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Browsing by Author "Salmerón Sánchez, Manuel"

Now showing items 1-20 of 65

A fractal nature for polymerized laminin

Hochman Méndez, Carlos; Cantini ., Marco; Moratal Pérez, David; Salmerón Sánchez, Manuel; Coelho-Sampaio, Tatiana (Public Library of Science, 2014-10)

Polylaminin (polyLM) is a non-covalent acid-induced nano- and micro-structured polymer of the protein laminin displaying distinguished biological properties. Polylaminin stimulates neuritogenesis beyond the levels achieved ...
Arrangement of Type IV Collagen and Laminin on Substrates with Controlled Density of ¿OH Groups

Coelho, Nuno Miranda; González García, Cristina; Salmerón Sánchez, Manuel; Altankov, George (Mary Ann Liebert, 2011)

Collagen IV (Col IV) and laminin (Lam) are the main structural components of the basement membrane where they form two overlapping polymeric networks. We studied the adsorption pattern of these proteins on five model ...
Arrangement of Type IV Collagen on NH2 and COOH Functionalized Surfaces

Miranda Coelho, Nuno; González García, Cristina; Salmerón Sánchez, Manuel; Altankov, George (Wiley-Blackwell, 2011-07)

Apart from the paradigm that cell-biomaterials interaction depends on the adsorption of soluble adhesive proteins we anticipate that upon distinct conditions also other, less soluble ECM proteins such as collagens, associate ...
Biodegradable poly(L-lactide) and polycaprolactone block copolymer networks

Escobar Ivirico, Jorge Luis; Salmerón Sánchez, Manuel; Gómez Ribelles, José Luís; Monleón Pradas, Manuel (Wiley, 2011)

New biodegradable block copolymer networks were synthesized from methacrylate-terminated poly(L-lactide) (mLA) and polycaprolactone (mCL) macromers. This allowed the realization of a series of materials in which the macromer ...
BIOLOGICAL ACTIVITY OF FIBRONECTIN AT THE CELL-MATERIAL INTERFACE

González García, Cristina (Universitat Politècnica de València, 2012-11-05)

Esta tesis aborda la actividad biológica de la fibronectina (FN) como proteína de interfase en la interacción célula-material. La tesis investiga la respuesta de la proteína, en términos de cantidad adsorbida y conformación, ...
Biological activity of the substrate-induced fibronectin network: Insight into the third dimension through electrospun fibers

Gugutkov, Dencho; González-García, Cristina; Rodríguez Hernández, José Carlos; Altankov, George; Salmerón Sánchez, Manuel (American Chemical Society, 2009)

[EN] Fibronectin (FN) fibrillogenesis is a cell-mediated process involving integrin activation that results in conformational changes of FN molecules and the organization of actin cytoskeleton. A similar process can be ...
Borax induces osteogenesis by stimulating NaBC1 transporter via activation of BMP pathway

Rico Tortosa, Patricia María; Rodrigo Navarro, Aleixandre; Sánchez-Pérez, Laura; Salmerón Sánchez, Manuel (Springer Nature, 2020-11-27)

[EN] The intrinsic properties of mesenchymal stem cells (MSCs) make them ideal candidates for tissue engineering applications. Efforts have been made to control MSC behavior by using material systems to engineer synthetic ...
Chondrocytes cultured in an adhesive macroporous scaffold subjected to stirred flow bioreactor behave like in static culture

Gamboa Martínez, Tatiana Carolina; Ródenas Rochina, Joaquín; Rico Tortosa, Patricia María; Lebourg, Myriam Madeleine; Gómez Ribelles, José Luís; Salmerón Sánchez, Manuel; Gallego Ferrer, Gloria (American Scientific Publishers, 2013)

[EN] The aim of this study was to evaluate whether mechanical stimulation helps to modulate the redifferentiation of human chondrocytes on adhesive 3D substrates. In a previous work, it was shown that chondrocytes seeded ...
Comportamiento mecánico de tres tipos de anudados quirúrgicos usando monofilamentos de 4/0

Gil Santos, Luis; Más Estellés, Jorge; Salmerón Sánchez, Manuel; Barrios, Carlos (Elsevier, 2012-07)

[ES] Objetivo Estudiar experimentalmente mediante ensayos mecánicos el comportamiento de 4 tipos de monofilamento con 3 diseños de nudo, muy frecuentemente utilizados en cirugía. Material y métodos Se eligieron 4 ...
Confined Sandwichlike Microenvironments Tune Myogenic Differentiation

Ballester Beltrán, José; Trujillo, Sara; Alakpa, Enateri V.; Compañ Moreno, Vicente; Gavara, Rafael; Meek, Dominic; West, Christopher C.; Peault, Bruno; Dalby, Matthew J.; Salmerón Sánchez, Manuel (American Chemical Society, 2017)

