Ferrero De Loma-Osorio, José María; Trénor Gomis, Beatriz Ana; Romero Pérez, Lucia(Oxford University Press (OUP), 2014-03)
[EN] Ischaemic heart disease is considered as the single most frequent cause of death, provoking more than 7 000 000 deaths every year worldwide. A high percentage of patients experience sudden cardiac death, caused in ...
Romero Pérez, Lucia; Trénor Gomis, Beatriz Ana; Ferrero De Loma-Osorio, José María; Starmer, C. Frank(Public Library of Science, 2013-11)
The distribution of cellular source-sink relationships plays an important role in cardiac propagation. It can lead to conduction slowing and block as well as wave fractionation. It is of great interest to unravel the ...
[EN] Assessment of drug cardiotoxicity is crucial in the development of new compounds and is typically addressed by evaluating the blockade they cause in the potassium human ether-à-go-go related gene (hERG) channels. Our ...
Cano García, Jordi(Universitat Politècnica de València, 2021-03-22)
[ES] Las enfermedades cardiovasculares siguen siendo la principal causa de muerte en Europa. Las arritmias cardíacas son una causa importante de muerte súbita, pero sus mecanismos son complejos. Esto denota la importancia ...
[EN] Potassium levels in the plasma, [Kþ]o, are regulated precisely under physiological conditions. However, increases (from approx. 4.5 to
8.0 mM) can occur as a consequence of, e.g., endurance exercise, ischemic insult ...
Cano, Jordi; Zorio, Esther; Mazzanti, Andrea; Arnau, Miguel Ángel; Trenor Gomis, Beatriz Ana; Priori, Silvia G.; Saiz Rodríguez, Francisco Javier; Romero Pérez, Lucia(Frontiers Media SA, 2020-12-17)
[EN] The prolongation of the QT interval represents the main feature of the long QT syndrome (LQTS), a life-threatening genetic disease. The heterozygous SCN5A V411M mutation of the human sodium channel leads to a LQTS ...
Mora Fenoll, María Teresa; Ferrero De Loma-Osorio, José María; Romero Pérez, Lucia; Trénor Gomis, Beatriz Ana(Public Library of Science, 2017)
[EN] Abnormal intracellular Ca2+ handling is the major contributor to the depressed cardiac contractility observed in heart failure. The electrophysiological remodeling associated with this pathology alters both the action ...
Puche-García, Violeta; Romero Pérez, Lucia; Saiz Rodríguez, Francisco Javier(Universidad de Valladolid, 2022-11-25)
[ES] La terapia farmacológica es la primera línea contra la fibrilación auricular; aunque los mecanismos no se comprenden por completo. Nuestro objetivo es comparar datos experimentales a nivel unicelular de varios fármacos ...
[EN] Genetic mutations affecting genes encoding for ion channel protein structures have been associated with the presence of atrial fibrillation (AF) in healthy individuals. The aim of this study is to model and simulate ...
Romero Pérez, Lucia; Carbonell Pascual, Beatriz; Trenor Gomis, Beatriz Ana; Rodríguez, Blanca; Saiz Rodríguez, Francisco Javier; Ferrero De Loma-Osorio, José María(Elsevier, 2011-10)
[EN] Several mathematical models of rabbit ventricular action potential (AP) have been proposed to investigate mechanisms of arrhythmias and excitation-contraction coupling. Our study aims at systematically characterizing ...
This repository contains the Matlab functions used in [1] and six Excel files named “Tx matrix KrKsCaL.xlsx”, “Tx matix KrNaLCaL.xlsx”, “TqNet matrix KrKsCaL.xlsx”, “TqNet matrix KrNaLCaL.xlsx”, "Ttirang matrix KrKsCaL.xlsx" ...
Gomis-Tena Dolz, Julio; Brown, Brandon M.; Cano, Jordi; Trenor Gomis, Beatriz Ana; Yang, Pei-Chi; Saiz Rodríguez, Francisco Javier; Clancy, Colleen E.; Romero Pérez, Lucia(American Chemical Society, 2020-03-23)
[EN] Preclinical assessment of drug-induced proarrhythmicity is typically evaluated by the potency of the drug to block the potassium human ether-a-go-go-related gene (hERG) channels, which is currently quantified by the ...