Romero-Méndez, R.; Tobajas, P.; Burdío Pinilla, F.; González, A.; Navarro Gonzalo, A.; Grande, L.; Berjano, E. (2012). Electrical-thermal performance of a cooled RF applicator for hepatic ablation with additional distant infusion of hypertonic saline: In vivo study and preliminary computer modeling. International Journal of Hyperthermia. 28(7):653-662. https://doi.org/10.3109/02656736.2012.711894
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/80515
Title:
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Electrical-thermal performance of a cooled RF applicator for hepatic ablation with additional distant infusion of hypertonic saline: In vivo study and preliminary computer modeling
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Author:
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Romero-Méndez, Ricardo
Tobajas, Pilar
Burdío Pinilla, Fernando
González, Ana
Navarro Gonzalo, Ana
Grande, Luis
Berjano, Enrique
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UPV Unit:
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Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny
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Issued date:
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Abstract:
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Purpose: The Cool-tip electrode is one of the most widely employed applicators in radiofrequency (RF) hepatic ablation.
Previous research demonstrated that it is possible to enlarge coagulation volume when the single ...[+]
Purpose: The Cool-tip electrode is one of the most widely employed applicators in radiofrequency (RF) hepatic ablation.
Previous research demonstrated that it is possible to enlarge coagulation volume when the single cooled electrode is
associated with distant infusion of saline (hybrid applicator). The aim of this study was to compare the electrical-thermal
behaviour of the Cool-tip electrode with that of the hybrid applicator.
Materials and methods: Forty-two RF ablations were performed on a total of 10 pigs: 22 with the Cool-tip electrode and 20
with the hybrid applicator (low infused saline volumetric flow rate of 6 mL/h at 2 mm distance). We compared both electrical
performance (delivered power and number of roll-offs, i.e. sudden rises in impedance that interrupt the power delivery) and
coagulation zone characteristics. In addition, we built a one-dimensional model to provide a basic physical explanation of the
difference in performance between the different applicators.
Results: The experimental results showed that the number of roll-offs with the Cool-tip electrode was higher (24.3 3.1
versus 6.7 7.0). The hybrid applicator created larger coagulation volumes (19.7 9.5 cm3 versus 9.5 5.8 cm3
) with
larger transverse diameters (2.5 0.6 versus 1.9 0.5 cm). The one-dimensional model confirmed the delay in the
incidence of the first roll-off, but not the heterogeneity of the hybrid applicator’s electrical performance in the
experiments.
Conclusions: The hybrid applicator produces fewer roll-off episodes than the Cool-tip electrode and creates larger coagulation
volumes with larger transverse diameters.
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Subjects:
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Cool-tip electrode
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Computer modelling
,
Hepatic ablation
,
Radiofrequency ablation
,
Saline infusion
,
Tumour ablation
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Copyrigths:
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Cerrado |
Source:
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International Journal of Hyperthermia. (issn:
0265-6736
)
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DOI:
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10.3109/02656736.2012.711894
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Publisher:
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Taylor & Francis
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Publisher version:
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http://dx.doi.org/10.3109/02656736.2012.711894
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Project ID:
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info:eu-repo/grantAgreement/MICINN//TEC2008-01369/ES/MODELOS COMPUTACIONALES E INVESTIGACION EXPERIMENTAL EN EL ESTUDIO DE TECNICAS QUIRURGICAS DE CALENTAMIENTO DE TEJIDOS BIOLOGICOS MEDIANTE CORRIENTES DE RADIOFRECUENCIA./
info:eu-repo/grantAgreement/MICINN//TEC2011-27133-C02-01/ES/MODELADO TEORICO Y EXPERIMENTACION PARA TECNICAS ABLATIVAS BASADAS EN ENERGIAS/
info:eu-repo/grantAgreement/CONACYT//CB-2007-84618/
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Thanks:
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This work received financial support from the Spanish Plan Nacional de I_D_i del Ministerio de Ciencia e Innovacion, grants TEC2008-01369/TEC and TEC2011-27133-C02-01. The authors thank CONACyT (Mexico) for support from ...[+]
This work received financial support from the Spanish Plan Nacional de I_D_i del Ministerio de Ciencia e Innovacion, grants TEC2008-01369/TEC and TEC2011-27133-C02-01. The authors thank CONACyT (Mexico) for support from project CB-2007/84618 that enabled research visits of R. Romero-Mendez to the Universidad Politecnica de Valencia (Spain) and E.J. Berjano to the Universidad Autonoma de San Luis Potosi (Mexico). The translation of this paper was funded by the Universitat Politecnica de Valencia, Spain. F. Burdio and E. Berjano declare an interest (stock ownership) in Apeiron Medical SL, a company which has a licence for the patent application US 2010/137856 A1, on which the hybrid applicator tested in this study is based. The other authors have no conflict of interests or financial ties to disclose. The authors alone are responsible for the content and writing of the paper.
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Type:
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Artículo
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