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El Páncreas Artificial: Control Automático de Infusión de Insulina en Diabetes Mellitus Tipo 1

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El Páncreas Artificial: Control Automático de Infusión de Insulina en Diabetes Mellitus Tipo 1

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dc.contributor.author Bondía Company, Jorge es_ES
dc.contributor.author Vehí, J. es_ES
dc.contributor.author Palerm, C. C. es_ES
dc.contributor.author Herrero, P. es_ES
dc.date.accessioned 2020-06-02T13:48:01Z
dc.date.available 2020-06-02T13:48:01Z
dc.date.issued 2010-04-09
dc.identifier.issn 1697-7912
dc.identifier.uri http://hdl.handle.net/10251/144994
dc.description.abstract [ES] La diabetes mellitus tipo 1 es una enfermedad crónica que afecta aproximadamente a 30 millones de personas en el mundo y se caracteriza por niveles de concentración de glucosa en sangre elevados producidos por una deficiencia absoluta de insulina. Ello produce numerosas complicaciones a largo plazo como retinopatía, nefropatía y neuropatía entre otras. Las terapias actuales basadas en el suministro de insulina exógena (por inyecciones o bomba de insulina), no consiguen normalizar los niveles de glucosa de forma eficiente. Los avances tecnológicos en la última década en sistemas de medición continua de glucosa e infusión de insulina, han impulsado el desarrollo del páncreas artificial, o control automático de infusión de insulina. En este trabajo se presentará, a modo de tutorial, el pasado, presente y futuro de esta tecnología, tan esperada por el paciente diabético. Se revisará el estado actual de la tecnología para la sensorización y actuación, principales desafíos desde el punto de vista de control, las diferentes ``escuelas'' y estudios clínicos del desempeño de controladores, así como herramientas de validación de controladores mediante simulación. Dada la complejidad del problema, el desarrollo del páncreas artificial será de forma escalonada, redundando progresivamente en la mejora de la calidad de vida del paciente. Los grandes avances en los últimos cinco años hacen preveer un horizonte cercano para la primera generación de páncreas artificial. es_ES
dc.description.abstract [EN] Type 1 diabetes mellitus is a chronic disease that affects approximately to 30 million people worldwide and is characterized by high blood glucose concentration levels produced by an absolute deficiency of insulin. That produces numerous long-term complications like retinopathy, nephropathy and neuropathy among others. Current therapies based on the exogenous delivery of insulin (through injections or an insulin pump), do not manage to normalize the glucose levels efficiently. Technological advances in the last decade in continuous glucose monitoring and insulin infusion have been a springboard for the development of the artificial pancreas, or automatic control of insulin infusion. In this work, the past, present and future of this technology, so long awaited by the diabetic patient, will be presented in the form of a tutorial. Current technology for sensorization and actuation will be reviewed, as well as main challenges from the control point of view, different “schools of thought” and clinical studies for controllers performance evaluation, and tools for the validation of controllers through simulation. Due to the complexity of the problem, the development of the artificial pancreas will be staggered, resulting progressively in an improvement of the patient’s quality of life. The big advances during last five years foresee a close horizon for a first generation of artificial pancreas. es_ES
dc.description.sponsorship Este trabajo ha sido realizado parcialmente gracias al apoyo del Ministerio de Ciencia e Innovación español, a través del proyecto DPI2007-66728-C02, de la Unión Europea a través de fondos FEDER y de la Wellcome Trust. es_ES
dc.language Español es_ES
dc.publisher Universitat Politècnica de València es_ES
dc.relation.ispartof Revista Iberoamericana de Automática e Informática industrial es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Biomedical systems es_ES
dc.subject Closed-loop control es_ES
dc.subject PID control es_ES
dc.subject Predictive control es_ES
dc.subject Physiological models es_ES
dc.subject Sistemas biomédicos es_ES
dc.subject Control en lazo cerrado es_ES
dc.subject Control PID es_ES
dc.subject Control predictivo es_ES
dc.subject Modelos fisiológicos es_ES
dc.subject.classification INGENIERIA DE SISTEMAS Y AUTOMATICA es_ES
dc.title El Páncreas Artificial: Control Automático de Infusión de Insulina en Diabetes Mellitus Tipo 1 es_ES
dc.title.alternative Artificial pancreas: automatic control of insulin infusion in type 1 diabetes mellitus es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/S1697-7912(10)70021-2
dc.relation.projectID info:eu-repo/grantAgreement/MEC//DPI2007-66728-C02-02/ES/CONTROL DE GLUCEMIA EN LAZO CERRADO EN PACIENTES CON DIABETES MELLITUS 1 Y PACIENTES CRITICOS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MEC//DPI2007-66728-C02-01/ES/CONTROL DE GLUCEMIA EN LAZO CERRADO EN PACIENTES CON DIABETES MELLITUS 1 Y PACIENTES CRITICOS/
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario de Automática e Informática Industrial - Institut Universitari d'Automàtica i Informàtica Industrial es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería de Sistemas y Automática - Departament d'Enginyeria de Sistemes i Automàtica es_ES
dc.description.bibliographicCitation Bondía Company, J.; Vehí, J.; Palerm, CC.; Herrero, P. (2010). El Páncreas Artificial: Control Automático de Infusión de Insulina en Diabetes Mellitus Tipo 1. Revista Iberoamericana de Automática e Informática industrial. 7(2):5-20. https://doi.org/10.1016/S1697-7912(10)70021-2 es_ES
dc.description.accrualMethod OJS es_ES
dc.relation.publisherversion https://doi.org/10.1016/S1697-7912(10)70021-2 es_ES
dc.description.upvformatpinicio 5 es_ES
dc.description.upvformatpfin 20 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 7 es_ES
dc.description.issue 2 es_ES
dc.identifier.eissn 1697-7920
dc.relation.pasarela OJS\8476 es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Wellcome Trust es_ES
dc.contributor.funder Ministerio de Educación y Ciencia es_ES
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