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dc.contributor.author | Roca Marugán, Marta Isabel | es_ES |
dc.contributor.author | Villegas, L. | es_ES |
dc.contributor.author | Kortabitarte, M.L. | es_ES |
dc.contributor.author | Althaus R. L. | es_ES |
dc.contributor.author | Molina Pons, Mª Pilar | es_ES |
dc.date.accessioned | 2015-05-27T12:33:38Z | |
dc.date.available | 2015-05-27T12:33:38Z | |
dc.date.issued | 2011-11 | |
dc.identifier.issn | 0022-0302 | |
dc.identifier.uri | http://hdl.handle.net/10251/50869 | |
dc.description.abstract | The presence of residues of antimicrobial substances in milk may have serious toxicological and technical consequences. To date, few studies have been done to evaluate the effect of heat treatments on β-lactam residues in milk. However, the few studies that have been conducted estimate losses of antimicrobial activity under different combinations of temperature and time using microbiological methods. The aims of this study were to calculate the kinetic parameters for the degradation of β-lactam antibiotics in milk and to develop prediction models to estimate the concentration losses of these compounds in conventional dairy heat treatments. To do so, we employed a quantitative HPLC method to calculate losses in concentrations of 10 β-lactam antibiotics in milk with different combinations of temperature and time. Increasing the temperature from 60°C to 100°C decreased the half-life of amoxicillin (372 to 50 min), ampicillin (741 to 26 min), cloxacillin (367 to 46 min), and penicillin G (382 to 43 min). These increases in temperature caused further degradation in cephalosporins, which was accompanied by a decrease in half-life times to reach very low values; for instance, 4, 5, and 6 min for cefoperazone, cephurexime, and cephapirin, respectively. Kinetic equations were applied to different heat treatments used in dairy processing. Heat treatments at high temperatures and long times (e.g., 120ºC for 20 min) led to a further degradation of β-lactam antibiotics with percentages close to 100% for cefoperazone and cefuroxime. In contrast, when milk was subjected to heat treatments at lower temperatures and times (e.g., 72°C for 15 s), the degradation of β-lactam in milk did not exceed 1% for the 10 antibiotics tested. | es_ES |
dc.description.sponsorship | This work is part of the AGL2003-03663 project financed by the Spanish Ministry of Education and Science (Madrid, Spain) and the Vice-Rectorate for Research, Development and Innovation of the Polytechnic University of Valencia (UPV), Spain. The authors thank the UPV for funding the collaboration of Rafael Althaus. | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | American Dairy Science Association | es_ES |
dc.relation.ispartof | Journal of Dairy Science | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Antibiotics | es_ES |
dc.subject | Milk | es_ES |
dc.subject | β-lactams | es_ES |
dc.subject | Thermostability | es_ES |
dc.subject.classification | PRODUCCION ANIMAL | es_ES |
dc.title | Effect of heat tratments on stability on b-lactams in milk | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.3168/jds.2010-3599 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MICYT//AGL2003-03663/ES/EFECTO DE LOS TRATAMIENTOS TERMICOS SOBRE LA ACTIVIDAD Y%2FO PRESENCIA DE SUSTANCIAS ANTIMICROBIANAS EN LA LECHE/ | es_ES |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal | es_ES |
dc.description.bibliographicCitation | Roca Marugán, MI.; Villegas, L.; Kortabitarte, M.; Althaus R. L.; Molina Pons, MP. (2011). Effect of heat tratments on stability on b-lactams in milk. Journal of Dairy Science. 94(3):1155-1164. https://doi.org/10.3168/jds.2010-3599 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://dx.doi.org/ 10.3168/jds.2010-3599 | es_ES |
dc.description.upvformatpinicio | 1155 | es_ES |
dc.description.upvformatpfin | 1164 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 94 | es_ES |
dc.description.issue | 3 | es_ES |
dc.relation.senia | 40913 | |
dc.identifier.eissn | 1525-3198 | |
dc.contributor.funder | Ministerio de Ciencia y Tecnología | es_ES |