Aparici-Espert, Maria Isabel; Francés Monerris, Antonio; Rodríguez Muñiz, Gemma María; Roca Sanjuan, Daniel; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel(American Chemical Society, 2016-05-20)
The chemical fate of radical intermediates is relevant to understand the biological effects of radiation and to explain formation of DNA lesions. A direct approach to selectively generate the putative reactive intermediates ...
Reid, Lara O.; Castaño, Carolina; Dantola, M L.; Lhiaubet ., Virginie Lyria; Miranda Alonso, Miguel Ángel; Marín García, Mª Luisa; Thomas, A. H.(Elsevier, 2017)
[EN] Oxidative damage to proteins leads to a variety of modifications that are markers of pathogenesis. One of the most important modifications is the dityrosine (Tyr(2)) cross-link, resulting from an oxidative covalent ...
Marín García, Mª Luisa; Lhiaubet, Virginie Lyria; Santos-Juanes Jordá, Lucas; Soler Escoda, Juan Miguel; Gomis Vicens, Juan; Arques Sanz, Antonio; Amat Payá, Ana María; Miranda Alonso, Miguel Ángel(Elsevier, 2011-03-14)
[EN] The role of hydroxyl radical in different solar photocatalytic processes, namely photo-Fenton, titanium dioxide-based oxidation and organic photocatalysis (triphenylpyrylium) has been investigated. Using a methodology ...
Cuquerella Alabort, Maria Consuelo; Lhiaubet ., Virginie Lyria; Cadet, Jean; Miranda Alonso, Miguel Ángel(American Chemical Society, 2012)
[EN] A lthough the carcinogenic potential of ultraviolet radiation is well-known, UV light may interact with DNA by direct absorption or through photosensitization by endogenous or exogenous chromophores. These chromophores ...
Lammers, Ivonne; Lhiaubet, Virginie Lyria; Freek, Ariese; Miranda Alonso, Miguel Ángel; Gooijer, Cees(Elsevier, 2013-03-15)
The interaction of the enantiomers of the non-steroidal anti-inflammatory drug naproxen (NPX) with
human serum albumin (HSA) has been investigated using fluorescence and phosphorescence spectroscopy
in the steady-state ...
Vendrell Criado, Victoria; Lhiaubet, Virginie Lyria; Yamaji, Minoru; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel(Royal Society of Chemistry, 2016)
The efficiency of thymine (Thy) and uracil (Ura) to form cyclobutane pyrimidine dimers (CPDs) in solution, upon UV irradiation differs by one order of magnitude. This could to be partially related to the steric hindrance ...
Reid, Lara O.; Dántola, M. Laura; Petroselli, Gabriela; Erra-Balsells, Rosa; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria; Thomas, Andrés H.(American Chemical Society, 2019-11)
[EN] The main goal of the present work was to investigate the damages photoinduced by pterin (Ptr), an endogenous photosensitizer present in human skin under pathological conditions, on a globular protein such as ubiquitin ...
Cuquerella Alabort, Maria Consuelo; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel; Bosca Mayans, Francisco(The Royal Society of Chemistry, 2017)
[EN] The crucial role of photosensitizer@DNA complexation in the formation of cyclobutane pyrimidine dimers (CPDs) has been demonstrated using femtosecond and nanosecond transient absorption and emission measurements in ...
Li, Ming-De; Yan, Zhiping; Zhu, Ruixue; Phillips,David Lee; Aparici-Espert, Maria Isabel; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel(John Wiley & Sons, 2018-05-02)
[EN] Imatinib is a synthetic tyrosinase inhibitor that is employed for the treatment of some kinds of human cancer. This drug has a low phototoxicity towards DNA, but its pyridylpyrimidine (1) fragment by itself exhibits ...
Marín Melchor, Mireia; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel(American Chemical Society, 2012)
Photocyclization of N-methyldiphenylamine to N-methylcarbazole is achieved within the microenvironment provided by site I of serum albumins.
Quantum yield determinations, combined with transient absorption spectroscopic ...
Fraga-Timiraos, Ana Belén; Francés-Monerris, Antonio; Rodríguez Muñiz, Gemma María; Navarrete-Miguel, Miriam; Miranda Alonso, Miguel Ángel; Roca Sanjuan, Daniel; Lhiaubet, Virginie Lyria(John Wiley & Sons, 2018-10-12)
[EN] Azetidines are interesting compounds in medicine and chemistry as bioactive scaffolds and synthetic intermediates. However, photochemical processes involved in the generation and fate of azetidine-derived radical ions ...
Nardi, Giacomo; Marín García, Mª Luisa; de Souza, Pierre A.; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel(The Royal Society of Chemistry, 2014)
[EN] The photochemical properties of itraconazole (1), a broad-spectrum antifungal agent, have been investigated in connection with reported skin photosensitivity disorders. Steady state photolysis, fluorescence and ...
Nardi, Giacomo(Universitat Politècnica de València, 2015-03-31)
Photosensitizing effects of xenobiotics are of increasing concern in public health
since modern lifestyle often associates sunlight exposure with the presence of chemical
substances in the skin. An important number of ...
Fraga Timiraos, Ana Belén(Universitat Politècnica de València, 2019-03-04)
[ES] La radiación ultravioleta está asociada a la formación de ciertas lesiones en el ADN que están en el origen del cáncer de piel. Entre las más relevantes se encuentran los daños que se producen en las bases pirimidínicas: ...
Aparici-Espert, Maria Isabel; García-Laínez, G.; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria(American Chemical Society, 2018-03)
[EN] In this work, the attention is focused on UVA-photosensitized reactions triggered by a DNA chromophore-containing lesion, namely 5-formyluracil. This is a major oxidatively generated lesion that exhibits an enhanced ...
Aparici-Espert, Maria Isabel; Cuquerella Alabort, Maria Consuelo; Paris, Cecilia; Lhiaubet ., Virginie Lyria; Miranda Alonso, Miguel Ángel(The Royal Society of Chemistry, 2016)
[EN] Using a sunscreen-based photocage, we have demonstrated that it is possible to prevent photodegradation of a bioactive compound and to achieve its controlled photorelease. The concept has been proven linking avobenzone, ...
Marín Melchor, Mireia; Lhiaubet, Virginie Lyria; PARIS, CECILIA GERTRUDIS; Yamaji, Minoru; Miranda Alonso, Miguel Ángel(Royal Society of Chemistry, 2011)
In the present work, three dibenzoylmethane derivatives in their beta-diketo form have been selected to investigate their photophysical and photochemical behavior upon interaction with human serum albumin (HSA). In organic ...
[EN] The photochemistry of the DNA biomacromolecule is an issue of paramount importance as it is part of the etiology of skin cancer development, being ultraviolet sunlight radiation the most relevant environmental carcinogen. ...
Aparici Espert, María Isabel(Universitat Politècnica de València, 2018-07-13)
El objetivo principal de esta tesis es contrastar el papel de dichos compuestos 1,3-dicarbonilicos como agentes que dañan el ADN con respecto a su potencial fotoprotector.
Primero, 5,6-dihidropirimidinas han sido ...
Pinero Santiago, Luis; Garcia, Carmelo; Lhiaubet, Virginie Lyria; Trzcionka, Jéròme; Oyola, Rolando; Torres, Karen; Leguillu, Jaysika; Miranda Alonso, Miguel Ángel(Royal Society of Chemistry, 2013-11)
Unwanted photoinduced responses are well-known adverse effects of most promazine drugs, including levomepromazine (LPZ, Levoprome((R)) or Nozinan((R))). This drug is indicated in psychiatry primarily for the treatment of ...