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Enzyme-Controlled Nanodevice for Acetylcholine-Triggered Cargo Delivery Based on Janus Au-Mesoporous Silica Nanoparticles

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Enzyme-Controlled Nanodevice for Acetylcholine-Triggered Cargo Delivery Based on Janus Au-Mesoporous Silica Nanoparticles

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dc.contributor.author Llopis-Lorente, Antoni es_ES
dc.contributor.author Díez, Paula es_ES
dc.contributor.author De La Torre-Paredes, Cristina es_ES
dc.contributor.author Sanchez, Alfredo es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.contributor.author Aznar, Elena es_ES
dc.contributor.author Marcos Martínez, María Dolores es_ES
dc.contributor.author Martínez-Ruíz, Paloma es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.contributor.author Villalonga, Reynaldo es_ES
dc.date.accessioned 2020-07-22T03:31:45Z
dc.date.available 2020-07-22T03:31:45Z
dc.date.issued 2017-03-28 es_ES
dc.identifier.issn 0947-6539 es_ES
dc.identifier.uri http://hdl.handle.net/10251/148460
dc.description "This is the peer reviewed version of the following article: Llopis-Lorente, Antoni, Paula Díez, Cristina de la Torre, Alfredo Sánchez, Félix Sancenón, Elena Aznar, María D. Marcos, Paloma Martínez-Ruíz, Ramón Martínez-Máñez, and Reynaldo Villalonga. 2017. Enzyme-Controlled Nanodevice for Acetylcholine-Triggered Cargo Delivery Based on Janus Au-Mesoporous Silica Nanoparticles. Chemistry - A European Journal 23 (18). Wiley: 4276 81. doi:10.1002/chem.201700603, which has been published in final form at https://doi.org/10.1002/chem.201700603. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving." es_ES
dc.description.abstract [EN] This work reports a new gated nanodevice for acetylcholine-triggered cargo delivery. We prepared and characterized Janus Au-mesoporous silica nanoparticles functionalized with acetylcholinesterase on the Au face and with supramolecular b-cyclodextrin: benzimidazole inclusion complexes as caps on the mesoporous silica face. The nanodevice is able to selectively deliver the cargo in the presence of acetylcholine via enzyme-mediated acetylcholine hydrolysis, locally lowering the pH and opening the supramolecular gate. Given the key role played by ACh and its relation with Parkinson's disease and other nervous system diseases, we believe that these findings could help design new therapeutic strategies. es_ES
dc.description.sponsorship A.L.L. is grateful to "La Caixa" Banking Foundation for his PhD fellowship. The authors are gratitude to the Spanish Government (MINECO Projects MAT2012-38429-C04-01, MAT2015-64139-C4-1, CTQ2014-58989-P and CTQ2015-71936-REDT) and the Generalitat Valencia (Project PROMETEOII/2014/047) for support. The Comunidad de Madrid (S2013/MIT-3029, Programme NANOAVANSENS) is also gratefully acknowledged. es_ES
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation.ispartof Chemistry - A European Journal es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Acetylcholine es_ES
dc.subject Controlled release es_ES
dc.subject Mesoporous materials es_ES
dc.subject Nanoparticles es_ES
