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Singlet oxygen production and in vitro phototoxicity studies on fenofibrate, mycophenolate mofetil, trifusal, and their active metabolites

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Singlet oxygen production and in vitro phototoxicity studies on fenofibrate, mycophenolate mofetil, trifusal, and their active metabolites

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Molins-Molina, O.; Bresolí-Obach, R.; García-Laínez, G.; Andreu Ros, MI.; Nonell, S.; Miranda Alonso, MÁ.; Jiménez Molero, MC. (2017). Singlet oxygen production and in vitro phototoxicity studies on fenofibrate, mycophenolate mofetil, trifusal, and their active metabolites. Journal of Physical Organic Chemistry. 30(9):1-7. https://doi.org/10.1002/poc.3722

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Título: Singlet oxygen production and in vitro phototoxicity studies on fenofibrate, mycophenolate mofetil, trifusal, and their active metabolites
Autor: Molins-Molina, Oscar Bresolí-Obach, Roger García-Laínez, G. Andreu Ros, María Inmaculada Nonell, Santiago Miranda Alonso, Miguel Ángel Jiménez Molero, María Consuelo
Entidad UPV: Universitat Politècnica de València. Departamento de Química - Departament de Química
Fecha difusión:
Resumen:
[EN] Singlet oxygen photosensitization (studied by time-resolved near-infrared emission spectroscopy) and in vitro phototoxicity (by means of the 3T3 neutral red uptake assay) have been investigated for the prodrugs ...[+]
Palabras clave: Neutral red uptake assay , Photosensitization , Phototoxicity , Singlet oxygen time-resolved near-infrared phosphorescence
Derechos de uso: Reserva de todos los derechos
Fuente:
Journal of Physical Organic Chemistry. (issn: 0894-3230 )
DOI: 10.1002/poc.3722
Editorial:
John Wiley & Sons
Versión del editor: https://doi.org/10.1002/poc.3722
Código del Proyecto:
info:eu-repo/grantAgreement/MINECO//CTQ2016-78875-P/ES/CONTROL SUPRAMOLECULAR DE LA FOTORREACTIVIDAD EN MEDIOS MICROHETEROGENOS BASADOS EN AMINOACIDOS: GELES MOLECULARES Y PROTEINAS TRANSPORTADORAS COMO NANORREACTORES./
...[+]
info:eu-repo/grantAgreement/MINECO//CTQ2016-78875-P/ES/CONTROL SUPRAMOLECULAR DE LA FOTORREACTIVIDAD EN MEDIOS MICROHETEROGENOS BASADOS EN AMINOACIDOS: GELES MOLECULARES Y PROTEINAS TRANSPORTADORAS COMO NANORREACTORES./
info:eu-repo/grantAgreement/MINECO//CTQ2013-47872-C2-1-P/ES/METABOLITOS FOTOACTIVOS/
info:eu-repo/grantAgreement/MINECO//CTQ2013-48767-C3-1-R/ES/DESARROLLO DE DISPOSITIVOS NANOESTRUCTURADOS COMO PLATAFORMAS MULTIMODALES FOTOTERAPEUTICAS. 1. QUIMICA/
info:eu-repo/grantAgreement/MINECO//CTQ2016-78454-C2-1-R/ES/ANTICUERPOS MONOCLONALES MODIFICADOS CON AGENTES FOTO- Y QUIMIOTERAPEUTICOS: CONJUGADOS TERNARIOS ACTIVABLES CON LUZ ROJA%2FNIR PARA USO TERAPEUTICO/
info:eu-repo/grantAgreement/Generalitat de Catalunya//2017 FI_B2 00140/
info:eu-repo/grantAgreement/MINECO//BES-2014-069404/ES/BES-2014-069404/
info:eu-repo/grantAgreement/MINECO//CTQ2015-71896-REDT/ES/RED DE FOTOQUIMICA BIOLOGICA/
info:eu-repo/grantAgreement/MINECO//PI16%2F01877/ES/Estrategia integrada de fotodiagnóstico combinando evaluación clínica, ensayos biológicos y estudios mecanísticos/
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Descripción: "This is the peer reviewed version of the following article: Molins-Molina, Oscar, Roger Bresolí-Obach, Guillermo Garcia-Lainez, Inmaculada Andreu, Santi Nonell, Miguel A. Miranda, and M. Consuelo Jiménez. 2017. Singlet Oxygen Production and in Vitro Phototoxicity Studies on Fenofibrate, Mycophenolate Mofetil, Trifusal, and Their Active Metabolites. Journal of Physical Organic Chemistry 30 (9). Wiley: e3722. doi:10.1002/poc.3722, which has been published in final form at https://doi.org/10.1002/poc.3722. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
Agradecimientos:
This work has been supported by grants CTQ-2013-47872C2-1-P, CTQ2016-78875-P, CTQ2013-48767-C3-1-R, CTQ2016-78454-C2-1-R, CTQ2015-71896-REDT, FIS PI16/01877, and BES-2014-069404 ( predoctoral fellowship to O. M.- M.) from ...[+]
Tipo: Artículo

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