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Functionalized inorganic nanoparticles used as labels in solid-phase immunoassays

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Functionalized inorganic nanoparticles used as labels in solid-phase immunoassays

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dc.contributor.author Cháfer Pericás, María Consuelo es_ES
dc.contributor.author Maquieira Catala, Ángel es_ES
dc.contributor.author Puchades, Rosa es_ES
dc.date.accessioned 2017-05-17T09:44:17Z
dc.date.available 2017-05-17T09:44:17Z
dc.date.issued 2012-01
dc.identifier.issn 0165-9936
dc.identifier.uri http://hdl.handle.net/10251/81268
dc.description.abstract [EN] In recent years, research has focused on the development of different types of inorganic nanoparticles (NPs) to be used as labels in immunoassays instead of fluorophores or organic particles. Basically, inorganic NPs are characterized by their optimal optical properties (e.g., high photostability and high quantum yield). The inorganic NPs studied most have been silica NPs, quantum dots (QDs), noble metals, metal nanoshells and lanthanide oxides. This review presents a general overview on the progress of NP-preparation methods and NP-surface-functionalization procedures, in order to improve the sensitivity of the immunoassays involved. Other factors that must be taken into account are the type of solid-phase substrate (e.g., NP, microtiter plate, membrane and cover glass), format (i.e. direct or indirect) and the detection mode employed in the assay. Fluorescence has been used most as the detection mode. Also widely used has been time-resolved fluorescence with lanthanide ions as probes. Finally, our review of recent literature showed that most published immunoassays using inorganic NPs were applied to biological samples. (C) 2011 Elsevier Ltd. All rights reserved. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Trends in Analytical Chemistry es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Fluorescence detection es_ES
dc.subject Functionalized inorganic nanoparticle es_ES
dc.subject Immunoassay es_ES
dc.subject Labeling es_ES
dc.subject Lanthanide-ion probe es_ES
dc.subject Nanoparticle es_ES
dc.subject Nanoparticle preparation es_ES
dc.subject Solid-phase immunoassay es_ES
dc.subject Solid-phase substrate es_ES
dc.subject Surface functionalization es_ES
dc.subject Functionalized es_ES
dc.subject Solid-phase es_ES
dc.subject Fluorescence es_ES
dc.subject Immunology es_ES
dc.subject Optical properties es_ES
dc.subject Precious metals es_ES
dc.subject Quantum yield es_ES
dc.subject Rare earth elements es_ES
dc.subject Semiconductor quantum dots es_ES
dc.subject Silica es_ES
dc.subject Nanoparticles es_ES
dc.subject Europium oxide es_ES
dc.subject Fluorescein isothiocyanate es_ES
dc.subject Inorganic nanoparticle es_ES
dc.subject Lanthanide oxide es_ES
dc.subject Magnetic nanoparticle es_ES
dc.subject Metal oxide es_ES
dc.subject Nanoshell es_ES
dc.subject Quantum dot es_ES
dc.subject Silica nanoparticle es_ES
dc.subject Unclassified drug es_ES
dc.subject Antibody labeling es_ES
dc.subject Biocompatibility es_ES
dc.subject Chemical procedures es_ES
dc.subject Chemoluminescence es_ES
dc.subject Competitive immunoassay es_ES
dc.subject Conjugation es_ES
dc.subject Electrochemistry es_ES
dc.subject Flame spray pyrolysis es_ES
dc.subject Fluorescence analysis es_ES
dc.subject Histochemistry es_ES
dc.subject Human es_ES
dc.subject Hydrolysis es_ES
dc.subject Limit of detection es_ES
dc.subject Non competitive immunoassay es_ES
dc.subject Nonhuman es_ES
dc.subject Polymerization es_ES
dc.subject Priority journal es_ES
dc.subject Pyrolysis es_ES
dc.subject Raman spectrometry es_ES
dc.subject Review es_ES
dc.subject Sample es_ES
dc.subject Solid phase immunoassay es_ES
dc.subject Surface plasmon resonance es_ES
dc.subject Synthesis es_ES
dc.subject Ultrasound es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.title Functionalized inorganic nanoparticles used as labels in solid-phase immunoassays es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.trac.2011.07.011
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.description.bibliographicCitation Cháfer Pericás, MC.; Maquieira Catala, Á.; Puchades, R. (2012). Functionalized inorganic nanoparticles used as labels in solid-phase immunoassays. Trends in Analytical Chemistry. 31:144-156. doi:10.1016/j.trac.2011.07.011 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.1016/j.trac.2011.07.011 es_ES
dc.description.upvformatpinicio 144 es_ES
dc.description.upvformatpfin 156 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 31 es_ES
dc.relation.senia 212778 es_ES


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