dc.subject Nanotechnology es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.subject.classification CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Enzyme-Controlled Nanodevice for Acetylcholine-Triggered Cargo Delivery Based on Janus Au-Mesoporous Silica Nanoparticles es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/chem.201700603 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/CAM//S2013%2FMIT-3029/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2015-64139-C4-1-R/ES/NANOMATERIALES INTELIGENTES, SONDAS Y DISPOSITIVOS PARA EL DESARROLLO INTEGRADO DE NUEVAS HERRAMIENTAS APLICADAS AL CAMPO BIOMEDICO/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2012-38429-C04-01/ES/DESARROLLO DE MATERIALES FUNCIONALIZADOS CON PUERTAS NANOSCOPICAS PARA APLICACIONES DE LIBERACION CONTROLADA Y SENSORES PARA LA DETECCION DE NITRATO AMONICO, SULFIDRICO Y CO/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CTQ2014-58989-P/ES/BIONANORROBOTS QUIMICAMENTE PROGRAMADOS Y CONTROLADOS POR ENZIMAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CTQ2015-71936-REDT/ES/MODIFICACION QUIMICA DEL GRAFENO PARA NUEVAS PROPIEDADES Y APLICACIONES/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEOII%2F2014%2F047/ES/Nuevas aproximaciones para el diseño de materiales de liberación controlada y la detección de compuestos peligrosos/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.description.bibliographicCitation Llopis-Lorente, A.; Díez, P.; De La Torre-Paredes, C.; Sanchez, A.; Sancenón Galarza, F.; Aznar, E.; Marcos Martínez, MD.... (2017). Enzyme-Controlled Nanodevice for Acetylcholine-Triggered Cargo Delivery Based on Janus Au-Mesoporous Silica Nanoparticles. Chemistry - A European Journal. 23(18):4276-4281. https://doi.org/10.1002/chem.201700603 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1002/chem.201700603 es_ES
dc.description.upvformatpinicio 4276 es_ES
dc.description.upvformatpfin 4281 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 23 es_ES
dc.description.issue 18 es_ES
dc.identifier.pmid 28220973 es_ES
dc.relation.pasarela S\338372 es_ES
dc.contributor.funder Comunidad de Madrid es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Fundació Bancària Caixa d'Estalvis i Pensions de Barcelona es_ES
dc.description.references Gotti, C., & Clementi, F. (2004). Neuronal nicotinic receptors: from structure to pathology. Progress in Neurobiology, 74(6), 363-396. doi:10.1016/j.pneurobio.2004.09.006 es_ES
dc.description.references Lindstrom, J. (1997). Nicotinic acetylcholine receptors in health and disease. Molecular Neurobiology, 15(2), 193-222. doi:10.1007/bf02740634 es_ES
dc.description.references Descarries, L., Gisiger, V., & Steriade, M. (1997). Diffuse transmission by acetylcholine in the CNS. Progress in Neurobiology, 53(5), 603-625. doi:10.1016/s0301-0082(97)00050-6 es_ES
dc.description.references Leblond, L., Beaufort, C., Delerue, F., & Durkin, T. P. (2002). Differential roles for nicotinic and muscarinic cholinergic receptors in sustained visuo-spatial attention? A study using a 5-arm maze protocol in mice. Behavioural Brain Research, 128(1), 91-102. doi:10.1016/s0166-4328(01)00306-0 es_ES
dc.description.references Nelson, C., Burk, J., Bruno, J., & Sarter, M. (2002). Effects of acute and repeated systemic administration of ketamine on prefrontal acetylcholine release and sustained attention performance in rats. Psychopharmacology, 161(2), 168-179. doi:10.1007/s00213-002-1004-7 es_ES
dc.description.references Hasselmo, M. E., & Bower, J. M. (1993). Acetylcholine and memory. Trends in Neurosciences, 16(6), 218-222. doi:10.1016/0166-2236(93)90159-j es_ES
dc.description.references Pepeu, G. (2004). Changes in Acetylcholine Extracellular Levels During Cognitive Processes. Learning & Memory, 11(1), 21-27. doi:10.1101/lm.68104 es_ES
