[EN] 'Communication' between abiotic nanoscale chemical systems is an almost-unexplored field with enormous potential. Here we show the design and preparation of a chemical communication system based on enzyme-powered Janus ...
VIDAURRE AGUT, CARLA MARIA; Rivero-Buceta, Eva María; Landry, Christopher C.; BOTELLA ASUNCION, PABLO(MDPI AG, 2021-05)
[EN] To understand the factors that control the formation of the biomolecular corona, a systematic study of the adsorption of several miRNAs shown to be important in prostate cancer on amine-functionalized mesoporous silica ...
Vivo Llorca, Gema(Universitat Politècnica de València, 2021-07-26)
[ES] La presente tesis doctoral titulada "Mesoporous silica and gold-based nanodevices: new controlled delivery platforms for biomedical applications" se centra en el diseño, síntesis, caracterización y evaluación de ...
[EN] Cancer immunotherapy has emerged in the past decade as a promising strategy for treating many forms of cancer by stimulating the patient's immune system. Although immunotherapy has achieved some promising results in ...
[EN] Mucin 1 (MUC1) is a cell surface protein overexpressed in breast cancer. Mesoporous silica nanoparticles (MSNs) loaded with safranin O, functionalized with aminopropyl groups and gated with the negatively charged MUC1 ...
García-Fernández, Alba; Vivo-Llorca, Gema; Sancho, Mónica; García-Jareño, Alicia Belén; Ramírez-Jiménez, Laura; Barber-Cano, Eloísa; Murguía, Jose R.; Orzaez, Mar; Sancenón Galarza, Félix; Martínez-Máñez, Ramón(The Royal Society of Chemistry, 2022-07)
[EN] In this article, we report one of the few examples of nanoparticles capable of simultaneously delivering CRISPR-Cas9 gene-editing machinery and releasing drugs for one-shot treatments. Considering the complexity of ...
Garrido-García, Eva María; Alfonso-Navarro, María; Díaz de Greñu-Puertas, Borja; Lozano-Torres, Beatriz; Parra Álvarez, Margarita; Gaviña, Pablo; Marcos Martínez, María Dolores; Martínez-Máñez, Ramón; Sancenón Galarza, Félix(John Wiley & Sons, 2020-03-02)
[EN] This work reports the synthesis, characterization,
and sensing behavior of a hybrid nanodevice for the detection of the potent abuse drug 25I-NBOMe. The system
is based on mesoporous silica nanoparticles, loaded ...
De la Torre Paredes, Cristina(Universitat Politècnica de València, 2018-01-08)
La presente tesis doctoral, titulada "Nanotecnología y química supramolecular en procesos de liberación controlada y reconocimiento molecular para aplicaciones biomédicas", se centra en dos temas importantes: el reconocimiento ...
Godoy Reyes, Tania Mariel(Universitat Politècnica de València, 2020-12-10)
[ES] La presente tesis doctoral titulada "Reconocimiento de neurotransmisores basado en nanopartículas de oro y de sílice mesoporosa para aplicaciones de detección y liberación controlada" es una tesis realizada por compendio ...
[EN] One appealing concept in the field of hybrid materials is related to the design of gated materials. These materials are prepared in such a way that the release of chemical or biochemical species from voids of porous ...
Lo Presti, Maria(Universitat Politècnica de València, 2021-09-02)
[ES] La presente tesis doctoral titulada "Detección óptica de especies químicas de importancia ambiental y biológica utilizando sensores moleculares y materiales híbridos" se centra en el diseño, preparación, caracterización ...
[EN] The induction of senescence produces a stable cell cycle arrest in cancer cells, thereby inhibiting tumor growth; however, the incomplete immune cell-mediated clearance of senescent cells may favor tumor relapse, ...
Gomez Lopez, Lucia(Universitat Politècnica de València, 2022-07-18)
[ES] El Nano Spray Dryer es un equipo de secado por atomización (Spray-Drying) capaz de producir partículas en la escala nanométrica a partir de disoluciones y suspensiones. Entre otras aplicaciones, esta técnica de secado ...
Garrido Cano, Iris(Universitat Politècnica de València, 2022-01-21)
[ES] La presente tesis doctoral, titulada "papel del miR-99a-5p en cáncer de mama: transformando hallazgos moleculares en herramientas clínicas" está centrada en el estudio del microRNA miR-99a-5p en cáncer de mama y en ...
Climent Terol, Estela; Mondragón Martínez, Laura; Martínez Mañez, Ramón; Sancenón Galarza, Félix; Marcos Martínez, María Dolores; Murguía Ibáñez, José Ramón; Amoros del Toro, Pedro Jose; Rurack, Knut; Pérez Payá, Enrique(Wiley-VCH Verlag, 2013-07-10)
The coupling of gated-indicator delivery with highly specific biochemical recognition is an innovative strategy for the detection of DNA sequences, able to compete with classical methods which need PCR amplification, in ...
[EN] A nanodevice based on mesoporous silica nanoparticles with rhodamine B in the pore framework, functionalized with carboxylates on the outer surface and capped with the cationic polymyxin B peptide, was used to selectively ...
Candela Noguera, Vicente(Universitat Politècnica de València, 2022-04-26)
[ES] La presente tesis doctoral, titulada "Estudio, desarrollo y mejora de la síntesis de nanopartículas mesoporosas de sílice (MSN) tipo MCM-41 orientada a aplicaciones biomédicas" se centra en la síntesis, caracterización, ...
[EN] Acute lung injury (ALI) is a critical inflammatory syndrome, characterized by increased diffuse inflammation and severe lung damage, which represents a clinical concern due to the high morbidity and mortality in ...
A new approach towards the design of "gated scaffolds" based on the combination of capped mesoporous silica nanoparticles (MSNs) with porous biomaterials is reported. Using this approach, a 3D gelatin-based scaffold able ...
[EN] Mesoporous silica nanoparticles (MSNs) are amongst the most used nanoparticles in
biomedicine. However, the potentially toxic effects of MSNs have not yet been fully evaluated,
being a controversial matter in research. ...