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Browsing by Author "Lebourg, Myriam Annette Madeleine"

Now showing items 1-19 of 19

Biomateriales poliméricos flexibles para fusiones vertebrales

Primo Capella, Victor; Lara Sáez, Irene; Avila Carrasco, Carolina; Montaner Murgui, Celia; Lebourg ., Myriam Madeleine; Ródenas Rochina, Joaquín; Garagorri Ganchegui, Nerea; Bresó Peris, Magdalena; Atienza Vicente, Carlos Manuel (Universitat Politècnica de València. Instituto de Biomecánica de Valencia, 2011-06)

[EN] In the framework of the CENIT INTELIMPLANT, the consortium composed by TEQUIR, S.L., the Instituto de Biomecánica (IBV) and other regional and nacional research groups have carried out the development, ...
Biomimetic hydroxyapatite coating on pore walls improves osteointegration of poly(L-lactic acid) scaffolds

Deplaine, Harmony; Lebourg, Myriam Madeleine; Ripalda, P; Vidaurre Garayo, Ana Jesús; Sanz-Ramos, Patricia; Mora, Gonzalo; Prósper, Felipe; Ochoa, I.; Doblare Castellano, Manuel; Gómez Ribelles, José Luís; IZAL AZCARATE, IÑIGO; Gallego-Ferrer, Gloria (Wiley, 2013-01)

[EN] Polymer ceramic composites obtained as the result of a mineralization process hold great promise for the future of tissue engineering. Simulated body fluids (SBFs) are widely used for the mineralization of polymer ...
Cell-free cartilage engineering approach using hyaluronic acid-polycaprolactone scaffolds: A study invivo

Lebourg, Myriam Madeleine; Martínez Díaz, S.; Garcia Giralt, Natalia; Torres Claramunt, R.; Gómez-Tejedor, José Antonio; Gómez Ribelles, José Luís; Vila Canet, G; Monllau, J.C. (SAGE Publications (UK and US), 2014-05)

Polycaprolactone scaffolds modified with cross-linked hyaluronic acid were prepared in order to establish whether a more hydrophilic and biomimetic microenvironment benefits the progenitor cells arriving from bone marrow ...
Chondrocytes cultured in an adhesive macroporous scaffold subjected to stirred flow bioreactor behave like in static culture

Gamboa Martínez, Tatiana Carolina; Ródenas Rochina, Joaquín; Rico Tortosa, Patricia María; Lebourg, Myriam Madeleine; Gómez Ribelles, José Luís; Salmerón Sánchez, Manuel; Gallego-Ferrer, Gloria (American Scientific Publishers, 2013)

[EN] The aim of this study was to evaluate whether mechanical stimulation helps to modulate the redifferentiation of human chondrocytes on adhesive 3D substrates. In a previous work, it was shown that chondrocytes seeded ...
Compositional changes to synthetic biodegradable scaffolds modulate the influence of hydrostatic pressure on chondrogenesis of mesenchymal stem cells

Ródenas Rochina, Joaquín; Kelly, Daniel John; Gómez Ribelles, José Luís; Lebourg, Myriam Madeleine (IOP Publishing, 2016)

[EN] Mechanical cues such as hydrostatic pressure (HP) are known to regulate mesenchymal stem cell (MSC) differentiation. The fate of such cells is also strongly influenced by their substrate. The objective of this study ...
Desarrollo y caracterización de un scaffold para ingeniería tisular de hueso

Ródenas Rochina, Joaquín (Universitat Politècnica de València, 2011-09-21)

En este trabajo, se desarrollaron series de scaffolds basados en PCL con refuerzo de hidroxiapatita y Bioglass para evaluar cual es mejor para ingenieria tisular osea. Se midieron las propedades fisicas (comportamiento ...
Different hyaluronic acid morphology modulates primary articular chondrocyte behaviour in hyaluronic acid coated polycaprolactone scaffolds

Lebourg, Myriam Madeleine; Ródenas Rochina, Joaquín; Sousa, Tiago; Mano, Joao; Gómez Ribelles, José Luís (Wiley, 2013-02)

Scaffolds for cartilage tissue engineering should promote both adequate biomechanical environment and chondrogenic stimulation. Hyaluronic acid (HA) has been used in cartilage engineering for its chondrogenic and ...
Dorsal and Ventral Stimuli in Cell-Material Interactions: Effecton Cell Morphology

Ballester Beltrán, José; Lebourg, Myriam Madeleine; Rico Tortosa, Patricia María; Salmerón Sánchez, Manuel (American Vacuum Society, 2012-06)

Cells behave differently between bidimensional (2D) and tridimensional (3D) environments. While most of the in vitro cultures are 2D, most of the in vivo extracellular matrices are 3D, which encourages the development of ...
Dorsal and ventral stimuli in sandwich-like microenvironments. Effect on cell differentiation

Ballester Beltrán, José; Lebourg, Myriam Madeleine; Salmerón Sánchez, Manuel (Wiley, 2013-06-27)

While most of the in vivo extracellular matrices are 3D, most of the in vitro cultures are 2D--where only ventral adhesion is permitted--thus modifying cell behavior as a way to self-adaptation to this unnatural environment. ...
Effect of the physicochemical properties of pure chitosan-coated poly(lactic acid) scaffolds on the chondrogenic differentiation of mesenchymal stem cells from osteoarthritic patients