dc.description.references Calabresi, P., Picconi, B., Parnetti, L., & Di Filippo, M. (2006). A convergent model for cognitive dysfunctions in Parkinson’s disease: the critical dopamine–acetylcholine synaptic balance. The Lancet Neurology, 5(11), 974-983. doi:10.1016/s1474-4422(06)70600-7 es_ES
dc.description.references Ehrenstein, G., Galdzicki, Z., & Lange, G. D. (1997). The choline-leakage hypothesis for the loss of acetylcholine in Alzheimer’s disease. Biophysical Journal, 73(3), 1276-1280. doi:10.1016/s0006-3495(97)78160-8 es_ES
dc.description.references Reale, M., de Angelis, F., di Nicola, M., Capello, E., di Ioia, M., Luca, G., … Tata, A. (2012). Relation between Pro-inflammatory Cytokines and Acetylcholine Levels in Relapsing-Remitting Multiple Sclerosis Patients. International Journal of Molecular Sciences, 13(12), 12656-12664. doi:10.3390/ijms131012656 es_ES
dc.description.references Brett, R. S., Schmidt, J. H., Cage, J. S., Schartel, S. A., & Poppers, P. J. (1987). Measurement of Acetylcholine Receptor Concentration in Skeletal Muscle from a Patient with Multiple Sclerosis and Resistance to Atracurium. Anesthesiology, 66(6), 837-838. doi:10.1097/00000542-198706000-00025 es_ES
dc.description.references Picconi, B., Passino, E., Sgobio, C., Bonsi, P., Barone, I., Ghiglieri, V., … Calabresi, P. (2006). Plastic and behavioral abnormalities in experimental Huntington’s disease: A crucial role for cholinergic interneurons. Neurobiology of Disease, 22(1), 143-152. doi:10.1016/j.nbd.2005.10.009 es_ES
dc.description.references Pisani, A., Bernardi, G., Ding, J., & Surmeier, D. J. (2007). Re-emergence of striatal cholinergic interneurons in movement disorders. Trends in Neurosciences, 30(10), 545-553. doi:10.1016/j.tins.2007.07.008 es_ES
dc.description.references Aosaki, T., Miura, M., Suzuki, T., Nishimura, K., & Masuda, M. (2010). Acetylcholine-dopamine balance hypothesis in the striatum: An update. Geriatrics & Gerontology International, 10, S148-S157. doi:10.1111/j.1447-0594.2010.00588.x es_ES
dc.description.references Connolly, B. S., & Lang, A. E. (2014). Pharmacological Treatment of Parkinson Disease. JAMA, 311(16), 1670. doi:10.1001/jama.2014.3654 es_ES
dc.description.references Levodopa and the Progression of Parkinson’s Disease. (2004). New England Journal of Medicine, 351(24), 2498-2508. doi:10.1056/nejmoa033447 es_ES
dc.description.references Jenner, P. (2002). Pharmacology of dopamine agonists in the treatment of Parkinson’s disease. Neurology, 58(Supplement 1), S1-S8. doi:10.1212/wnl.58.suppl_1.s1 es_ES
dc.description.references Stocchi, F. (1998). Dopamine Agonists in Parkinson???s Disease. CNS Drugs, 10(3), 159-170. doi:10.2165/00023210-199810030-00001 es_ES
dc.description.references Takahashi, S., Tohgi, H., Yonezawa, H., Obara, S., & Yamazaki, E. (1999). The effect of trihexyphenidyl, an anticholinergic agent, on regional cerebral blood flow and oxygen metabolism in patients with Parkinson’s disease. Journal of the Neurological Sciences, 167(1), 56-61. doi:10.1016/s0022-510x(99)00142-2 es_ES
dc.description.references Olanow, C. W., Agid, Y., & Mizuno, Y. (2005). Reply: Levodopa in the treatment of Parkinson’s disease: Current controversies. Movement Disorders, 20(5), 643-644. doi:10.1002/mds.20426 es_ES
dc.description.references Rascol, O., Payoux, P., Ory, F., Ferreira, J. J., Brefel-Courbon, C., & Montastruc, J.-L. (2003). Limitations of current Parkinson’s disease therapy. Annals of Neurology, 53(S3), S3-S15. doi:10.1002/ana.10513 es_ES
dc.description.references M�ller, T., Hefter, H., Hueber, R., Jost, W., Leenders, K., Odin, P., & Schwarz, J. (2004). Is levodopa toxic? Journal of Neurology, 251(S6). doi:10.1007/s00415-004-1610-x es_ES
