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In silico assessment of drug safety in human heart applied to late sodium current blockers

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In silico assessment of drug safety in human heart applied to late sodium current blockers

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Trénor Gomis, BA.; Gomis-Tena Dolz, J.; Cardona Urrego, KE.; Romero Pérez, L.; Rajamani, S.; Belardinelli, L.; Giles, WR.... (2013). In silico assessment of drug safety in human heart applied to late sodium current blockers. Channels. 7(4):1-14. https://doi.org/10.4161/chan.24905

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/67665

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Title: In silico assessment of drug safety in human heart applied to late sodium current blockers
Author: Trénor Gomis, Beatriz Ana Gomis-Tena Dolz, Julio Cardona Urrego, Karen Eliana Romero Pérez, Lucia Rajamani, Sridharan Belardinelli, Luiz Giles, Wayne R. Saiz Rodríguez, Francisco Javier
UPV Unit: Universitat Politècnica de València. Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano - Institut Interuniversitari d'Investigació en Bioenginyeria i Tecnologia Orientada a l'Ésser Humà
Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica
Issued date:
Abstract:
Drug-induced action potential (AP) prolongation leading to Torsade de Pointes is a major concern for the development of anti-arrhythmic drugs. Nevertheless the development of improved anti-arrhythmic agents, some of which ...[+]
Subjects: Anti-arrhythmic , Drug safety , Multi-channel block , Reverse rate-dependence , Late sodium current , Transmural dispersion of repolarization
Copyrigths: Reserva de todos los derechos
Source:
Channels. (issn: 1933-6950 ) (eissn: 1933-6969 )
DOI: 10.4161/chan.24905
Publisher:
Landes Bioscience
Publisher version: http://dx.doi.org/10.4161/chan.24905
Project ID:
info:eu-repo/grantAgreement/MITURCO//TSI-020100-2010-0469/ES/LocMoTIC. Localización del Origen de Arritmias Cardíacas Mediante Modelado y Tecnologías de la Información y Comunicaciones/
info:eu-repo/grantAgreement/UPV//PAID-06-11-2002/
info:eu-repo/grantAgreement/GVA//PROMETEO%2F2012%2F030/ES/MEJORA EN LA PREVENCION Y TRATAMIENTO DE PATOLOGIAS CARDIACAS A TRAVES DE LA MODELIZACION MULTI-ESCALA Y LA SIMULACION COMPUTACIONAL (DIGITAL HEART)/
Thanks:
This work was supported by (1) Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica, (2) Plan Avanza en el marco de la Accion Estrategica de Telecomunicaciones y Sociedad de la Informacion del ...[+]
Type: Artículo

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