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Browsing by Author "Boada Acosta, Yadira Fernanda"

Now showing items 1-17 of 17

A systems engineering approach to model, tune and test synthetic gene circuits

Boada Acosta, Yadira Fernanda (Universitat Politècnica de València, 2018-11-16)

La biología sintética se define como la ingeniería de la biología: el (re)diseño y construcción de nuevas partes, dispositivos y sistemas biológicos para realizar nuevas funciones con fines útiles, que se basan en principios ...
Análisis y ajuste de un seguidor genético sintético de señales biomoleculares mediante la aplicación de técnicas de optimización multiobjetivo

Montalar Mendoza, Aida-Pilar (Universitat Politècnica de València, 2019-10-07)

[ES] La biología sintética permite reconstruir o diseñar sistemas biológicos mediante modelos y una serie de métodos y herramientas con fines específicos como podría ser predecir el comportamiento que presentan. En este ...
Contractivity of a genetic circuit with internal feedback and cell-to-cell communication

Picó-Marco, Enric; Boada-Acosta, Yadira Fernanda; Picó, Jesús; Vignoni, Alejandro (Elsevier, 2016)

[EN] We consider a realistic model of the synthetic gene circuit combining cell-to-cell communication system via quorum sensing, and a synthetic repressible promoter implementing intracellular negative feedback control. ...
Diseño e implementación de un controlador proporcional-integral (PI) para el control de la producción de proteínas

Monfort Llorens, Roger (Universitat Politècnica de València, 2019-09-30)

[ES] La biología sintética permite la construcción de circuitos genéticos con un comportamiento deseado, modificando y combinando diferentes elementos genéticos que existen en la naturaleza. El control y la regulación de ...
Diseño y aplicabilidad de un circuito genético basado en el control antitético en la síntesis de proteínas y metabolitos

Fraile López, Ana (Universitat Politècnica de València, 2020-09-08)

[ES] La biología sintética toma conceptos de ingeniería para el diseño y la construcción de circuitos genéticos con un comportamiento deseado, modificando y combinando diferentes elementos genéticos que ya existen en la ...
Engineered Control of Genetic Variability Reveals Interplay among Quorum Sensing, Feedback Regulation, and Biochemical Noise

Boada-Acosta, Yadira Fernanda; Vignoni, Alejandro; Picó, Jesús (American Chemical Society, 2017)

[EN] Stochastic fluctuations in gene expression trigger both beneficial and harmful consequences for cell behavior. Therefore, achieving a desired mean protein expression level while minimizing noise is of interest ...
Extended metabolic biosensor design for dynamic pathway regulation of cell factories

Boada-Acosta, Yadira Fernanda; Vignoni, Alejandro; Picó, Jesús; Carbonell, Pablo (Elsevier (Cell Press), 2020-07-24)

[EN] Transcription factor-based biosensors naturally occur in metabolic pathways to maintain cell growth and to provide a robust response to environmental fluctua-tions. Extended metabolic biosensors, i.e., the cascading ...
Gene expression modelling and simulation. Model reduction and noise

Boada Acosta, Yadira Fernanda (Universitat Politècnica de València, 2014-06-26)

[ES] Este trabajo aborda metodologías de modelado para el análisis y diseño de redes sintéticas de genes. Nuestro modelo para la bacteria E. coli. incluye: i) quorum sensing como un mecanismo de comunicación entre células ...
Gene Expression Space Shapes the Bioprocess Trade-Offs among Titer, Yield and Productivity

Santos-Navarro, Fernando Nóbel; Boada-Acosta, Yadira Fernanda; Vignoni, Alejandro; Picó, Jesús (MDPI AG, 2021-07)

[EN] Optimal gene expression is central for the development of both bacterial expression systems for heterologous protein production, and microbial cell factories for industrial metabolite production. Our goal is to fulfill ...
Integración de un modelo de carga metabólica en el análisis computacional de un circuito genético sintético

Oleas Palacios, Liliana Gricel (Universitat Politècnica de València, 2018-02-09)

In this project Weibe & Oyarzún¿s metabolic burden model will be integrated in the dynamic model of synthetic gene circuits. A circuit for control of protein expression, and a incoherent feedforwad one will be used. The ...
Modelado de sistemas bioquímicos: De la Ley de Acción de Masas a la Aproximación Lineal del Ruido

Picó Marco, Jesús Andrés; Vignoni, Alejandro; Picó i Marco, Enric; Boada Acosta, Yadira Fernanda (Universitat Politècnica de València, 2015-07-10)

[EN] In the last decade we have witnessed a growing application of engineering techniques to biology. Areas such as Systems Biology or, more recently, Synthetic Biology, get more and more attention from the engineers. ...
Multi-objective optimization framework to obtain model-based guidelines for tuning biological synthetic devices: an adaptive network case

Boada Acosta, Yadira Fernanda; Reynoso Meza, Gilberto; Picó Marco, Jesús Andrés; Vignoni, Alejandro (BioMed Central, 2016-03-11)

Background: Model based design plays a fundamental role in synthetic biology. Exploiting modularity, i.e. using biological parts and interconnecting them to build new and more complex biological circuits is one of the key ...
Multiobjective Identification of a Feedback Synthetic Gene Circuit

Boada-Acosta, Yadira Fernanda; Vignoni, Alejandro; Picó, Jesús (Institute of Electrical and Electronics Engineers, 2020-01)

[EN] Kinetic (i.e., dynamic) semimechanistic models based on the first principles are particularly important in systems and synthetic biology since they can explain and predict the functional behavior that emerges from the ...
Optimization Alternatives for Robust Model-based Design of Synthetic Biological Circuits

Boada-Acosta, Yadira Fernanda; Pitarch Pérez, Jose Luis; Vignoni, Alejandro; Reynoso Meza, Gilberto; Picó, Jesús (Elsevier, 2016)

[EN] Synthetic biology is reaching the situation where tuning devices by hand is no longer possible due to the complexity of the biological circuits being designed. Thus, mathematical models need to be used in order, not ...
Parameter Identification in Synthetic Biological Circuits Using Multi-Objective Optimization

Boada-Acosta, Yadira Fernanda; Vignoni, Alejandro; Reynoso Meza, Gilberto; Picó, Jesús (Elsevier, 2016)

[EN] Synthetic biology exploits the of mathematical modeling of synthetic circuits both to predict the behavior of the designed synthetic devices, and to help on the selection of their biological coin portents. The increasing ...
PID controller tuning for unstable processes using a multi-objective optimisation design procedure

Reynoso-Meza, Gilberto; Carrillo Ahumada, J.; Boada-Acosta, Yadira Fernanda; Picó, Jesús (Elsevier, 2016)

[EN] Multi-objective optimisation techniques have shown to be a useful tool for controller tuning applications. Such techniques are useful when: 1) it is difficult to find a controller with a desirable trade-off between ...
RBS and Promoter Strengths Determine the Cell-Growth-Dependent Protein Mass Fractions and Their Optimal Synthesis Rates

Santos-Navarro, Fernando Nóbel; Vignoni, Alejandro; Boada-Acosta, Yadira Fernanda; Picó, Jesús (American Chemical Society, 2021-12-17)

[EN] Models of gene expression considering host-circuit interactions are relevant for understanding both the strategies and associated trade-offs that cell endogenous genes have evolved and for the efficient design of ...