dc.description.references Juliano, R. L., Sunnarborg, S., DeSimone, J., & Haroon, Z. (2011). Institutional Profile: The Carolina Center of Cancer Nanotechnology Excellence: past accomplishments and future perspectives. Nanomedicine, 6(1), 19-24. doi:10.2217/nnm.10.142 es_ES
dc.description.references López, T., Esquivel, D., Mendoza-Díaz, G., Ortiz-Islas, E., González, R. D., & Novaro, O. (2015). L-DOPA stabilization on sol–gel silica to be used as neurological nanoreservoirs: Structural and spectroscopic studies. Materials Letters, 161, 160-163. doi:10.1016/j.matlet.2015.08.015 es_ES
dc.description.references Aznar, E., Oroval, M., Pascual, L., Murguía, J. R., Martínez-Máñez, R., & Sancenón, F. (2016). Gated Materials for On-Command Release of Guest Molecules. Chemical Reviews, 116(2), 561-718. doi:10.1021/acs.chemrev.5b00456 es_ES
dc.description.references Giret, S., Wong Chi Man, M., & Carcel, C. (2015). Mesoporous‐Silica‐Functionalized Nanoparticles for Drug Delivery. Chemistry – A European Journal, 21(40), 13850-13865. doi:10.1002/chem.201500578 es_ES
dc.description.references Vallet-Regí, M., Balas, F., & Arcos, D. (2007). Mesoporous Materials for Drug Delivery. Angewandte Chemie International Edition, 46(40), 7548-7558. doi:10.1002/anie.200604488 es_ES
dc.description.references Vallet-Regí, M., Balas, F., & Arcos, D. (2007). Mesoporöse Materialien für den Wirkstofftransport. Angewandte Chemie, 119(40), 7692-7703. doi:10.1002/ange.200604488 es_ES
dc.description.references Kim, K. T., Meeuwissen, S. A., Nolte, R. J. M., & van Hest, J. C. M. (2010). Smart nanocontainers and nanoreactors. Nanoscale, 2(6), 844. doi:10.1039/b9nr00409b es_ES
dc.description.references Bao, G., Mitragotri, S., & Tong, S. (2013). Multifunctional Nanoparticles for Drug Delivery and Molecular Imaging. Annual Review of Biomedical Engineering, 15(1), 253-282. doi:10.1146/annurev-bioeng-071812-152409 es_ES
dc.description.references Mura, S., Nicolas, J., & Couvreur, P. (2013). Stimuli-responsive nanocarriers for drug delivery. Nature Materials, 12(11), 991-1003. doi:10.1038/nmat3776 es_ES
dc.description.references Wu, S.-H., Hung, Y., & Mou, C.-Y. (2011). Mesoporous silica nanoparticles as nanocarriers. Chemical Communications, 47(36), 9972. doi:10.1039/c1cc11760b es_ES
dc.description.references Tang, F., Li, L., & Chen, D. (2012). Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery. Advanced Materials, 24(12), 1504-1534. doi:10.1002/adma.201104763 es_ES
dc.description.references Li, Z., Barnes, J. C., Bosoy, A., Stoddart, J. F., & Zink, J. I. (2012). Mesoporous silica nanoparticles in biomedical applications. Chemical Society Reviews, 41(7), 2590. doi:10.1039/c1cs15246g es_ES
dc.description.references Tarn, D., Ashley, C. E., Xue, M., Carnes, E. C., Zink, J. I., & Brinker, C. J. (2013). Mesoporous Silica Nanoparticle Nanocarriers: Biofunctionality and Biocompatibility. Accounts of Chemical Research, 46(3), 792-801. doi:10.1021/ar3000986 es_ES
dc.description.references Zhao, Y., Vivero-Escoto, J. L., Slowing, I. I., Trewyn, B. G., & Lin, V. S.-Y. (2010). Capped mesoporous silica nanoparticles as stimuli-responsive controlled release systems for intracellular drug/gene delivery. Expert Opinion on Drug Delivery, 7(9), 1013-1029. doi:10.1517/17425247.2010.498816 es_ES
dc.description.references Argyo, C., Weiss, V., Bräuchle, C., & Bein, T. (2013). Multifunctional Mesoporous Silica Nanoparticles as a Universal Platform for Drug Delivery. Chemistry of Materials, 26(1), 435-451. doi:10.1021/cm402592t es_ES
