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Electrical-thermal performance of a cooled RF applicator for hepatic ablation with additional distant infusion of hypertonic saline: In vivo study and preliminary computer modeling

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Electrical-thermal performance of a cooled RF applicator for hepatic ablation with additional distant infusion of hypertonic saline: In vivo study and preliminary computer modeling

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dc.contributor.author Romero-Méndez, Ricardo es_ES
dc.contributor.author Tobajas, Pilar es_ES
dc.contributor.author Burdío Pinilla, Fernando es_ES
dc.contributor.author González, Ana es_ES
dc.contributor.author Navarro Gonzalo, Ana es_ES
dc.contributor.author Grande, Luis es_ES
dc.contributor.author Berjano, Enrique es_ES
dc.date.accessioned 2017-05-03T13:49:20Z
dc.date.available 2017-05-03T13:49:20Z
dc.date.issued 2012
dc.identifier.issn 0265-6736
dc.identifier.uri http://hdl.handle.net/10251/80515
dc.description.abstract Purpose: The Cool-tip electrode is one of the most widely employed applicators in radiofrequency (RF) hepatic ablation. Previous research demonstrated that it is possible to enlarge coagulation volume when the single cooled electrode is associated with distant infusion of saline (hybrid applicator). The aim of this study was to compare the electrical-thermal behaviour of the Cool-tip electrode with that of the hybrid applicator. Materials and methods: Forty-two RF ablations were performed on a total of 10 pigs: 22 with the Cool-tip electrode and 20 with the hybrid applicator (low infused saline volumetric flow rate of 6 mL/h at 2 mm distance). We compared both electrical performance (delivered power and number of roll-offs, i.e. sudden rises in impedance that interrupt the power delivery) and coagulation zone characteristics. In addition, we built a one-dimensional model to provide a basic physical explanation of the difference in performance between the different applicators. Results: The experimental results showed that the number of roll-offs with the Cool-tip electrode was higher (24.3 3.1 versus 6.7 7.0). The hybrid applicator created larger coagulation volumes (19.7 9.5 cm3 versus 9.5 5.8 cm3 ) with larger transverse diameters (2.5 0.6 versus 1.9 0.5 cm). The one-dimensional model confirmed the delay in the incidence of the first roll-off, but not the heterogeneity of the hybrid applicator’s electrical performance in the experiments. Conclusions: The hybrid applicator produces fewer roll-off episodes than the Cool-tip electrode and creates larger coagulation volumes with larger transverse diameters. es_ES
dc.description.sponsorship This work received financial support from the Spanish Plan Nacional de I_D_i del Ministerio de Ciencia e Innovacion, grants TEC2008-01369/TEC and TEC2011-27133-C02-01. The authors thank CONACyT (Mexico) for support from project CB-2007/84618 that enabled research visits of R. Romero-Mendez to the Universidad Politecnica de Valencia (Spain) and E.J. Berjano to the Universidad Autonoma de San Luis Potosi (Mexico). The translation of this paper was funded by the Universitat Politecnica de Valencia, Spain. F. Burdio and E. Berjano declare an interest (stock ownership) in Apeiron Medical SL, a company which has a licence for the patent application US 2010/137856 A1, on which the hybrid applicator tested in this study is based. The other authors have no conflict of interests or financial ties to disclose. The authors alone are responsible for the content and writing of the paper. en_EN
dc.language Inglés es_ES
dc.publisher Taylor & Francis es_ES
dc.relation Plan Nacional de I+D+i del Ministerio de Ciencia e Innovación (Spain) TEC2008-01369/TEC es_ES
dc.relation Plan Nacional de I+D+i del Ministerio de Ciencia e Innovación (Spain) TEC2011- 27133-C02-01 es_ES
dc.relation CONACyT (México) CB-2007/84618 es_ES
dc.relation Universitat Politècnica de Valencia (Spain) es_ES
dc.relation.ispartof International Journal of Hyperthermia es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Cool-tip electrode es_ES
dc.subject Computer modelling es_ES
dc.subject Hepatic ablation es_ES
dc.subject Radiofrequency ablation es_ES
dc.subject Saline infusion es_ES
dc.subject Tumour ablation es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Electrical-thermal performance of a cooled RF applicator for hepatic ablation with additional distant infusion of hypertonic saline: In vivo study and preliminary computer modeling es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3109/02656736.2012.711894
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny es_ES
dc.description.bibliographicCitation Romero-Méndez, R.; Tobajas, P.; Burdío Pinilla, F.; González, A.; Navarro Gonzalo, A.; Grande, L.; Berjano, E. (2012). Electrical-thermal performance of a cooled RF applicator for hepatic ablation with additional distant infusion of hypertonic saline: In vivo study and preliminary computer modeling. International Journal of Hyperthermia. 28(7):653-662. doi:10.3109/02656736.2012.711894 es_ES
dc.description.accrualMethod Senia es_ES
dc.relation.publisherversion http://dx.doi.org/10.3109/02656736.2012.711894 es_ES
dc.description.upvformatpinicio 653 es_ES
dc.description.upvformatpfin 662 es_ES
dc.type.version info:eu repo/semantics/publishedVersion es_ES
dc.description.volume 28 es_ES
dc.description.issue 7 es_ES
dc.relation.senia 235500 es_ES


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