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Browsing by Author "Lhiaubet, Virginie Lyria"

Now showing items 1-20 of 34

A Combined Experimental and Theoretical Approach to the Photogeneration of 5,6-Dihydropyrimidin-5-yl Radicals in Nonaqueous Media

Aparici-Espert, Maria Isabel; Francés Monerris, Antonio; Rodríguez Muñiz, Gemma María; Roca Sanjuan, Daniel; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel (American Chemical Society, 2016-05-20)

The chemical fate of radical intermediates is relevant to understand the biological effects of radiation and to explain formation of DNA lesions. A direct approach to selectively generate the putative reactive intermediates ...
A novel synthetic approach to tyrosine dimers based on pterin photosensitization

Reid, Lara O.; Castaño, Carolina; Dantola, M L.; Lhiaubet ., Virginie Lyria; Miranda Alonso, Miguel Ángel; Marín García, Mª Luisa; Thomas, A. H. (Elsevier, 2017)

[EN] Oxidative damage to proteins leads to a variety of modifications that are markers of pathogenesis. One of the most important modifications is the dityrosine (Tyr(2)) cross-link, resulting from an oxidative covalent ...
A photophysical approach to investigate the photooxidation mechanism of pesticides: Hydroxyl radical versus electron transfer

Marín García, Mª Luisa; Lhiaubet, Virginie Lyria; Santos-Juanes Jordá, Lucas; Soler Escoda, Juan Miguel; Gomis Vicens, Juan; Arques Sanz, Antonio; Amat Payá, Ana María; Miranda Alonso, Miguel Ángel (Elsevier, 2011-03-14)

[EN] The role of hydroxyl radical in different solar photocatalytic processes, namely photo-Fenton, titanium dioxide-based oxidation and organic photocatalysis (triphenylpyrylium) has been investigated. Using a methodology ...
Benzophenone photosensitized DNA damage

Cuquerella Alabort, Maria Consuelo; Lhiaubet ., Virginie Lyria; Cadet, Jean; Miranda Alonso, Miguel Ángel (American Chemical Society, 2012)

[EN] A lthough the carcinogenic potential of ultraviolet radiation is well-known, UV light may interact with DNA by direct absorption or through photosensitization by endogenous or exogenous chromophores. These chromophores ...
Binding of naproxen enantiomers to human serum albumin studied by fluorescence and room-temperature phosphorescence

Lammers, Ivonne; Lhiaubet, Virginie Lyria; Freek, Ariese; Miranda Alonso, Miguel Ángel; Gooijer, Cees (Elsevier, 2013-03-15)

The interaction of the enantiomers of the non-steroidal anti-inflammatory drug naproxen (NPX) with human serum albumin (HSA) has been investigated using fluorescence and phosphorescence spectroscopy in the steady-state ...
Blocking cyclobutane pyrimidine dimer formation by steric hindrance

Vendrell Criado, Victoria; Lhiaubet, Virginie Lyria; Yamaji, Minoru; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel (Royal Society of Chemistry, 2016)

The efficiency of thymine (Thy) and uracil (Ura) to form cyclobutane pyrimidine dimers (CPDs) in solution, upon UV irradiation differs by one order of magnitude. This could to be partially related to the steric hindrance ...
Drug-DNA complexation as the key factor in photosensitized thymine dimerization

Cuquerella Alabort, Maria Consuelo; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel; Bosca Mayans, Francisco (The Royal Society of Chemistry, 2017)

[EN] The crucial role of photosensitizer@DNA complexation in the formation of cyclobutane pyrimidine dimers (CPDs) has been demonstrated using femtosecond and nanosecond transient absorption and emission measurements in ...
Enhanced Drug Photosafety by Interchromophoric Interaction Due to Intramolecular Charge Separation

Li, Ming-De; Yan, Zhiping; Zhu, Ruixue; Phillips,David Lee; Aparici-Espert, Maria Isabel; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel (John Wiley & Sons, 2018-05-02)

[EN] Imatinib is a synthetic tyrosinase inhibitor that is employed for the treatment of some kinds of human cancer. This drug has a low phototoxicity towards DNA, but its pyridylpyrimidine (1) fragment by itself exhibits ...
Enhanced photochemical [6pi] electrocyclization within the lipophilic protein binding site

Marín Melchor, Mireia; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel (American Chemical Society, 2012)

Photocyclization of N-methyldiphenylamine to N-methylcarbazole is achieved within the microenvironment provided by site I of serum albumins. Quantum yield determinations, combined with transient absorption spectroscopic ...
Generation of reactive aryl radical intermediates in the reductive photodehalogenation of itraconazole

Nardi, Giacomo; Marín García, Mª Luisa; de Souza, Pierre A.; Lhiaubet, Virginie Lyria; Miranda Alonso, Miguel Ángel (The Royal Society of Chemistry, 2014)

