Codoñer Franch, P.; Betoret Valls, ME.; López Jaén, AB.; Betoret Valls, N.; Fito Maupoey, P.; Valls Bellés, MV. (2013). Dried apple enriched with mandarin juice counteracts tamoxifen induced oxidative stress in rats. International Journal of Food Sciences and Nutrition. 64(7):815-821. doi:10.3109/09637486.2013.798267
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/67999
Title:
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Dried apple enriched with mandarin juice counteracts tamoxifen induced oxidative stress in rats
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Author:
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Codoñer Franch, Pilar
Betoret Valls, María Ester
López Jaén, Ana Belén
Betoret Valls, Noelia
Fito Maupoey, Pedro
Valls Bellés, Maria Victoria
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UPV Unit:
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Universitat Politècnica de València. Departamento de Tecnología de Alimentos - Departament de Tecnologia d'Aliments
Universitat Politècnica de València. Instituto Universitario de Ingeniería de Alimentos para el Desarrollo - Institut Universitari d'Enginyeria d'Aliments per al Desenvolupament
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Issued date:
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Abstract:
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[EN] The effect of a product made of dehydrated apples enriched with mandarin juice by vacuum impregnation on markers of oxidative stress (plasma antioxidant capacity, carbonyl groups (CGs), 8-hydroxydeoxyguanosine (8OHdG) ...[+]
[EN] The effect of a product made of dehydrated apples enriched with mandarin juice by vacuum impregnation on markers of oxidative stress (plasma antioxidant capacity, carbonyl groups (CGs), 8-hydroxydeoxyguanosine (8OHdG) and alpha-tocopherol) was tested in rats. Six groups of animals were studied: one group was fed a standard diet; two groups were supplemented with dehydrated apple either impregnated or not with mandarin juice throughout 28 days; and three groups (one unsupplemented and two supplemented) were additionally treated with tamoxifen (TAM) for 21 days used for induction of oxidative stress. The rats treated with TAM showed an increase in aminotransferases, CGs and 8OHdG. All of these effects were significantly decreased in the animals after apple snack consumption; the addition of mandarin juice into the apple mainly accounts for increased levels of alpha-tocopherol in plasma and liver. These findings suggest that the food product have a protective action against oxidative stress induced by TAM in rats.
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Subjects:
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8-hydroxydeoxyguanosine
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Antioxidants
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Apple
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Citrus
,
Protein oxidation
,
Tamoxifen
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Copyrigths:
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Reserva de todos los derechos
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Source:
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International Journal of Food Sciences and Nutrition. (issn:
0963-7486
) (eissn:
1465-3478
)
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DOI:
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10.3109/09637486.2013.798267
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Publisher:
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INFORMA HEALTHCARE
Taylor & Francis
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Publisher version:
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https://dx.doi.org/10.3109/09637486.2013.798267
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Project ID:
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Ministerio de Ciencia e Innovacion of Spain PET2008_0015
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Thanks:
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We appreciate the support of the Ministerio de Ciencia e Innovacion of Spain for its contribution through project PET2008_0015.
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Type:
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Artículo
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