Vivo Llorca, Gema(Universitat Politècnica de València, 2017-10-25)
The aim of this project is to optimize a novel nanodispositive based on silica mesoporous nanoparticles (MSNs) for genome editing in human cell lines, using CRISPR/Cas9 technology. It focuses on the synthesis and ...
Alfonso Almazán, José Manuel(Universitat Politècnica de València, 2015-01-21)
[ES] El
cáncer
de
ovario
epitelial
es
la
quinta
causa
de
muerte
en
las
mujeres
en
el
mundo
occidental
y
la
primera
por
cáncer
ginecológico.
Se
trata
de
una
enfermedad
heterogénea
con
una
t ...
López Toboso, Yolanda(Universitat Politècnica de València, 2018-10-23)
Los pacientes con VIH muestran una alta prevalencia de infección anal por VPH de alto riesgo y una incidencia muy aumentada de lesiones precancerosas anales y cáncer anal. La infección por VIH se asocia también a disbiosis ...
Roig Pons, Marta(Universitat Politècnica de València, 2014-10-24)
[EN] The aim of this study was the evaluation of cytotoxicity, pro-inflammatory potential and oxidative
stress in human airway cells, produced by nanoparticles of different origins: metallic nanoparticles
generated in ...
Climent Terol, Estela; Mondragón Martínez, Laura; Martínez Mañez, Ramón; Sancenón Galarza, Félix; Marcos Martínez, María Dolores; Murguía Ibáñez, José Ramón; Amoros del Toro, Pedro Jose; Rurack, Knut; Pérez Payá, Enrique(Wiley-VCH Verlag, 2013-07-10)
The coupling of gated-indicator delivery with highly specific biochemical recognition is an innovative strategy for the detection of DNA sequences, able to compete with classical methods which need PCR amplification, in ...
[DE] Mit DNA verschlossene und mit Farbstoff beladene mesoporöse Siliciumdioxid-Nanopartikel wurden zum Nachweis von Mycoplasma bis zu einer Nachweisgrenze von ca. 70 genomischen DNA-Kopien pro mu-L in real kontaminierten ...
Mellado Gómez, Esther(Universitat Politècnica de València, 2016-06-30)
[EN] Single-cell genomics involves novel technologies that allow the isolation and analysis of the limited genetic material present within a single cell, providing scope for gene expression studies at the single-cell level. ...
Jordá Fernández, Celia Rosa(Universitat Politècnica de València, 2022-10-03)
[ES] Este proyecto se basa en la síntesis y caracterización de nanopartículas (NP) con propiedades antimicrobianas. Las NP se prepararán a partir de sílice porosa (MCM-41) con una elevada porosidad capaz de encapsular ...
Rodríguez Hernández, Carlos Javier; Llorens Agost, M.; Calbó, J.; Murguía, Jose R.; Guinovart, J.J.(Wiley, 2013-05-21)
[EN] Both radiotherapy and most effective chemotherapeutic agents induce different types of DNA damage. Here we show that tungstate modulates cell response to DNA damaging agents. Cells treated with tungstate were more ...
Serrano Martín, María Dolores(Universitat Politècnica de València, 2020-05-05)
[EN] Mog1 was first described as a Gsp1-binding protein involved in nuclear protein import both in humans and yeast, being Gsp1 the homologue of the human Ran-GTPase. Later, it was found that human Mog1 also regulates the ...
Gorbe, Mónica; Barba Bon, Andrea; De la Torre, Cristina; Gil Grau, Salvador; Costero Nieto, Ana María; Sancenón Galarza, Félix; Murguía, Jose R.; Martínez-Máñez, Ramón(Wiley-VCH Verlag, 2015-10)
A new photosensitizer (1) based on the 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) scaffold has been synthesized. 1 is water soluble and showed an intense
absorption band at 490 nm (e=77600 cm-1M-1) and an emission ...
[EN] Learning to let go with age: Intracellular controlled release of molecules within senescent cells was achieved using mesoporous silica nanoparticles (MSNs) capped with a galacto-oligosaccharide (GOS) to contain the ...
García-Fernández, Alba; García-Laínez, G.; Ferrandiz Manglano, Mª Luisa; Aznar, Elena; Sancenón Galarza, Félix; Alcaraz, Mª Jose; Murguía, Jose R.; Marcos Martínez, María Dolores; Martínez-Máñez, Ramón; Costero, Ana M.; Orzaez, Mar(Elsevier, 2017)
[EN] Acute inflammation is a protective response of the body to harmful stimuli, such as pathogens or damaged cells. However, dysregulated inflammation can cause secondary damage and could thus contribute to the pathophysiology ...
Ultimo, Amelia; Giménez Morales, Cristina; BARTOVSKY, PAVEL; Aznar, Elena; Sancenón Galarza, Félix; Marcos Martínez, María Dolores; Amoros del Toro, Pedro Jose; Bernardo, Ana R.; Martínez-Máñez, Ramón; Jiménez Lara, Ana M.; Murguía, Jose R.(Wiley, 2016-01-26)
The authors describe herein a Toll-like receptor 3 (TLR3) targeting delivery system based on mesoporous silica nanoparticles capped with the synthetic double stranded RNA polyinosinic-polycytidylic acid (poly(I:C)) for ...
Tejada Colón, Ana(Universitat Politècnica de València, 2019-07-31)
[ES] La expresión génica en eucariotas es un proceso complejo que comprende diferentes etapas interconectadas, incluyendo la modificación de la cromatina, la transcripción y el procesamiento, exportación al citoplasma, ...
Bhat, Ravishankar; Ribes, Àngela; Mas Font, Nuria; Aznar, Elena; Sancenón Galarza, Félix; Marcos Martínez, María Dolores; Murguía, Jose R.; Venkataraman, A.; Martínez-Máñez, Ramón(American Chemical Society, 2016)
[EN] The possibility of achieving sophisticated actions in complex biological environments using gated nanoparticles is an exciting prospect with much potential. We herein describe new gated mesoporous silica nanoparticles ...
Díez, Paula; Sanchez, Alfredo; Gamella, María; Paloma Martinez-Ruiz; Aznar, Elena; De La Torre, Cristina; Murguía, Jose R.; Martínez-Máñez, Ramón; Villalonga, Reynaldo; Pingarrón, J.M.(American Chemical Society, 2014)
We report herein the design of a smart delivery system in
which cargo delivery from capped mesoporous silica (MS) nanoparticles is
controlled by an integrated enzyme-based control unit . The system consists
of Janus-type ...
Cárcel Pérez, María(Universitat Politècnica de València, 2015-09-08)
[EN] The project consist in using a camera which is able to control and regulate the environmental oxygen concentration. This is possible thanks to a software that has been specifically designed to study the influence of ...