylcholinesterase on the Au face and with supramolecular b-cyclodextrin: benzimidazole inclusion complexes as caps on the mesoporous silica face. The nanodevice is able to selectively deliver the cargo in the presence of acetylcholine via enzyme-mediated acetylcholine hydrolysis, locally lowering the pH and opening the supramolecular gate. Given the key role played by ACh and its relation with Parkinson's disease and other nervous system diseases, we believe that these findings could help design new therapeutic strategies.
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Subjects:
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Acetylcholine
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Controlled release
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Mesoporous materials
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Nanoparticles
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Nanotechnology
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Copyrigths:
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Reserva de todos los derechos
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Source:
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Chemistry - A European Journal. (issn:
0947-6539
)
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DOI:
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10.1002/chem.201700603
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Publisher:
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John Wiley & Sons
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Publisher version:
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https://doi.org/10.1002/chem.201700603
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Project ID:
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CAM/S2013/MIT-3029
...[+]
CAM/S2013/MIT-3029
MINECO/MAT2015-64139-C4-1-R
MINECO/MAT2012-38429-C04-01
MINECO/CTQ2014-58989-P
MINECO/CTQ2015-71936-REDT
GENERALITAT VALENCIANA/PROMETEOII/2014/047
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Description:
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"This is the peer reviewed version of the following article: Llopis-Lorente, Antoni, Paula Díez, Cristina de la Torre, Alfredo Sánchez, Félix Sancenón, Elena Aznar, María D. Marcos, Paloma Martínez-Ruíz, Ramón Martínez-Máñez, and Reynaldo Villalonga. 2017. Enzyme-Controlled Nanodevice for Acetylcholine-Triggered Cargo Delivery Based on Janus Au-Mesoporous Silica Nanoparticles. Chemistry - A European Journal 23 (18). Wiley: 4276 81. doi:10.1002/chem.201700603, which has been published in final form at https://doi.org/10.1002/chem.201700603. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
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Thanks:
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A.L.L. is grateful to "La Caixa" Banking Foundation for his PhD fellowship. The authors are gratitude to the Spanish Government (MINECO Projects MAT2012-38429-C04-01, MAT2015-64139-C4-1, CTQ2014-58989-P and CTQ2015-71936-REDT) ...[+]
A.L.L. is grateful to "La Caixa" Banking Foundation for his PhD fellowship. The authors are gratitude to the Spanish Government (MINECO Projects MAT2012-38429-C04-01, MAT2015-64139-C4-1, CTQ2014-58989-P and CTQ2015-71936-REDT) and the Generalitat Valencia (Project PROMETEOII/2014/047) for support. The Comunidad de Madrid (S2013/MIT-3029, Programme NANOAVANSENS) is also gratefully acknowledged.
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Type:
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Artículo
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