dc.description.references Yang, Y.-W., Sun, Y.-L., & Song, N. (2014). Switchable Host–Guest Systems on Surfaces. Accounts of Chemical Research, 47(7), 1950-1960. doi:10.1021/ar500022f es_ES
dc.description.references Popat, A., Hartono, S. B., Stahr, F., Liu, J., Qiao, S. Z., & Qing (Max) Lu, G. (2011). Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation, and delivery carriers. Nanoscale, 3(7), 2801. doi:10.1039/c1nr10224a es_ES
dc.description.references Guardado-Alvarez, T. M., Sudha Devi, L., Russell, M. M., Schwartz, B. J., & Zink, J. I. (2013). Activation of Snap-Top Capped Mesoporous Silica Nanocontainers Using Two Near-Infrared Photons. Journal of the American Chemical Society, 135(38), 14000-14003. doi:10.1021/ja407331n es_ES
dc.description.references Sancenón, F., Pascual, L., Oroval, M., Aznar, E., & Martínez-Máñez, R. (2015). Gated Silica Mesoporous Materials in Sensing Applications. ChemistryOpen, 4(4), 418-437. doi:10.1002/open.201500053 es_ES
dc.description.references Yu, E., Galiana, I., Martínez-Máñez, R., Stroeve, P., Marcos, M. D., Aznar, E., … Amorós, P. (2015). Poly(N-isopropylacrylamide)-gated Fe3O4/SiO2 core shell nanoparticles with expanded mesoporous structures for the temperature triggered release of lysozyme. Colloids and Surfaces B: Biointerfaces, 135, 652-660. doi:10.1016/j.colsurfb.2015.06.048 es_ES
dc.description.references Baeza, A., Guisasola, E., Ruiz-Hernández, E., & Vallet-Regí, M. (2012). Magnetically Triggered Multidrug Release by Hybrid Mesoporous Silica Nanoparticles. Chemistry of Materials, 24(3), 517-524. doi:10.1021/cm203000u es_ES
dc.description.references Bernardos, A., Aznar, E., Marcos, M. D., Martínez-Máñez, R., Sancenón, F., Soto, J., … Amorós, P. (2009). Enzyme-Responsive Controlled Release Using Mesoporous Silica Supports Capped with Lactose. Angewandte Chemie International Edition, 48(32), 5884-5887. doi:10.1002/anie.200900880 es_ES
dc.description.references Bernardos, A., Aznar, E., Marcos, M. D., Martínez-Máñez, R., Sancenón, F., Soto, J., … Amorós, P. (2009). Enzyme-Responsive Controlled Release Using Mesoporous Silica Supports Capped with Lactose. Angewandte Chemie, 121(32), 5998-6001. doi:10.1002/ange.200900880 es_ES
dc.description.references Zhang, Z., Balogh, D., Wang, F., Sung, S. Y., Nechushtai, R., & Willner, I. (2013). Biocatalytic Release of an Anticancer Drug from Nucleic-Acids-Capped Mesoporous SiO2 Using DNA or Molecular Biomarkers as Triggering Stimuli. ACS Nano, 7(10), 8455-8468. doi:10.1021/nn403772j es_ES
dc.description.references El Sayed, S., Giménez, C., Aznar, E., Martínez-Máñez, R., Sancenón, F., & Licchelli, M. (2015). Highly selective and sensitive detection of glutathione using mesoporous silica nanoparticles capped with disulfide-containing oligo(ethylene glycol) chains. Organic & Biomolecular Chemistry, 13(4), 1017-1021. doi:10.1039/c4ob02083a es_ES
dc.description.references Bansal, A., & Zhang, Y. (2014). Photocontrolled Nanoparticle Delivery Systems for Biomedical Applications. Accounts of Chemical Research, 47(10), 3052-3060. doi:10.1021/ar500217w es_ES
dc.description.references Ozalp, V. C., Eyidogan, F., & Oktem, H. A. (2011). Aptamer-Gated Nanoparticles for Smart Drug Delivery. Pharmaceuticals, 4(8), 1137-1157. doi:10.3390/ph4081137 es_ES
dc.description.references De la Rica, R., Aili, D., & Stevens, M. M. (2012). Enzyme-responsive nanoparticles for drug release and diagnostics. Advanced Drug Delivery Reviews, 64(11), 967-978. doi:10.1016/j.addr.2012.01.002 es_ES
