Vayá Pérez, Ignacio; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(American Chemical Society, 2007)
[EN] Fluorescence and laser-flash photolysis measurements have been performed on two pairs of diastereomeric dyads that contain the nonsteroidal anti-inflammatory drug (S)- or (R)-flurbiprofen (FBP) and (S)-tryptophan ...
Bonancía Roca, Paula; Vayá Pérez, Ignacio; Climent Olmedo, María José; Gustavsson, Thomas; Markovitsi, Dimitra; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(American Chemical Society, 2012-09-06)
Excited-state interactions between (S)- or (R) fluorescence (S)- or (R)-FBP) and thymidine (dThd) covalently linked in dyads 1 or 2 have been investigated. In both dyads, the only emitting species is (FBP)-F-1*, but with ...
[EN] The publication deals with polymeric pA·pT and oligomeric A(20)·T(20) DNA duplexes whose fluorescence is studied by time-correlated single photon counting. It is shown that their emission on the nanosecond timescale ...
García-Laínez, G.; Vayá Pérez, Ignacio; Marín, Mª Pilar; Miranda Alonso, Miguel Ángel; Andreu Ros, María Inmaculada(Springer-Verlag, 2021-01)
[EN] The epidermal growth factor receptors EGFR and HER2 are the main targets for tyrosine kinase inhibitors (TKIs). The quinazoline derivative lapatinib (LAP) is used since 2007 as dual TKI in the treatment of metastatic ...
Blasco-Brusola, Alejandro; Vayá Pérez, Ignacio; Miranda Alonso, Miguel Ángel(American Chemical Society, 2020-11-06)
[EN] Benzophenone (BP) is present in a variety of bioactive molecules. This chromophore is able to photosensitize DNA damage, where one of the most relevant BP/ DNA interactions occurs with thymine (Thy). In view of the ...
Vayá Pérez, Ignacio; Gustavsson, Thomas; Markovitsi, Dimitra; Miranda Alonso, Miguel Ángel; Jiménez Molero, María Consuelo(Elsevier, 2016-05-15)
[EN] The photoreactivity of diastereomeric dyads containing (S)- or (R)-flurbiprofen (FBP) and (S)-Tyr, either directly linked (1) or separated by a cyclic spacer (3) has been investigated. The main feature is a remarkable ...
Bonancía Roca, Paula; Vayá Pérez, Ignacio; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(American Chemical Society, 2012-12-27)
The two enantiomers of 2-(2-hydroxybiphenyl-4-yl)propanoic acid ((S)- and (R)-BPOH) have been selected as probes for human serum albumin (HSA). Photophysical characterization in the absence of protein led to emission maxima, ...
Vayá Pérez, Ignacio; Andreu Ros, María Inmaculada; Monje-López, Vicente Tomás; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(American Chemical Society, 2016-01)
[EN] The photoreactivity of fenofibric acid (FA) in the presence of human and bovine serum albumins (HSA and BSA, respectively) has been investigated by steady-state irradiation, fluorescence, and laser flash photolysis ...
Blasco Brusola, Alejandro(Universitat Politècnica de València, 2021-04-13)
[ES] La luz solar puede producir daños en el ADN por absorción directa de luz UVB, o por fotosensibilización tras la absorción de luz UVA por parte de fármacos, que pueden actuar como fotosensibilizadores (PS). La benzofenona ...
Vayá Pérez, Ignacio; Lhiaubet-Vallet, Virginie Lyria; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(Royal Society of Chemistry, 2014-03-18)
[EN] The properties of singlet and triplet excited states are strongly medium-dependent.
Hence, these species constitute valuable tools as reporters to probe compartmentalised
microenvironments, including drug@protein ...
Vayá Pérez, Ignacio; Andreu Ros, María Inmaculada; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(Royal Society of Chemistry, 2014)
The photooxygenation of model compounds containing the two enantiomers of naproxen (NPX) covalently
linked to histidine (His), tryptophan (Trp) and tyrosine (Tyr) has been investigated by steady state
irradiation, ...
