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Biocompatibility and internalization assessment of bare and functionalised mesoporous silica nanoparticles

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Biocompatibility and internalization assessment of bare and functionalised mesoporous silica nanoparticles

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Nombre: Garrido-Cano;Cand ...
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dc.contributor.author Garrido-Cano, Iris es_ES
dc.contributor.author Candela-Noguera, Vicente es_ES
dc.contributor.author Herrera, Guadalupe es_ES
dc.contributor.author Cejalvo, Juan Miguel es_ES
dc.contributor.author Lluch, Ana es_ES
dc.contributor.author Marcos Martínez, María Dolores es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.contributor.author Eroles, Pilar es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.date.accessioned 2021-03-26T04:31:11Z
dc.date.available 2021-03-26T04:31:11Z
dc.date.issued 2021-01 es_ES
dc.identifier.issn 1387-1811 es_ES
dc.identifier.uri http://hdl.handle.net/10251/164422
dc.description.abstract [EN] We report herein an evaluation of the effect of several mesoporous silica nanoparticles (MSNs) on the cellular uptake and in vitro cytotoxicity in human cells. Bare MSNs and MSNs functionalized with polyethylene glycol or hyaluronic acid are employed to evaluate uptake efficiency and mechanisms of endocytosis in cancer (MDA-MB-231) and non-cancer (MCF10A) cells. Moreover, changes in viability, cell cycle, oxidative stress, and mitochondrial membrane potential are evaluated. Our results confirm that MSNs are internalized efficiently by human cells and that uptake mechanisms differ for cell types and particles. We also confirm that MSNs are biocompatible materials that do not induce ROS/RNS production, nor changes on mitochondrial membrane potential or cell cycle. es_ES
dc.description.sponsorship The authors want to thank the Spanish Government RTI2018-100910-B-C41 (MCUI/AEI/FEDER, UE) and PI18/01219 (ISCIII), the Generalitat Valenciana (PROMETEO/2018/024 and ACIF/2016/030), and CIBER-BBN (CB07/01/2012) and CIBER-ONC (CB16/12/00481) for support. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Microporous and Mesoporous Materials es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Mesoporous silica nanoparticles es_ES
dc.subject Internalization es_ES
dc.subject Toxicity es_ES
dc.subject Biocompatibility es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.subject.classification BIOQUIMICA Y BIOLOGIA MOLECULAR es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.title Biocompatibility and internalization assessment of bare and functionalised mesoporous silica nanoparticles es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.micromeso.2020.110593 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//PI18%2F01219/ES/Caracterización y repercusión terapéutica de la ecología de cáncer de mama HER2 positivo/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//AICO%2F2016%2F030/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//CB07%2F01%2F2012/ES/Bioingeniería, biomateriales y nanomedicina/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CB16%2F12%2F00481/ES/CANCER/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2018%2F024/ES/Sistemas avanzados de liberación controlada/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-100910-B-C41/ES/MATERIALES POROSOS INTELIGENTES MULTIFUNCIONALES Y DISPOSITIVOS ELECTRONICOS PARA LA LIBERACION DE FARMACOS, DETECCION DE DROGAS Y BIOMARCADORES Y COMUNICACION A NANOESCALA/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Garrido-Cano, I.; Candela-Noguera, V.; Herrera, G.; Cejalvo, JM.; Lluch, A.; Marcos Martínez, MD.; Sancenón Galarza, F.... (2021). Biocompatibility and internalization assessment of bare and functionalised mesoporous silica nanoparticles. Microporous and Mesoporous Materials. 310:1-12. https://doi.org/10.1016/j.micromeso.2020.110593 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.micromeso.2020.110593 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 12 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 310 es_ES
dc.relation.pasarela S\423349 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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