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Mostrando ítems 1-20 de 20

A CANDLE for a deeper in-vivo insight

Coupé, Pierrick; Munz, Martin; Manjón Herrera, José Vicente; Ruthazer, Edward S.; Collins, D. Louis (Elsevier, 2012-05)

A new Collaborative Approach for eNhanced Denoising under Low-light Excitation (CANDLE) is introduced for the processing of 3D laser scanning multiphoton microscopy images. CANDLE is designed to be robust for low signal-to-noise ...
A computational psychiatry approach identifies how alpha-2A noradrenergic agonist Guanfacine affects feature-based reinforcement learning in the macaque

Hassani, S. A.; Oemisch, M.; Balcarras, M.; Westendorff, S.; Ardid-Ramírez, Joan Salvador; van der Meer, M. A.; Tiesinga, P.; Womelsdorf, T. (Nature Publishing Group, 2017-01-16)

[EN] Noradrenaline is believed to support cognitive flexibility through the alpha 2A noradrenergic receptor (a2A-NAR) acting in prefrontal cortex. Enhanced flexibility has been inferred from improved working memory with ...
Adaptive multiresolution non-local means filter for 3D magnetic resonance image denoising

Coupé ., Pierrick; Manjón Herrera, José Vicente; Robles Viejo, Monserrat; Collins ., Louis (Institution of Engineering and Technology (IET), 2012-07)

In this study, an adaptive multiresolution version of the blockwise non-local (NL)-means filter is presented for three-dimensional (3D) magnetic resonance (MR) images. On the basis of an adaptive soft wavelet coefficient ...
Anterior cingulate cortex cells identify process-specific errors of attentional control prior to transient prefrontal-cingulate inhibition

Shen, C.; Ardid-Ramírez, Joan Salvador; Kaping, D.; Westendorff, S.; Everling, S.; Womelsdorf, T. (Oxford University Press, 2015-08)

[EN] Errors indicate the need to adjust attention for improved future performance. Detecting errors is thus a fundamental step to adjust and control attention. These functions have been associated with the dorsal anterior ...
AssemblyNet: A large ensemble of CNNs for 3D whole brain MRI segmentation

Coupé, Pierrick; Mansencal, Boris; Clement, Michael; Giraud, Rémi; Denis de Senneville, Baudouin; Ta, Vinh-Thong; Lepetit, Vincent; Manjón Herrera, José Vicente (Elsevier, 2020-10-01)

[EN] Whole brain segmentation of fine-grained structures using deep learning (DL) is a very challenging task since the number of anatomical labels is very high compared to the number of available training images. To address ...
Attentional selection can be predicted by reinforcement learning of task-relevant stimulus features weighted by value-independent stickiness

Balcarras, M.; Ardid-Ramírez, Joan Salvador; Kaping, D.; Everling, S.; Womelsdorf, T. (MIT Press, 2016-02-01)

[EN] Attention includes processes that evaluate stimuli relevance, select the most relevant stimulus against less relevant stimuli, and bias choice behavior toward the selected information. It is not clear how these processes ...
BEaST: Brain extraction based on nonlocal segmentation technique

Eskildsen, Simon F.; Coupé, Pierrick; Fonov, Vladimir; Manjón Herrera, José Vicente; Leung, Kelvin K.; Guizard, Nicolas; Wassef, Shafik N.; Østergaard, Lasse Riis; Collins, D. Louis; Alzheimer's Dis Neuroimaging (Elsevier, 2012-02-01)

Brain extraction is an important step in the analysis of brain images. The variability in brain morphology and the difference in intensity characteristics due to imaging sequences make the development of a general purpose ...
Burst firing synchronizes prefrontal and anterior cingulate cortex during attentional control

Womelsdorf, T.; Ardid-Ramírez, Joan Salvador; Everling, S.; Valiante, T. (Elsevier, 2014-11-17)

[EN] Background: It is widely held that single cells in anterior cingulate and lateral prefrontal cortex (ACC/PFC) coordinate their activity during attentional processes, although cellular activity that may underlie such ...
Carbon monoxide effects on human ventricle action potential assessed by mathematical simulations

Trénor Gomis, Beatriz Ana; Cardona-Urrego, Karen Eliana; Saiz Rodríguez, Francisco Javier; Rajamani, Sridharan; Belardinelli, Luiz; Giles, Wayne R. (Frontiers Media, 2013-10)

Carbon monoxide (CO) that is produced in a number of different mammalian tissues is now known to have significant effects on the cardiovascular system. These include: (i) vasodilation, (ii) changes in heart rate and ...
Consensus statement from the first RdRp Summit: advancing RNA virus discovery at scale across communities

Charon, Justine; Olendraite, Ingrida; Forgia, Marco; Chong, Li Chuin; Hillary, Luke S.; Roux, Simon; Kupczok, Anne; Debat, Humberto; Sakaguchi, Shoichi; Tahzima, Rachid; Nakagawa, So; Babaian, Artem; Abroi, Aare; Bejerman, Nicolas; Ben Mansour, Karima; Cervera, A. (Frontiers Media, 2024-04-04)