[EN] The electrochemical and photophysical properties of a family of conjugated ligands and their iridium(III) cyclometallated complexes are described. They consist of a series of monocationic Ir-III bis-2-phenylpyridine ...
Tamarit-Mayo, Lorena; El Ouardi, Meryem; Andreu Ros, María Inmaculada; Vayá Pérez, Ignacio; Miranda Alonso, Miguel Ángel(The Royal Society of Chemistry, 2021-09-28)
[EN] Gefitinib (GFT) is a tyrosine kinase inhibitor currently used for the treatment of metastatic non-small cell lung cancer. Although it has been suggested that GFT can be phototoxic, there are no systematic studies on ...
Andreu Ros, María Inmaculada; Lence, Emilio; González-Bello, Concepción; Mayorga, Cristobalina; Cuquerella Alabort, Maria Consuelo; Vayá Pérez, Ignacio; Miranda Alonso, Miguel Ángel(Frontiers Media SA, 2020-10-30)
[EN] Lapatinib (LAP) is an anticancer drug generally used to treat breast and lung cancer. It exhibits hypersensitivity reactions in addition to dermatological adverse effects and photosensitivity. Moreover, LAP binds to ...
Blasco-Brusola, Alejandro; Navarrete-Miguel, Miriam; Giussani, Angelo; Roca-Sanjuan, Daniel; Vayá Pérez, Ignacio; Miranda Alonso, Miguel Ángel(The Royal Society of Chemistry, 2020-09-21)
[EN] The photoinduced cycloreversion of oxetanes has been thoroughly investigated in connection with the photorepair of the well-known DNA (6-4) photoproducts. In the present work, the direct photolysis of the two regioisomers ...
Blasco-Brusola, Alejandro; Vayá Pérez, Ignacio; Miranda Alonso, Miguel Ángel(The Royal Society of Chemistry, 2020-11-28)
[EN] Direct absorption of UVB light by DNA may induce formation of cyclobutane pyrimidine dimers and pyrimidine-pyrimidone (6-4) photoproducts. The latter arise from the rearrangement of unstable oxetane intermediates, ...
Belda Marqués, Núria(Universitat Politècnica de València, 2021-10-06)
[ES] En este trabajo de fin de grado se han sintetizado nanopartículas esféricas de oro (AuNPs) con
un diámetro de 2-4 nm, las cuales han sido funcionalizadas con polietilenglicol (PEG), diferentes
proteínas (HSA, BSA, ...
Vayá Pérez, Ignacio; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(Elsevier, 2005)
[EN] Three stereoisomeric salts of naproxen (NPX) with arginine (Arg), namely (S)-NPX/(S)-Arg, (R)-NPX/(S)-Arg and (S)NPX/(R)-Arg, have been prepared, and their fluorescence spectra recorded in solution and in the solid ...
Bonancía Roca, Paula; Vayá Pérez, Ignacio; Markovitsi, Dimitra; Gustavsson, Thomas; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(Royal Society of Chemistry, 2013)
The photochemical processes occurring in diastereomeric dyads (S, S)-1 and (S, R)-1, prepared by conjugation of (S)-2-(2-hydroxy-1,1'-biphenyl-4-yl) propanoic acid ((S)-BPOH) with (S)- and (R)-Trp, have been investigated. ...
Tamarit-Mayo, Lorena; El Ouardi, Meryem; Lence, Emilio; Andreu, Inmaculada; González-Bello, Concepción; Vayá Pérez, Ignacio; Miranda Alonso, Miguel Ángel(The Royal Society of Chemistry, 2022-08-24)
[EN] Photosensitization by drugs is directly related with the excited species and the photoinduced processes arising from interaction with UVA light. In this context, the ability of gefitinib (GFT), a tyrosine kinase ...