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Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase

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Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase

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Morin, J.; Cao, F.; Lázaro, J.; Arias-Gonzalez, JR.; Valpuesta, J.; Carrascosa, J.; Salas, M.... (2015). Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase. Nucleic Acids Research. 43(7):3643-3652. https://doi.org/10.1093/nar/gkv204

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Título: Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase
Autor: Morin, J.A. Cao, F.J. Lázaro, J.M. Arias-Gonzalez, J. R. Valpuesta, J.M. Carrascosa, J.L. Salas, M. Ibarra, B.
Entidad UPV: Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada
Fecha difusión:
Resumen:
[EN] During DNA replication replicative polymerases move in discrete mechanical steps along the DNA template. To address how the chemical cycle is coupled to mechanical motion of the enzyme, here we use optical tweezers ...[+]
Palabras clave: DNA replication , DNA polymerase , Single-molecule , Mechano-chemistry
Derechos de uso: Reconocimiento (by)
Fuente:
Nucleic Acids Research. (issn: 0305-1048 )
DOI: 10.1093/nar/gkv204
Editorial:
Oxford University Press
Versión del editor: https://doi.org/10.1093/nar/gkv204
Código del Proyecto:
info:eu-repo/grantAgreement/MICINN//BFU2011-29038-C02-02/ES/ANALISIS ESTRUCTURAL INTEGRADO A DISTINTOS NIVELES DE RESOLUCION: ESTUDIO DE SISTEMAS VIRALES MODELO/
...[+]
info:eu-repo/grantAgreement/MICINN//BFU2011-29038-C02-02/ES/ANALISIS ESTRUCTURAL INTEGRADO A DISTINTOS NIVELES DE RESOLUCION: ESTUDIO DE SISTEMAS VIRALES MODELO/
info:eu-repo/grantAgreement/MINECO//BFU2013-44202-P/ES/CHAPERONAS MOLECULARES: UNA CADENA DE MONTAJE DE MAQUINAS MOLECULARES INVOLUCRADA EN EL PLEGAMIENTO Y DEGRADACION DE PROTEINAS/
info:eu-repo/grantAgreement/MICINN//BFU2011-23645/ES/REPLICACION DEL DNA DE Ø29 INICIADA CON PROTEINA TERMINAL/
info:eu-repo/grantAgreement/MICINN//FIS2010-17440/ES/FISICA DE LOS PROCESOS FUERA DEL EQUILIBRIO: RETROALIMENTACION, ENTROPIA E INFORMACION/
info:eu-repo/grantAgreement/MINECO//GR35%2F10-A920/
info:eu-repo/grantAgreement/MINECO//GR35%2F10-A911/
info:eu-repo/grantAgreement/MINECO//MAT2013-49455-EXP/ES/G-CUADRUPLEX COMO INTERRUPTOR MOLECULAR CONTROLADO POR NANOPARTICULAS Y DEMOSTRADO POR PINZAS OPTICAS/
info:eu-repo/grantAgreement/MINECO//BFU2012-31825/ES/DINAMICA DE LA REPLICACION DEL ADN MITOCONDRIAL A NIVEL DE MOLECULAS INDIVIDUALES./
info:eu-repo/grantAgreement/MEC//CSD2007-00015/ES/INESTABILIDAD GENOMICA/
info:eu-repo/grantAgreement/EMBO//ASTF 276-2012/
info:eu-repo/grantAgreement/Gobierno de la Comunidad de Madrid//S2009%2FMAT-1507/ES/Nuevos materiales y dispositivos biofuncionales híbridos en nanociencia/
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Agradecimientos:
We thank Stephan Grill laboratory (MPI-CBG, Dresden) for help with data collection and E. Galburt, M. Manosas and M. De Vega for critical reading of the manuscript. Spanish Ministry of Economy and Competitiveness [BFU2011-29038 ...[+]
Tipo: Artículo

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