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Mechanical unfolding of long human telomeric RNA (TERRA)

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Mechanical unfolding of long human telomeric RNA (TERRA)

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dc.contributor.author Garavís, M. es_ES
dc.contributor.author Bocanegra, R. es_ES
dc.contributor.author Herrero-Galán, E. es_ES
dc.contributor.author González, C. es_ES
dc.contributor.author Villasante, A. es_ES
dc.contributor.author Arias-Gonzalez, J. R. es_ES
dc.date.accessioned 2020-10-21T03:31:19Z
dc.date.available 2020-10-21T03:31:19Z
dc.date.issued 2013 es_ES
dc.identifier.issn 1359-7345 es_ES
dc.identifier.uri http://hdl.handle.net/10251/152715
dc.description.abstract [EN] We report the first single molecule investigation of TERRA molecules. By using optical-tweezers and other biophysical techniques, we have found that long RNA constructions of up to 25 GGGUUA repeats form higher order structures comprised of single parallel G-quadruplex blocks, which unfold at lower forces than their DNA counterparts. es_ES
dc.description.sponsorship This work was supported by grants from the Spanish Ministry of Science and Innovation (grants RYC2007-01765 to JRA-G, BFU2011-30295-C02-01 to AV, and CTQ2010-21567-C02-02 to CG). MG was supported by the FPI fellowship BES-2009-027909. RB and EH-G were supported by Comunidad de Madrid, grant CAM-S2009MAT-1507. AV acknowledges an institutional grant from the Fundacion Ramon Areces to the CBMSO. JRA-G wants to thank Prof. J. L. Carrascosa and Prof. J. M. Valpuesta (CNB-CSIC) for their continuous support and encouragement in this research. We also acknowledge the excellent technical assistance of Beatriz de Pablos (CBMSO). es_ES
dc.language Inglés es_ES
dc.publisher The Royal Society of Chemistry es_ES
dc.relation MICINN/RYC-2007-01765 es_ES
dc.relation CAM/S2009/MAT/1507 es_ES
dc.relation MICINN/BFU2011-30295-C02-01 es_ES
dc.relation MICINN/CTQ2010-21567-C02-02 es_ES
dc.relation MICINN/BES-2009-027909 es_ES
dc.relation.ispartof Chemical Communications es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject G-quadruplex es_ES
dc.subject TERRA es_ES
dc.subject Single-molecule es_ES
dc.subject Optical tweezers es_ES
dc.subject Unfolding es_ES
dc.subject Stability es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Mechanical unfolding of long human telomeric RNA (TERRA) es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1039/c3cc42981d es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.description.bibliographicCitation Garavís, M.; Bocanegra, R.; Herrero-Galán, E.; González, C.; Villasante, A.; Arias-Gonzalez, JR. (2013). Mechanical unfolding of long human telomeric RNA (TERRA). Chemical Communications. 49(57):6397-6399. https://doi.org/10.1039/c3cc42981d es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1039/c3cc42981d es_ES
dc.description.upvformatpinicio 6397 es_ES
dc.description.upvformatpfin 6399 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 49 es_ES
dc.description.issue 57 es_ES
dc.identifier.pmid 23748212 es_ES
dc.relation.pasarela 408020 es_ES
dc.contributor.funder Comunidad de Madrid es_ES
dc.contributor.funder Fundación Ramón Areces es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
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