Salmerón Sánchez, Manuel; Rico Tortosa, Patricia María; Moratal Pérez, David; Lee, Ted T.; Schwarzbauer, Jean E.; Garcia, Andres J.(Elsevier, 2011)
Fibronectin (FN) is a ubiquitous extracellular matrix protein (ECM) protein that is organized into fibrillar networks by cells through an integrin-mediated process that involves contractile forces. This assembly allows for ...
[EN] Protein remodeling at the cell material interface is an important phenomenon that should be incorporated into the design of advanced biomaterials for tissue engineering. In this work, we address the relationship between ...
Ballester Beltrán, José; Rico Tortosa, Patricia María; Moratal Pérez, David; Song, Wenlong; Mano, Joao F; Salmerón Sánchez, Manuel(Royal Society of Chemistry, 2011)
Protein adsorption and cellular behavior depend strongly on the wettability of substrates. Such studies are scarce for surfaces exhibiting extreme values of contact angles. Fibronectin (FN) adsorption and adhesion of ...
Background: The cell-material interaction is a complex bi-directional and dynamic process that mimics to a certain extent the natural interactions of cells with the extracellular matrix. Cells tend to adhere and rearrange ...
Ballester Beltrán, José(Universitat Politècnica de València, 2015-03-20)
Abstract
While most of the in vitro cultures are carried out on bi-dimensional (2D)
substrates, most of the in vivo extracellular matrices are threedimensional
(3D). Consequently cells behave differently on 2 ...
[EN] Boron ion is essential in metabolism and its concentration is regulated by ion-channel NaBC1. NaBC1 mutations cause corneal dystrophies such as Harboyan syndrome. Here we propose a 3D molecular model for NaBC1 and ...
Brígido Diego, Raúl(Universitat Politècnica de València, 2008-05-07)
El desarrollo de la ingeniería tisular, nace por la necesidad de dar solución a la gran cantidad de enfermedades que se dan por el deterioro de los tejidos mediante la utilización de células vivas para la regeneración del ...
Escobar Ivirico, Jorge Luis(Universitat Politècnica de València, 2008-10-27)
La ingeniería tisular es una ciencia multidisciplinaria que incluye tanto los principios fundamentales de la ingeniería de materiales como de la biología celular y molecular para dar lugar al desarrollo de tejidos y órganos ...
García Cruz, Dunia Mercedes; Salmerón Sánchez, Manuel; Gómez Ribelles, José Luís(Wiley, 2012-09)
The aim of this study is to show the favorable effect of simple dynamic culture conditions on chondrogenesis of previously expanded human chondrocytes seeded in a macroporous scaffold with week cell-pore walls adhesion. ...
[EN] Epoxy/polyaniline nanocomposites have been prepared by in situ polymerization of aniline carried out in hydrophilic epoxy networks based on polyoxyethylene (POE) swollen in aqueous solutions of aniline hydrochloride. ...
Brizuela Guerra, Nayrim; González-García, Cristina; Llopis, Virginia; Rodriguez-Hernandez, Jose Carlos; Moratal, David; Rico Tortosa, Patricia María; Salmerón Sánchez, Manuel(The Royal Society of Chemistry, 2010)
[EN] A family of polymer substrates which consists of a vinyl backbone chain with the side groups
¿COO(CH2)xCH3, with x ¿ 0, 1, 3, 5 was prepared. Substrates with decreasing stiffness, characterised
by the elastic modulus ...
González García, Cristina; Moratal Pérez, David; Oreffo, Richard O.C.; Dalby, Matthew J.; Salmerón Sánchez, Manuel(Royal Society of Chemistry, 2012)
A family of polymer substrates which consists of a vinyl backbone chain with the side groups -COO(CH2)(x)H, with x = 1, 2, 4, was prepared. Substrates with similar chemical groups but decreasing stiffness, characterized ...
Luo, Jiajun; Walker, Matthew; Xiao, Yinbo; Donnelly, Hannah; Dalby, Matthew J.; Salmerón Sánchez, Manuel(Ke Ai Publishing Communications Ltd., 2022-09)
[EN] Nanotopography presents an effective physical approach for biomaterial cell manipulation mediated through material-extracellular matrix interactions. The extracellular matrix that exists in the cellular microenvironment ...
Cells assemble fibronectin (FN) into fibrils in a process mediated by integrins. For this process to occur, it is known that the presence of other serum proteins is necessary. However, the individual effect of these proteins ...
[EN] While much work has been done in the design of biomaterials to control integrin-mediated adhesion, less emphasis has been put on functionalization of materials with cadherin ligands. Yet, cell-cell contacts in combination ...
Mnatsakanyan, Hayk; Sabater i Serra, Roser; Salmerón Sánchez, Manuel; Rico Tortosa, Patricia María(Frontiers Media SA, 2019-08-30)
[EN] Embryonic stem cells (ESCs) possess remarkable abilities, as they can differentiate into all cell types (pluripotency) and be self-renewing, giving rise to two identical cells. These characteristics make ESCs a powerful ...
[EN] Myogenic regeneration occurs through a chain of events beginning with the output of satellite cells from quiescent state, formation of competent myoblasts and later fusion and differentiation into myofibres. Traditionally, ...