Revert, A.; Calm, R.; Vehí, J.; Bondía Company, J. (2011). Calculation of the Best Basal-Bolus Combination for Postprandial Glucose Control in Insulin Pump Therapy. IEEE Transactions on Biomedical Engineering. 58(2):274-281. https://doi.org/10.1109/TBME.2010.2058805
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/153040
Título:
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Calculation of the Best Basal-Bolus Combination for Postprandial Glucose Control in Insulin Pump Therapy
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Autor:
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Revert, Ana
Calm, Remei
Vehí, Josep
Bondía Company, Jorge
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Entidad UPV:
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Universitat Politècnica de València. Departamento de Ingeniería de Sistemas y Automática - Departament d'Enginyeria de Sistemes i Automàtica
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Fecha difusión:
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Resumen:
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[EN] Intensive insulin therapy in type 1 diabetes is based on the well-established practice of adjusting basal and bolus insulin independently. Basal insulin delivery is designed to optimize glucose concentrations between ...[+]
[EN] Intensive insulin therapy in type 1 diabetes is based on the well-established practice of adjusting basal and bolus insulin independently. Basal insulin delivery is designed to optimize glucose concentrations between meals and overnight, while bolus insulin delivery is designed to optimize postprandial glucose concentrations. However, this strategy shows some limitations in the postprandial glucose control, especially for meals with high carbohydrate content. Strategies based on coordinating basal and bolus insulin in the postprandial period help in overcoming these limitations. An algorithm, based on mathematically guaranteed techniques (interval analysis), is presented in this paper. It determines, given the current glycemic state of the patient and the meal to be ingested, a basal-bolus combination that will yield a tight postprandial glycemic control according to the International Diabetes Federation guidelines. For a given meal, the algorithm reveals which bolus administration mode will enable a good postprandial performance: standard, square-wave, dual-wave, or temporal basal decrement. The algorithm is validated through an in silico study using the 30 subjects in the educational version of the Food and Drug Administration accepted University of Virginia simulator.
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Palabras clave:
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Insulin pump therapy
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Interval analysis
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Optimal experiment design (OED)
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Postprandial glucose control
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Set inversion
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Type 1 diabetes
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Derechos de uso:
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Reserva de todos los derechos
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Fuente:
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IEEE Transactions on Biomedical Engineering. (issn:
0018-9294
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DOI:
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10.1109/TBME.2010.2058805
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Editorial:
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Institute of Electrical and Electronics Engineers
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Versión del editor:
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https://doi.org/10.1109/TBME.2010.2058805
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Código del Proyecto:
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info:eu-repo/grantAgreement/Generalitat de Catalunya//2005SGR 00296/ES/Automation engineering and distributed systems - Ajuts per a grups de recerca consolidats (GRC)/
info:eu-repo/grantAgreement/UPV//PAID-05-08/
info:eu-repo/grantAgreement/MEC//DPI2007-66728-C02-01/ES/CONTROL DE GLUCEMIA EN LAZO CERRADO EN PACIENTES CON DIABETES MELLITUS 1 Y PACIENTES CRITICOS/
info:eu-repo/grantAgreement/MICINN//DPI2010-20764-C02-01/ES/NUEVAS ESTRATEGIAS DE CONTROL GLUCEMICO POSTPRANDIAL MEDIANTE TERAPIA CON BOMBA DE INSULINA EN DIABETES TIPO 1/
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Descripción:
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"© 2011 IEEE. Personal use of this material is permitted. Permissíon from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertisíng or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works."
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Agradecimientos:
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This work was supported by the Spanish Government under Grants DPI-2007-66728 and DPI-2010-20764-C02, by the FEDER funds from European Union, by the Generalitat de Catalunya under Grant SGR-00296, and by the PAID-05-08 ...[+]
This work was supported by the Spanish Government under Grants DPI-2007-66728 and DPI-2010-20764-C02, by the FEDER funds from European Union, by the Generalitat de Catalunya under Grant SGR-00296, and by the PAID-05-08 program of the Universidad Politecnica de Valencia.
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Tipo:
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Artículo
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