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Carnosic acid-rich rosemary (Rosmarinus officinalis L.) leaf extract limits weight gain and improves cholesterol levels and glycaemia in mice on a high-fat diet

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Carnosic acid-rich rosemary (Rosmarinus officinalis L.) leaf extract limits weight gain and improves cholesterol levels and glycaemia in mice on a high-fat diet

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dc.contributor.author Ibarra, Alvin es_ES
dc.contributor.author Cases, Julien es_ES
dc.contributor.author Roller, Marc es_ES
dc.contributor.author Chiralt, A. es_ES
dc.contributor.author Coussaert, Aurélie Coussaert es_ES
dc.contributor.author Ripoll, Christophe
dc.date.accessioned 2013-04-16T11:14:56Z
dc.date.available 2013-04-16T11:14:56Z
dc.date.issued 2011
dc.identifier.issn 0007-1145
dc.identifier.uri http://hdl.handle.net/10251/27906
dc.description.abstract Rosemary (Rosmarinus officinalis L.) extracts (RE) are natural antioxidants that are used in food, food supplements and cosmetic applications; exert anti-inflammatory and anti-hyperglycaemic effects; and promote weight loss, which can be exploited to develop new preventive strategies against metabolic disorders. Therefore, the aim of the present study was to evaluate the preventive effects of rosemary leaf extract that was standardised to 20 % carnosic acid (RE) on weight gain, glucose levels and lipid homeostasis in mice that had begun a high-fat diet (HFD) as juveniles. The animals were given a low-fat diet, a HFD or a HFD that was supplemented with 500 mg RE/kg body weight per d (mpk). Physiological and biochemical parameters were monitored for 16 weeks. Body and epididymal fat weight in animals on the HFD that was supplemented with RE increased 69 and 79 % less than those in the HFD group. Treatment with RE was associated with increased faecal fat excretion but not with decreased food intake. The extract also reduced fasting glycaemia and plasma cholesterol levels. In addition, we evaluated the inhibitory effects of RE in vitro on pancreatic lipase and PPAR-¿ agonist activity; the in vitro findings correlated with our observations in the animal experiments. Thus, the present results suggest that RE that is rich in carnosic acid can be used as a preventive treatment against metabolic disorders, which merits further examination at physiological doses in randomised controlled trials. © Copyright © The Authors 2011. es_ES
dc.description.sponsorship Naturex is involved in the research/development and marketing/sales of rosemary extracts as ingredients for the food, cosmetic and nutraceutical industries. Therefore, Naturex has a commercial interest in this publication. Naturalpha was paid by Naturex to perform and report the scientific work that formed the basis of this publication. Naturalpha and Naturex declare that the data in this report represent a true and faithful representation of the work that has been performed. The financial assistance from Naturex is gratefully acknowledged. A. I. and C. R. designed the protocol. J. C. and M. R. developed the sample of RE. The study was conducted under the supervision of A. C. A. C.-B. analysed the data and reviewed the manuscript. en_EN
dc.format.extent 8 es_ES
dc.language Español es_ES
dc.publisher Cambridge University Press es_ES
dc.relation.ispartof British Journal of Nutrition es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Carnosic acid es_ES
dc.subject Pancreatic lipase es_ES
dc.subject PPAR-¿ es_ES
dc.subject Rosmarinus officinalis L. es_ES
dc.subject Cholesterol es_ES
dc.subject Fatty acid es_ES
dc.subject Glucose es_ES
dc.subject Insulin es_ES
dc.subject Peroxisome proliferator activated receptor gamma es_ES
dc.subject Rosiglitazone es_ES
dc.subject Rosmarinus officinalis extract es_ES
dc.subject Triacylglycerol es_ES
dc.subject Triacylglycerol lipase es_ES
dc.subject Animal cell es_ES
dc.subject Animal experiment es_ES
dc.subject Article es_ES
dc.subject Body weight es_ES
dc.subject Caloric intake es_ES
dc.subject Cholesterol blood level es_ES
dc.subject Chronic drug administration es_ES
dc.subject Controlled study es_ES
dc.subject Epididymis fat es_ES
dc.subject Epididymis fat weight es_ES
dc.subject Experimental model es_ES
dc.subject Fatty acid blood level es_ES
dc.subject Fecal fat excretion es_ES
dc.subject Feces analysis es_ES
dc.subject Food intake es_ES
dc.subject Glucose blood level es_ES
dc.subject In vitro study es_ES
dc.subject Insulin blood level es_ES
dc.subject Juvenile animal es_ES
dc.subject Lipid diet es_ES
dc.subject Liver weight es_ES
dc.subject Low fat diet es_ES
dc.subject Male es_ES
dc.subject Mouse es_ES
dc.subject Nonhuman es_ES
dc.subject Plant leaf es_ES
dc.subject Triacylglycerol blood level es_ES
dc.subject Weight gain es_ES
dc.subject Animals es_ES
dc.subject Antioxidants es_ES
dc.subject Blood Glucose es_ES
dc.subject Diet, High-Fat es_ES
dc.subject Diterpenes, Abietane es_ES
dc.subject Eating es_ES
dc.subject Metabolic Diseases es_ES
dc.subject Mice es_ES
dc.subject Mice, Inbred C3H es_ES
dc.subject Organ Size es_ES
dc.subject Phytotherapy es_ES
dc.subject Plant Extracts es_ES
dc.subject Plant Leaves es_ES
dc.subject Rosmarinus es_ES
dc.subject Animalia es_ES
dc.subject Mus es_ES
dc.subject Rosmarinus officinalis es_ES
dc.subject.classification TECNOLOGIA DE ALIMENTOS es_ES
dc.title Carnosic acid-rich rosemary (Rosmarinus officinalis L.) leaf extract limits weight gain and improves cholesterol levels and glycaemia in mice on a high-fat diet es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1017/S0007114511001620
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Tecnología de Alimentos - Departament de Tecnologia d'Aliments es_ES
dc.description.bibliographicCitation Ibarra, A.; Cases, J.; Roller, M.; Chiralt Boix, MA.; Coussaert, AC.; Ripoll, C. (2011). Carnosic acid-rich rosemary (Rosmarinus officinalis L.) leaf extract limits weight gain and improves cholesterol levels and glycaemia in mice on a high-fat diet. British Journal of Nutrition. 106(8):1-8. doi:10.1017/S0007114511001620 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8411563 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 8 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 106 es_ES
dc.description.issue 8 es_ES
dc.relation.senia 41461
dc.contributor.funder Naturex
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