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Chemometric approaches to improve PLSDA model outcome for predicting human non-alcoholic fatty liver disease using UPLC-MS as a metabolic profiling tool

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Chemometric approaches to improve PLSDA model outcome for predicting human non-alcoholic fatty liver disease using UPLC-MS as a metabolic profiling tool

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Quintás, G.; Portillo Poblador, N.; García Cañaveras, JC.; Castell, JV.; Ferrer, A.; Lahoz, A. (2012). Chemometric approaches to improve PLSDA model outcome for predicting human non-alcoholic fatty liver disease using UPLC-MS as a metabolic profiling tool. Metabolomics. 8(1):86-98. https://doi.org/10.1007/s11306-011-0292-5

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/62036

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Título: Chemometric approaches to improve PLSDA model outcome for predicting human non-alcoholic fatty liver disease using UPLC-MS as a metabolic profiling tool
Autor: Quintás, Guillermo Portillo Poblador, Nuria García Cañaveras, Juan Carlos Castell, José Vicente Ferrer, Alberto Lahoz, Agustín
Entidad UPV: Universitat Politècnica de València. Departamento de Estadística e Investigación Operativa Aplicadas y Calidad - Departament d'Estadística i Investigació Operativa Aplicades i Qualitat
Fecha difusión:
Resumen:
An MS-based metabolomics strategy including variable selection and PLSDA analysis has been assessed as a tool to discriminate between non-steatotic and steatotic human liver profiles. Different chemometric approaches for ...[+]
Palabras clave: Mass spectrometry , Metabolomics , PLSDA and steatosis , Bile acid , Biological marker , Glutathione , Lysophospholipid , Accuracy , Adult , Article , Chemometric analysis , Computer program , Controlled study , Discriminant analysis , Disease marker , External validity , Female , Human , Human tissue , Male , Metabolite , Nonalcoholic fatty liver , Partial least squares discriminant analysis , Principal component analysis , Reproducibility , Signal noise ratio , Standardization , Time of flight mass spectrometry , Ultra performance liquid chromatography , Validation process
Derechos de uso: Cerrado
Fuente:
Metabolomics. (issn: 1573-3882 ) (eissn: 1573-3890 )
DOI: 10.1007/s11306-011-0292-5
Editorial:
Springer Verlag (Germany)
Versión del editor: http://dx.doi.org/10.1007/s11306-011-0292-5
Código del Proyecto:
info:eu-repo/grantAgreement/GVA//AP-193%2F10/
info:eu-repo/grantAgreement/MICINN//CP08%2F00125/ES/CP08%2F00125/
Descripción: The online version of this article (doi:10.​1007/​s11306-011-0292-5) contains supplementary material, which is available to authorized users.
Agradecimientos:
This work has been supported by Conselleria de Sanitat (Regional Valencian Ministry of Health) contract (AP-193/10). A. L is grateful for a Miguel Servet contract (CP08/00125) from the Spanish Ministry of Science and ...[+]
Tipo: Artículo

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