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Browsing by Author "Candela Noguera, Vicente"

Now showing items 1-12 of 12

Antibacterial Activity of Linezolid against Gram-Negative Bacteria: Utilization of E-Poly-l-Lysine Capped Silica Xerogel as an Activating Carrier

Guzel Kaya, Gulcihan; Medaglia, Serena; Candela-Noguera, Vicente; Tormo-Mas, María Ángeles; Marcos Martínez, María Dolores; Aznar, Elena; Deveci, Huseyin; Martínez-Máñez, Ramón (MDPI AG, 2020-11)

[EN] In recent times, many approaches have been developed against drug resistant Gram-negative bacteria. However, low-cost high effective materials which could broaden the spectrum of antibiotics are still needed. In this ...
Biocompatibility and internalization assessment of bare and functionalised mesoporous silica nanoparticles

Garrido-Cano, Iris; Candela-Noguera, Vicente; Herrera, Guadalupe; Cejalvo, Juan Miguel; Lluch, Ana; Marcos Martínez, María Dolores; Sancenón Galarza, Félix; Eroles, Pilar; Martínez-Máñez, Ramón (Elsevier, 2021-01)

[EN] We report herein an evaluation of the effect of several mesoporous silica nanoparticles (MSNs) on the cellular uptake and in vitro cytotoxicity in human cells. Bare MSNs and MSNs functionalized with polyethylene glycol ...
Delivery of miR-200c-3p Using Tumor-Targeted Mesoporous Silica Nanoparticles for Breast Cancer Therapy

Garrido-Cano, Iris; Adam-Artigues, Anna; Lameirinhas, Ana; Blandez, Juan F.; Candela-Noguera, Vicente; Lluch, Ana; Bermejo, Begoña; Sancenón Galarza, Félix; Cejalvo, Juan Miguel; Martínez-Máñez, Ramón; Eroles, Pilar (American Chemical Society, 2023-08)

[EN] Despite advancesin breast cancer treatment, it remainsthe leadingcause of cancer-related death in women worldwide. In this context,microRNAs have emerged as potential therapeutic targets but stillpresent some limitations ...
Design of oligonucleotide-capped mesoporous silica nanoparticles for the detection of miRNA-145 by duplex and triplex formation

Ribes, Àngela; Santiago Felipe, Sara; Aviñó, Anna; Candela-Noguera, Vicente; Eritja, Ramón; Sancenón Galarza, Félix; Martínez-Máñez, Ramón; Aznar, Elena (Elsevier, 2018-12)

[EN] The development of new strategies to detect microRNAs (miRNAS) has become an important challenge in thebiomedical ¿eld. We report herein the use of oligonucleotide-gated silica nanoparticles for the detection ofmiRNA-145. ...
Diseño de materiales híbridos orgánico-inorgánicos para el reconocimiento de miRNA145

Candela Noguera, Vicente (Universitat Politècnica de València, 2016-06-06)

[ES] Este trabajo final de máster surge de la necesidad de desarrollar un sistema de detección sencillo y rápido para la detección de miRNAs como una estrategia general que podría ser muy útil en aplicaciones biomédicas. ...
Gene-Directed Enzyme Prodrug Therapy by Dendrimer-Like Mesoporous Silica Nanoparticles against Tumor Cells

Candela-Noguera, Vicente; Vivo-Llorca, Gema; Díaz de Greñu, Borja; Alfonso, María; Aznar, Elena; Orzáez, Mar; Marcos Martínez, María Dolores; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (MDPI AG, 2021-05)

[EN] We report herein a gene-directed enzyme prodrug therapy (GDEPT) system using gated mesoporous silica nanoparticles (MSNs) in an attempt to combine the reduction of side effects characteristic of GDEPT with improved ...
In-depth study of factors affecting the formation of MCM-41-type mesoporous silica nanoparticles

Candela-Noguera, Vicente; Alfonso, María; Amorós, Pedro; Aznar, Elena; Marcos Martínez, María Dolores; Martínez-Máñez, Ramón (Elsevier, 2024-01-01)

[EN] Mesoporous silica nanoparticles (MSN), especially MCM-41 type, have been broadly studied and used in different applications such as catalysis, nanomedicine and environmental science. One of the most advantageous ...
miR-99a-5p modulates doxorubicin resistance via the COX-2/ABCG2 axis in triple-negative breast cancer: from the discovery to in vivo studies

Garrido-Cano, Iris; Adam-Artigues, Anna; Lameirinhas, Ana; Blandez, Juan F.; Candela-Noguera, Vicente; Rojo, Federico; Zazo, Sandra; Madoz-Gúrpide, Juan; Lluch, Ana; Bermejo, Begoña; Sancenón Galarza, Félix; Cejalvo, Juan Miguel; Martínez-Máñez, Ramón; Eroles, Pilar (American Association for Cancer Research, 2022-12)
MUC1 Aptamer-Capped Mesoporous Silica Nanoparticles for Navitoclax Resistance Overcoming in Triple-Negative Breast Cancer

Vivo-Llorca, Gema; Candela-Noguera, Vicente; Alfonso-Navarro, María; García-Fernández, Alba; Orzáez, Mar; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (John Wiley & Sons, 2020-10-09)

[EN] Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. In the last years, navitoclax has emerged as a possible treatment for TNBC. Nevertheless, rapid navitoclax resistance onset has been ...
Study, development and improvement of MCM-41-type MSN synthesis oriented to biomedical applications

Candela Noguera, Vicente (Universitat Politècnica de València, 2022-04-26)

[ES] La presente tesis doctoral, titulada "Estudio, desarrollo y mejora de la síntesis de nanopartículas mesoporosas de sílice (MSN) tipo MCM-41 orientada a aplicaciones biomédicas" se centra en la síntesis, caracterización, ...
Systematic study of the implications of calcination and solvent extraction of the surfactant in MCM-41-type mesoporous silica nanoparticles

Candela-Noguera, Vicente; Amorós, Pedro; Aznar, Elena; Marcos Martínez, María Dolores; Martínez-Máñez, Ramón (Elsevier, 2024-06-01)

[EN] Mesoporous silica nanoparticles (MSN) have been growing in recent years in a broad range of applications, such as nanomedicine, catalysis, and gas storage. For the preparation of MSN, especially in nanomedicine ...
Toxicological Profiling and Long-Term Effects of Bare, PEGylated- and Galacto-Oligosaccharide-Functionalized Mesoporous Silica Nanoparticles

Barguilla, Irene; Candela-Noguera, Vicente; Oliver, Patrick; Annangi, Balasubramanyan; Diez-Sánchez, Paula; Aznar, Elena; Martínez-Máñez, Ramón; Marcos, R.; Hernández, A.; Marcos Martínez, María Dolores (MDPI AG, 2023-11)

[EN] Mesoporous silica nanoparticles (MSNs) are amongst the most used nanoparticles in biomedicine. However, the potentially toxic effects of MSNs have not yet been fully evaluated, being a controversial matter in research. ...