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Thermodynamic analysis of the thermal stability of sulphonamides in milk using liquid chromatography tandem mass spectrometry detection

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Thermodynamic analysis of the thermal stability of sulphonamides in milk using liquid chromatography tandem mass spectrometry detection

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dc.contributor.author Roca Marugán, Marta Isabel es_ES
dc.contributor.author ALTHAUS, RAFAEL LISANDRO es_ES
dc.contributor.author Molina Pons, Mª Pilar es_ES
dc.date.accessioned 2016-12-14T09:33:50Z
dc.date.available 2016-12-14T09:33:50Z
dc.date.issued 2013-01-15
dc.identifier.issn 0308-8146
dc.identifier.uri http://hdl.handle.net/10251/75196
dc.description.abstract [EN] The present study investigates the kinetics of the degradation of eight sulphonamides in skimmed milk when heated at 60, 70, 80, 90 and 100 degrees C using an LC-MS/MS methodology. To determine the thermal stability of these compounds, the first-order kinetic model was applied and the activation energies, half-lives and degradation percentages were calculated. Application of kinetic equations to the different heat treatments used in dairy processing indicates that sulphonamides are very stable during pasteurisation (63 degrees C; 30 min and 72 degrees C; 15 s) as well as UHT sterilisation (140 degrees C; 4 s). In contrast, the calculations performed with the kinetic model estimated losses in concentrations between 6.5% (sulfadimethoxine) and 85.1% (sulfamethazine) for the sterilisation at 120 degrees C for 20 min. The existence of thermodynamic compensation was also tested for sulphonamide degradation. Results show that enthalpy and entropy values displayed a good linear relationship, and thermodynamically we can establish that the thermal degradation of sulphonamides in skimmed milk exhibits enthalpy-entropy compensation. es_ES
dc.description.sponsorship This research has been supported financially by the Spanish Ministry of Education and Science (AGL2003-03663 project, Madrid, Spain) and has been carried out with the help of the Vice-rectorate of Research, Development and Innovation at the Polytechnic University of Valencia (Reference 6567). Moreover, the authors wish to thank the Polytechnic University of Valencia for funding the collaboration of Dr. Rafael Althaus with the Institute for Animal Science and Technology. en_EN
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation Spanish Ministry of Education and Science, Madrid, Spain AGL2003-03663 es_ES
dc.relation Vice-rectorate of Research, Development and Innovation at the Polytechnic University of Valencia 6567 es_ES
dc.relation Polytechnic University of Valencia es_ES
dc.relation.ispartof Food Chemistry es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Sulphonamides es_ES
dc.subject Milk es_ES
dc.subject Thermal stability es_ES
dc.subject First-order kinetic model es_ES
dc.subject Thermodynamic compensation es_ES
dc.subject.classification PRODUCCION ANIMAL es_ES
dc.title Thermodynamic analysis of the thermal stability of sulphonamides in milk using liquid chromatography tandem mass spectrometry detection es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.foodchem.2012.08.055
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal es_ES
dc.description.bibliographicCitation Roca Marugán, MI.; Althaus, RL.; Molina Pons, MP. (2013). Thermodynamic analysis of the thermal stability of sulphonamides in milk using liquid chromatography tandem mass spectrometry detection. Food Chemistry. 136:376-383. doi:10.1016/j.foodchem.2012.08.055 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://dx.doi.org/10.1016/j.foodchem.2012.08.055 es_ES
dc.description.upvformatpinicio 376 es_ES
dc.description.upvformatpfin 383 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 136 es_ES
dc.relation.senia 239807 es_ES


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