[EN] Improved RNA virus understanding is critical to studying animal and plant health, and environmental processes. However, the continuous and rapid RNA virus evolution makes their identification and characterization ...
Feature-specific prediction errors and surprise across macaque fronto-striatal circuits

Oemisch, M.; Westendorff, S.; Azimi, Marzyeh; Hassani, Seyed Alireza; Ardid-Ramírez, Joan Salvador; Tiesinga, Paul; Womelsdorf, Thilo (Nature Publishing Group, 2019-01-11)

[EN] To adjust expectations efficiently, prediction errors need to be associated with the precise features that gave rise to the unexpected outcome, but this credit assignment may be problematic if stimuli differ on multiple ...
Hippocampal-amygdalo-ventricular atrophy score: Alzheimer disease detection using normative and pathological lifespan models

Coupé, Pierrick; Manjón Herrera, José Vicente; Mansencal, Boris; Tourdias, Thomas; Catheline, Gwenaelle; Planche, Vincent (John Wiley & Sons, 2022-07)

[EN] In this article, we present an innovative MRI-based method for Alzheimer disease (AD) detection and mild cognitive impairment (MCI) prognostic, using lifespan trajectories of brain structures. After a full screening ...
Lifespan Changes of the Human Brain In Alzheimer's Disease

Coupé, Pierrick; Manjón Herrera, José Vicente; Lanuza, Enrique; Catheline, Gwenaelle (Nature Publishing Group, 2019-03-08)

[EN] Brain imaging studies have shown that slow and progressive cerebral atrophy characterized the development of Alzheimer's Disease (AD). Despite a large number of studies dedicated to AD, key questions about the lifespan ...
Mapping of functionally characterized cell classes onto canonical circuit operations in primate prefrontal cortex

Ardid-Ramírez, Joan Salvador; Vinck, M.; Kaping, D.; Marquez, S.; Everling, S.; Womelsdorf, T. (Society for Neuroscience, 2015-02-18)

[EN] Microcircuits are composed of multiple cell classes that likely serve unique circuit operations. But how cell classes map onto circuit functions is largely unknown, particularly for primate prefrontal cortex during ...
Pro-arrhythmic Effects of Low Plasma [K+] in Human Ventricle: An Illustrated Review

Trénor Gomis, Beatriz Ana; Cardona-Urrego, Karen Eliana; Romero Pérez, Lucia; Gómez García, Juan Francisco; Saiz Rodríguez, Francisco Javier; Rajamani, Sridharan; Belardinelli, Luiz; Giles, Wayne (Elsevier, 2018)

[EN] Potassium levels in the plasma, [Kþ]o, are regulated precisely under physiological conditions. However, increases (from approx. 4.5 to 8.0 mM) can occur as a consequence of, e.g., endurance exercise, ischemic insult ...
Scoring by nonlocal image patch estimator for early detection of Alzheimer's disease

Coupé, Pierrick; Eskildsen, Simon F.; Manjón Herrera, José Vicente; Fonov, Vladirmir S.; Pruessner, Jens C.; Allard, Michèle; Collins, Louis D. (Elsevier, 2012)

Detection of Alzheimer's disease (AD) at the first stages of the pathology is an important task to accelerate the development of new therapies and improve treatment. Compared to AD detection, the prediction of AD using ...
Simultaneous segmentation and grading of anatomical structures for patient's classification: application to Alzheimer's Disease

Coupé, Pierrick; Eskildsen, Simon F.; Manjón Herrera, José Vicente; Fonov, Vladimir S.; Collins, D. Louis; Alzheimer's Dis Neuroimaging (Elsevier, 2012-02-15)

In this paper, we propose an innovative approach to robustly and accurately detect Alzheimer's disease (AD) based on the distinction of specific atrophic patterns of anatomical structures such as hippocampus (HC) and ...
Tissue-specific clocks in Arabidopsis show asymmetric coupling

Endo, Motomu; Shimizu, Hanako; Nohales, Maria A.; Araki, Takashi; Kay, Steve A. (Nature Publishing Group, 2014-10-29)

[EN] Many organisms rely on a circadian clock system to adapt to daily and seasonal environmental changes. The mammalian circadian clock consists of a central clock in the suprachiasmatic nucleus that is tightly coupled ...
Towards a Unified Analysis of Brain Maturation and Aging across the Entire Lifespan: A MRI Analysis

Coupé, Pierrick; Catheline, Gwenaelle; Lanuza, Enrique; Manjón Herrera, José Vicente (John Wiley & Sons, 2017-11)

[EN] There is no consensus in literature about lifespan brain maturation and senescence, mainly because previous lifespan studies have been performed on restricted age periods and/or with a limited number of scans, making ...
Viroid-like colonists of human microbiomes

Zheludev, Ivan N.; Edgar, Robert C.; Lopez-Galiano, Maria Jose; La Peña Del Rivero, Marcos De; Babaian, Artem; Bhatt, Ami S.; Fire, Andrew Z. (Elsevier, 2024-11-14)

[EN] Here, we describe "obelisks,"a class of heritable RNA elements sharing several properties: (1) apparently circular RNA 1 kb genome assemblies, (2) predicted rod-like genome-wide secondary structures, and (3) open ...