dc.description.references Leung, K. C.-F., Chak, C.-P., Lo, C.-M., Wong, W.-Y., Xuan, S., & Cheng, C. H. K. (2009). pH-Controllable Supramolecular Systems. Chemistry - An Asian Journal, 4(3), 364-381. doi:10.1002/asia.200800320 es_ES
dc.description.references Villalonga, R., Díez, P., Sánchez, A., Aznar, E., Martínez-Máñez, R., & Pingarrón, J. M. (2013). Enzyme-Controlled Sensing-Actuating Nanomachine Based on Janus Au-Mesoporous Silica Nanoparticles. Chemistry - A European Journal, 19(24), 7889-7894. doi:10.1002/chem.201300723 es_ES
dc.description.references Díez, P., Sánchez, A., Gamella, M., Martínez-Ruíz, P., Aznar, E., de la Torre, C., … Pingarrón, J. M. (2014). Toward the Design of Smart Delivery Systems Controlled by Integrated Enzyme-Based Biocomputing Ensembles. Journal of the American Chemical Society, 136(25), 9116-9123. doi:10.1021/ja503578b es_ES
dc.description.references Coll, C., Bernardos, A., Martínez-Máñez, R., & Sancenón, F. (2012). Gated Silica Mesoporous Supports for Controlled Release and Signaling Applications. Accounts of Chemical Research, 46(2), 339-349. doi:10.1021/ar3001469 es_ES
dc.description.references Aznar, E., Martínez-Máñez, R., & Sancenón, F. (2009). Controlled release using mesoporous materials containing gate-like scaffoldings. Expert Opinion on Drug Delivery, 6(6), 643-655. doi:10.1517/17425240902895980 es_ES
dc.description.references Ultimo, A., Giménez, C., Bartovsky, P., Aznar, E., Sancenón, F., Marcos, M. D., … Murguía, J. R. (2016). Targeting Innate Immunity with dsRNA-Conjugated Mesoporous Silica Nanoparticles Promotes Antitumor Effects on Breast Cancer Cells. Chemistry - A European Journal, 22(5), 1582-1586. doi:10.1002/chem.201504629 es_ES
dc.description.references Pascual, L., Baroja, I., Aznar, E., Sancenón, F., Marcos, M. D., Murguía, J. R., … Martínez-Máñez, R. (2015). Oligonucleotide-capped mesoporous silica nanoparticles as DNA-responsive dye delivery systems for genomic DNA detection. Chemical Communications, 51(8), 1414-1416. doi:10.1039/c4cc08306g es_ES
dc.description.references Giménez, C., Climent, E., Aznar, E., Martínez-Máñez, R., Sancenón, F., Marcos, M. D., … Rurack, K. (2014). Über den chemischen Informationsaustausch zwischen gesteuerten Nanopartikeln. Angewandte Chemie, 126(46), 12838-12843. doi:10.1002/ange.201405580 es_ES
dc.description.references Meng, H., Xue, M., Xia, T., Zhao, Y.-L., Tamanoi, F., Stoddart, J. F., … Nel, A. E. (2010). Autonomous in Vitro Anticancer Drug Release from Mesoporous Silica Nanoparticles by pH-Sensitive Nanovalves. Journal of the American Chemical Society, 132(36), 12690-12697. doi:10.1021/ja104501a es_ES
dc.description.references Xue, M., Zhong, X., Shaposhnik, Z., Qu, Y., Tamanoi, F., Duan, X., & Zink, J. I. (2011). pH-Operated Mechanized Porous Silicon Nanoparticles. Journal of the American Chemical Society, 133(23), 8798-8801. doi:10.1021/ja201252e es_ES
dc.description.references Wang, T., Wang, M., Ding, C., & Fu, J. (2014). Mono-benzimidazole functionalized β-cyclodextrins as supramolecular nanovalves for pH-triggered release of p-coumaric acid. Chem. Commun., 50(83), 12469-12472. doi:10.1039/c4cc05677a es_ES
dc.description.references Angelos, S., Khashab, N. M., Yang, Y.-W., Trabolsi, A., Khatib, H. A., Stoddart, J. F., & Zink, J. I. (2009). pH Clock-Operated Mechanized Nanoparticles. Journal of the American Chemical Society, 131(36), 12912-12914. doi:10.1021/ja9010157 es_ES
dc.description.references Turkevich, J., Stevenson, P. C., & Hillier, J. (1951). A study of the nucleation and growth processes in the synthesis of colloidal gold. Discussions of the Faraday Society, 11, 55. doi:10.1039/df9511100055 es_ES