[EN] Sandwichlike (SW) cultures are engineered as a multilayer technology to simultaneously stimulate dorsal and ventral cell receptors, seeking to mimic cell adhesion in three-dimensional (3D) environments in a reductionist ...
Control de las propiedades mecánicas en materiales soporte para terapias regenerativas

Cantos Gómez, Antonio (Universitat Politècnica de València, 2013-12-10)

Consulta en la Biblioteca ETSI Industriales (7872)
Controlled Assembly of Fibronectin Nanofibrils Triggered by Random Copolymer Chemistry

MNATSAKANYAN, HAYK; Rico Tortosa, Patricia María; Grigoriou, Eleni; Maturana Candelas, Aarón; Rodrigo Navarro, Aleixandre; Salmerón Sánchez, Manuel; Sabater i Serra, Roser (American Chemical Society, 2015-08-19)

Fibronectin fibrillogenesis is the physiological process by which cells elaborate a fibrous FN matrix. Poly(ethyl acrylate), PEA, has been described to induce a similar process upon simple adsorption of fibronectin (FN) ...
Controlled wettability, same chemistry: biological activity of plasma-polymerized coatings

Cantini, Marco; Rico Tortosa, Patricia María; Moratal Pérez, David; Salmerón Sánchez, Manuel (Royal Society of Chemistry, 2012)

Plasma polymerization was used to produce novel nanometric coatings able to direct fibronectin adsorption and cell response. Using ethyl acrylate as a monomer, we obtain coatings whose chemical composition maintains some ...
Desarrollo de una herramienta informática para la predicción de la absorción competitiva en ingeniería de superficies para aplicaciones biomédicas

Hernández Saz, Jesús (Universitat Politècnica de València, 2013-12-10)

Consulta en la Biblioteca ETSI Industriales (7864)
Differentiation of Human Mesenchymal Stem Cells Toward Quality Cartilage Using Fibrinogen-Based Nanofibers

Forget, Jeremy; Awaja, Firas; Gugutkov, Dencho; Gustavsson, Juhan; Gallego Ferrer, Gloria; Coelho-Sampaio, Tatiana; Hochman-Mendez, Camila; Salmerón Sánchez, Manuel; Altankov, George (Wiley, 2016-09)

[EN] Mimicking the complex intricacies of the extra cellular matrix including 3D configurations and aligned fibrous structures were traditionally perused for producing cartilage tissue from stem cells. This study shows ...
Dorsal and Ventral Stimuli in Cell-Material Interactions: Effecton Cell Morphology

Ballester Beltrán, José; Lebourg, Myriam Madeleine; Rico Tortosa, Patricia María; Salmerón Sánchez, Manuel (American Vacuum Society, 2012-06)

Cells behave differently between bidimensional (2D) and tridimensional (3D) environments. While most of the in vitro cultures are 2D, most of the in vivo extracellular matrices are 3D, which encourages the development of ...
Dorsal and ventral stimuli in sandwich-like microenvironments. Effect on cell differentiation

Ballester Beltrán, José; Lebourg, Myriam Madeleine; Salmerón Sánchez, Manuel (Wiley, 2013-06-27)

While most of the in vivo extracellular matrices are 3D, most of the in vitro cultures are 2D--where only ventral adhesion is permitted--thus modifying cell behavior as a way to self-adaptation to this unnatural environment. ...
Effect of topological cues on material-driven fibronectinfibrillogenesis and cell differentiation

Ballester Beltrán, José; Cantini, Marco; Lebourg, Myriam Madeleine; Rico Tortosa, Patricia María; Moratal Pérez, David; García, Andrés J.; Salmerón Sánchez, Manuel (Springer Verlag (Germany), 2012-01)

[EN] Fibronectin (FN) assembles into fibrillar networks by cells through an integrin-dependent mechanism. We have recently shown that simple FN adsorption onto poly(ethyl acrylate) surfaces (PEA), but not control polymer ...
Engineered 3D hydrogels with full-length fibronectin that sequester and present growth factors

Trujillo-Muñoz, Sara; González-García, Cristina; Rico Tortosa, Patricia María; Reid, Andrew; Windmill, James; Dalby, Matthew J.; Salmerón Sánchez, Manuel (Elsevier, 2020-09)

[EN] Extracellular matrix (ECM)-derived matrices such as Matrigel are used to culture numerous cell types in vitro as they recapitulate ECM properties that support cell growth, organisation, migration and differentiation. ...
Engineered microenvironments for synergistic VEGF - Integrin signalling during vascularization

Moulisova, Vladimira; González García, Cristina; Cantini, Marco; Rodrigo Navarro, Aleixandre; Weaver, Jessica; Costell, Mercedes; Sabater i Serra, Roser; Dalby, Matthew J.; García, Andrés J.; Salmerón Sánchez, Manuel (Elsevier, 2017)

[EN] We have engineered polymer-based microenvironments that promote vasculogenesis both in vitro and in vivo through synergistic integrin-growth factor receptor signalling. Poly(ethyl acrylate) (PEA) triggers spontaneous ...