[EN] The photochemical properties of itraconazole (1), a broad-spectrum antifungal agent, have been investigated in connection with reported skin photosensitivity disorders. Steady state photolysis, fluorescence and ...
MECHANISTIC STUDIES ON THE PHOTOTOXICITY OF ROSUVASTATIN, ITRACONAZOLE AND IMATINIB

Nardi, Giacomo (2015-03-31)

Photosensitizing effects of xenobiotics are of increasing concern in public health since modern lifestyle often associates sunlight exposure with the presence of chemical substances in the skin. An important number of ...
Model Studies on the Photorepair of (6-4) Dimeric Lesions of DNA

Fraga Timiraos, Ana Belén (2019-03-04)

[ES] La radiación ultravioleta está asociada a la formación de ciertas lesiones en el ADN que están en el origen del cáncer de piel. Entre las más relevantes se encuentran los daños que se producen en las bases pirimidínicas: ...
Oxidatively Generated Lesions as Internal Photosensitizers for Pyrimidine Dimerization in DNA

Aparici-Espert, Maria Isabel; García-Laínez, G.; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria (American Chemical Society, 2018-03)

[EN] In this work, the attention is focused on UVA-photosensitized reactions triggered by a DNA chromophore-containing lesion, namely 5-formyluracil. This is a major oxidatively generated lesion that exhibits an enhanced ...
Photocages for protection and controlled release of bioactive compounds

Aparici-Espert, Maria Isabel; Cuquerella Alabort, Maria Consuelo; Paris, Cecilia; Lhiaubet ., Virginie Lyria; Miranda Alonso, Miguel Ángel (The Royal Society of Chemistry, 2016)

[EN] Using a sunscreen-based photocage, we have demonstrated that it is possible to prevent photodegradation of a bioactive compound and to achieve its controlled photorelease. The concept has been proven linking avobenzone, ...
Photochemical and photophysical properties of dibenzoylmethane derivatives within protein

Marín Melchor, Mireia; Lhiaubet, Virginie Lyria; PARIS, CECILIA GERTRUDIS; Yamaji, Minoru; Miranda Alonso, Miguel Ángel (Royal Society of Chemistry, 2011)

In the present work, three dibenzoylmethane derivatives in their beta-diketo form have been selected to investigate their photophysical and photochemical behavior upon interaction with human serum albumin (HSA). In organic ...
Photochemistry of 1,3-Dicarbonyl Compounds: DNA Photodamage vs. Photoprotection

Aparici Espert, María Isabel (2018-07-13)

El objetivo principal de esta tesis es contrastar el papel de dichos compuestos 1,3-dicarbonilicos como agentes que dañan el ADN con respecto a su potencial fotoprotector. Primero, 5,6-dihidropirimidinas han sido ...
Photooxidation mechanism of levomepromazine in different solvents

Pinero Santiago, Luis; Garcia, Carmelo; Lhiaubet, Virginie Lyria; Trzcionka, Jéròme; Oyola, Rolando; Torres, Karen; Leguillu, Jaysika; Miranda Alonso, Miguel Ángel (Royal Society of Chemistry, 2013-11)

Unwanted photoinduced responses are well-known adverse effects of most promazine drugs, including levomepromazine (LPZ, Levoprome((R)) or Nozinan((R))). This drug is indicated in psychiatry primarily for the treatment of ...
Photophysical properties of 5-substituted 2-thiopyrimidines

Vendrell Criado, Victoria; Sáez Cases, José Antonio; Lhiaubet, Virginie Lyria; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel (Royal Society of Chemistry, 2013)

The aim of the present work is to determine the influence of C5 substitution on the photophysical properties of 2-thiopyrimidines (2-TPyr). For this purpose, 2-thiouracil, 5-t-butyl-2-thiouracil and 2-thiothymine (TU, BTU ...
Photophysics and photochemistry of the beta-lapachone derived diphenyldihydrodioxin: generation and characterization of its cation radical

Netto Ferreira, Jose Carlos; Lhiaubet ., Virginie Lyria; Bernades, Bauer; Ferreira, Aurelio Baird Buarque; Miranda Alonso, Miguel Ángel (The Royal Society of Chemistry, 2014)

[EN] The photophysics and photochemistry of the beta-lapachone derived diphenyldihydrodioxin 3 were investigated using steady-state and time resolved techniques. Laser excitation of 3 leads to the formation of its cation ...
Photosensitised pyrimidine dimerisation in DNA

Bosca Mayans, Francisco; Lhiaubet, Virginie Lyria; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel (Royal Society of Chemistry, 2011)

Triplet-mediated pyrimidine (Pyr) dimerisation is a key process in photochemical damage to DNA. It may occur in the presence of a photosensitiser, provided that a number of requirements are fulfilled, such as favourable ...