dc.description.references Gómez, L., Ramírez, H. L., Villalonga, M. L., Hernández, J., & Villalonga, R. (2006). Immobilization of chitosan-modified invertase on alginate-coated chitin support via polyelectrolyte complex formation. Enzyme and Microbial Technology, 38(1-2), 22-27. doi:10.1016/j.enzmictec.2004.10.008 es_ES
dc.description.references Chico, B., Camacho, C., Pérez, M., Longo, M. A., Sanromán, M. A., Pingarrón, J. M., & Villalonga, R. (2009). Polyelectrostatic immobilization of gold nanoparticles-modified peroxidase on alginate-coated gold electrode for mediatorless biosensor construction. Journal of Electroanalytical Chemistry, 629(1-2), 126-132. doi:10.1016/j.jelechem.2009.02.004 es_ES
dc.description.references Sánchez, A., Díez, P., Martínez-Ruíz, P., Villalonga, R., & Pingarrón, J. M. (2013). Janus Au-mesoporous silica nanoparticles as electrochemical biorecognition-signaling system. Electrochemistry Communications, 30, 51-54. doi:10.1016/j.elecom.2013.02.008 es_ES
dc.description.references Jerez, G., Kaufman, G., Prystai, M., Schenkeveld, S., & Donkor, K. K. (2009). Determination of thermodynamic pKavalues of benzimidazole and benzimidazole derivatives by capillary electrophoresis. Journal of Separation Science, 32(7), 1087-1095. doi:10.1002/jssc.200800482 es_ES
dc.description.references Lin, S., Liu, C.-C., & Chou, T.-C. (2004). Amperometric acetylcholine sensor catalyzed by nickel anode electrode. Biosensors and Bioelectronics, 20(1), 9-14. doi:10.1016/j.bios.2004.01.018 es_ES
dc.description.references Vizi, E., Fekete, A., Karoly, R., & Mike, A. (2010). Non-synaptic receptors and transporters involved in brain functions and targets of drug treatment. British Journal of Pharmacology, 160(4), 785-809. doi:10.1111/j.1476-5381.2009.00624.x es_ES
dc.description.references Schena, A., & Johnsson, K. (2013). Sensing Acetylcholine and Anticholinesterase Compounds. Angewandte Chemie International Edition, 53(5), 1302-1305. doi:10.1002/anie.201307754 es_ES
dc.description.references Schena, A., & Johnsson, K. (2014). Sensing Acetylcholine and Anticholinesterase Compounds. Angewandte Chemie, 126(5), 1326-1329. doi:10.1002/ange.201307754 es_ES
dc.description.references Zhou, Y., Tan, L.-L., Li, Q.-L., Qiu, X.-L., Qi, A.-D., Tao, Y., & Yang, Y.-W. (2014). Acetylcholine-Triggered Cargo Release from Supramolecular Nanovalves Based on Different Macrocyclic Receptors. Chemistry - A European Journal, 20(11), 2998-3004. doi:10.1002/chem.201304864 es_ES
dc.description.references Hassler, R., Haug, P., Nitsch, C., Kim, J. S., & Paik, K. (1982). Effect of Motor and Premotor Cortex Ablation on Concentrations of Amino Acids, Monoamines, and Acetylcholine and on the Ultrastructure in Rat Striatum. A Confirmation of Glutamate as the Specific Cortico-Striatal Transmitter. Journal of Neurochemistry, 38(4), 1087-1098. doi:10.1111/j.1471-4159.1982.tb05352.x es_ES
dc.description.references SETHY, V. H., & WOERT, M. H. V. (1974). Regulation of striatal acetylcholine concentration by dopamine receptors. Nature, 251(5475), 529-530. doi:10.1038/251529a0 es_ES
dc.description.references Batool, Z., Sadir, S., Liaquat, L., Tabassum, S., Madiha, S., Rafiq, S., … Haider, S. (2016). Repeated administration of almonds increases brain acetylcholine levels and enhances memory function in healthy rats while attenuates memory deficits in animal model of amnesia. Brain Research Bulletin, 120, 63-74. doi:10.1016/j.brainresbull.2015.11.001 es_ES


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