Magalhaes, Joana; Lebourg, Myriam Madeleine; Deplaine, Harmony; Gómez Ribelles, José Luís; Blanco, Francisco J. (Mary Ann Liebert, 2015-02-01)

Due to the attractive properties of poly(L-lactic acid) (PLLA) and chitosan (CHT) for tissue engineering applications, this study is aimed at analyzing the chondrogenic potential of human bone marrow-derived mesenchymal ...
Effect of topological cues on material-driven fibronectinfibrillogenesis and cell differentiation

Ballester Beltrán, José; Cantini, Marco; Lebourg, Myriam Madeleine; Rico Tortosa, Patricia María; Moratal Pérez, David; García, Andrés J.; Salmerón Sánchez, Manuel (Springer Verlag (Germany), 2012-01)

[EN] Fibronectin (FN) assembles into fibrillar networks by cells through an integrin-dependent mechanism. We have recently shown that simple FN adsorption onto poly(ethyl acrylate) surfaces (PEA), but not control polymer ...
Effects of hydroxyapatite filler on long-term hydrolytic degradation of PLLA/PCL

Ródenas Rochina, Joaquín; Vidaurre, Ana; Castilla Cortázar, María Isabel Cecilia; Lebourg ., Myriam Madeleine (Elsevier, 2015)

[EN] Poly(L-lactic acid)(PLLA)/poly(epsilon-caprolactone)(PCL)/hydroxyapatite(HAp) composites appear as promising materials for healing large bone defects. Highly porous PLLA/PCL scaffolds, 80/20, 20/80 weight ratios, ...
Fibronectin-matrix sandwich-like microenvironments to manipulate cell fate

Ballester Beltrán, José; Moratal Pérez, David; Lebourg, Myriam Madeleine; Salmerón Sánchez, Manuel (Royal Society of Chemistry, 2014)

[EN] Conventional 2D substrates fail to represent the natural environment of cells surrounded by the 3D extracellular matrix (ECM). We have proposed sandwich-like microenvironments as a versatile tool to study cell behaviour ...
Hydrolytic degradation of PLLA/PCL microporous membranes prepared by freeze extraction

Gaona, Luis Andrés; Gómez Ribelles, José Luís; Perilla, Jairo Ernesto; Lebourg, Myriam Madeleine (Elsevier, 2012-09)

Poly(L-lactic acid) Poly(e-caprolactone) blends (PLLA/PCL) porous membranes were prepared by freeze extraction (a modification of freeze drying) with ratios 100/0, 80/20, 60/40, 40/60, 20/80, 0/100 in weight. Degradation ...
In vitro 3D culture of human chondrocytes using modified epsilon-caprolactone scaffolds with varying hydrophilicity and porosity

Pérez Olmedilla, Marcos; Lebourg, Myriam Madeleine; Escobar Ivirico, Jorge Luis; Nebot, I.; Garcia Giralt, N.; Gallego-Ferrer, Gloria; Soria, J. M.; Gómez Ribelles, José Luís (SAGE Publications, 2012)

[EN] Two series of 3D scaffolds based on epsilon-caprolactone were synthesized. The pore size and architecture (spherical interconnected pores) was the same in all the scaffolds. In one of the series of scaffolds, made of ...
In Vivo Evaluation of 3-Dimensional Polycaprolactone Scaffolds for Cartilage Repair in Rabbits

Martinez-Diaz, Santos; Garcia-Giralt, Natalia; Lebourg, Myriam Madeleine; Gómez-Tejedor, José Antonio; Vila, Gemma; Caceres, Enric; Benito, Pere; Monleón Pradas, Manuel; Nogues, Xavier; Gómez Ribelles, José Luís; Monllau, Joan Carles (SAGE Publications (UK and US), 2010-03)

Background: Cartilage tissue engineering using synthetic scaffolds allows maintaining mechanical integrity and withstanding stress loads in the body, as well as providing a temporary substrate to which transplanted cells ...
Influence of oxygen levels on chondrogenesis of porcine mesenchymal stem cells cultured in polycaprolactone scaffolds

Ródenas Rochina, Joaquín; Kelly, Daniel John; Gómez Ribelles, José Luís; Lebourg, Myriam Madeleine (John Wiley & Sons, 2017)

[EN] Chondrogenesis of mesenchymal stem cells (MSCs) is known to be regulated by a number of environmental factors, including local oxygen levels. The hypothesis of this study is that the response of MSCs to hypoxia is ...
Robust fabrication of electrospun-like polymer mats to direct cell behaviour

Ballester Beltrán, José; Lebourg., Myriam Madeleine; Capella Monsonís, Héctor; Díaz Lantada, Andrés; Salmerón Sánchez, Manuel (IOP Publishing: Hybrid Open Access, 2014-09)

Currently, cell culture systems that include nanoscale topography are widely used in order to provide cells additional cues closer to the in vivo environment, seeking to mimic the natural extracellular matrix. Electrospinning ...
Scaffold surface modifications and culture conditions as key parameters to develop cartilage and bone tissue engineering implants

Ródenas Rochina, Joaquín (Universitat Politècnica de València, 2015-03-31)

This thesis is focused on the development and evaluation of different hybrid scaffolds for the treatment of injuries in cartilage or bone. These hybrid materials were three-dimensional polycaprolactone macroporous ...