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Browsing by Author "Cardona Urrego, Karen Eliana"

Now showing items 1-7 of 7

A Comparative Study of Vaginal Labor and Caesarean Section Postpartum Uterine Myoelectrical Activity

Díaz-Martínez, María del Alba; Mas-Cabo, Javier; Prats-Boluda, Gema; Garcia-Casado, Javier; Cardona-Urrego, Karen; Monfort-Ortiz, Rogelio; Lopez-Corral, Angel; De Arriba-Garcia, Maria; Perales, Alfredo; Ye Lin, Yiyao (MDPI AG, 2020-06)

[EN] Postpartum hemorrhage (PPH) is one of the major causes of maternal mortality and morbidity worldwide, with uterine atony being the most common origin. Currently there are no obstetrical techniques available for ...
Cardiac action potential repolarization revisited: early repolarization shows all-or-none behaviour

Trenor Gomis, Beatriz Ana; Cardona-Urrego, Karen Eliana; Saiz Rodríguez, Francisco Javier; Noble, Denis; Giles, Wayne (Blackwell Publishing, 2017-11-01)

[EN] In healthy mammalian hearts the action potential (AP) waveform initiates and modulates each contraction, or heartbeat. As a result, AP height and duration are key physiological variables. In addition, rate-dependent ...
In silico assessment of drug safety in human heart applied to late sodium current blockers

Trénor Gomis, Beatriz Ana; Gomis-Tena Dolz, Julio; Cardona Urrego, Karen Eliana; Romero Pérez, Lucia; Rajamani, Sridharan; Belardinelli, Luiz; Giles, Wayne R.; Saiz Rodríguez, Francisco Javier (Landes Bioscience, 2013-07-01)

Drug-induced action potential (AP) prolongation leading to Torsade de Pointes is a major concern for the development of anti-arrhythmic drugs. Nevertheless the development of improved anti-arrhythmic agents, some of which ...
Lessons Learned from Multi-scale Modeling of the Failing Heart

Gómez García, Juan Francisco; Cardona-Urrego, Karen Eliana; Trénor Gomis, Beatriz Ana (Elsevier, 2015-12)

[EN] Heart failure constitutes a major public health problem worldwide. Affected patients experience a number of changes in the electrical function of the heart that predispose to potentially lethal cardiac arrhythmias. ...
Modelización matemática y simulación de los efectos de la lidocaína sobre la actividad eléctrica cardíaca en tejido ventricular

Cardona Urrego, Karen Eliana (Universitat Politècnica de València, 2008-08-04)

Hoy resulta más complejo que nunca abordar el estudio de los fármacos antiarrítmicos, en virtud de los vuelcos experimentados por la aparición de diferentes trabajos donde se ha comprobado la acción proarrítmica de este ...
Pro-arrhythmic Effects of Low Plasma [K+] in Human Ventricle: An Illustrated Review

Trénor Gomis, Beatriz Ana; Cardona-Urrego, Karen Eliana; Romero Pérez, Lucia; Gómez García, Juan Francisco; Saiz Rodríguez, Francisco Javier; Rajamani, Sridharan; Belardinelli, Luiz; Giles, Wayne (Elsevier, 2018)

[EN] Potassium levels in the plasma, [Kþ]o, are regulated precisely under physiological conditions. However, increases (from approx. 4.5 to 8.0 mM) can occur as a consequence of, e.g., endurance exercise, ischemic insult ...
Simulation and Mechanistic Investigation of the Arrhythmogenic Role of the Late Sodium Current in Human Heart Failure

Trénor Gomis, Beatriz Ana; Cardona Urrego, Karen Eliana; Gómez García, Juan Francisco; Rajamani, Sridharan; Ferrero De Loma-Osorio, José María; Belardinelli, Luiz; Saiz Rodríguez, Francisco Javier (Public Library of Science, 2012)

Heart failure constitutes a major public health problem worldwide. The electrophysiological remodeling of failing hearts sets the stage for malignant arrhythmias, in which the role of the late Na + current (I NaL) is ...