Pérez Ruiz, Raúl; Alonso Ruiz, Rafael; Nuin Plá, Neus Edurne; Andreu Ros, María Inmaculada; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(American Chemical Society, 2011-04-21)
[EN] Three drugs containing the naphthalene (NP) chromophore, namely, naproxen (NPX), propranolol (PPN), and cinacalcet (CIN), but with different affinities toward serum albumins (SAs) and alpha-1-acid glycoproteins (AAGs) ...
Nuin Plá, Neus Edurne; Gómez Mendoza, Miguel; Andreu Ros, María Inmaculada; Marín García, Mª Luisa; Miranda Alonso, Miguel Ángel(American Chemical Society, 2013-01-18)
New photoactive dyads have been synthesized by derivatization of cholic acid (CA) or cholesterol (Ch). These compounds have proven to be efficient tools to monitor incorporation of CA and Ch to mixed micelles (MM) and to ...
Aparici-Espert, Maria Isabel; García-Laínez, G.; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel; Lhiaubet, Virginie Lyria(American Chemical Society, 2018-03)
[EN] In this work, the attention is focused on UVA-photosensitized reactions triggered by a DNA chromophore-containing lesion, namely 5-formyluracil. This is a major oxidatively generated lesion that exhibits an enhanced ...
García -Laínez, Guillermo; Ana M Marínez-Reig; Limones Herrero, Daniel; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel; Andreu Ros, María Inmaculada(Elsevier, 2018)
[EN] Diclofenac (DCF) can cause adverse reactions such as gastrointestinal, renal and cardiovascular disorders;
therefore, topical administration may be an attractive alternative to the management of local pain in order ...
Agúndez, Jose A.G.; García-Martín, Elena; Garcia-Lainez, Guillermo; Miranda Alonso, Miguel Ángel; Andreu Ros, María Inmaculada(Nature Publishing Group, 2020-04-23)
[EN] The human genome is constantly attacked by endogenous and exogenous agents (ultraviolet light, xenobiotics, reactive oxygen species), which can induce chemical transformations leading to DNA lesions. To combat DNA ...
Vayá Pérez, Ignacio; Andreu Ros, María Inmaculada; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel(Royal Society of Chemistry, 2014)
The photooxygenation of model compounds containing the two enantiomers of naproxen (NPX) covalently
linked to histidine (His), tryptophan (Trp) and tyrosine (Tyr) has been investigated by steady state
irradiation, ...
Gómez Mendoza, Miguel; Nuin Plá, Neus Edurne; Andreu Ros, María Inmaculada; Marín García, Mª Luisa; Miranda Alonso, Miguel Ángel(American Chemical Society, 2012-08-30)
The two enantiomers of the nonsteroidal antiinflammatory drug naproxen and of its methyl ester have been selected as representative probes with markedly different hydrophobicity to assess the potential of cholic acid ...
Tamarit-Mayo, Lorena; El Ouardi, Meryem; Andreu Ros, María Inmaculada; Vayá Pérez, Ignacio; Miranda Alonso, Miguel Ángel(The Royal Society of Chemistry, 2021-09-28)
[EN] Gefitinib (GFT) is a tyrosine kinase inhibitor currently used for the treatment of metastatic non-small cell lung cancer. Although it has been suggested that GFT can be phototoxic, there are no systematic studies on ...
Nuin Pla, Neus Edurne; Pérez-Sala, Dolores; Lhiaubet-Vallet, Virginie Lyria; Andreu Ros, María Inmaculada; Miranda Alonso, Miguel Ángel(Frontiers Media SA, 2016)
[EN] Triflusal is a platelet aggregation inhibitor chemically related to acetylsalicylic acid, which is used for the prevention and/or treatment of vascular thromboembolisms, which acts as a prodrug. Actually, after oral ...
Andreu Ros, María Inmaculada; Neshchadin, Dmytro; Rico Inglada, Enrique; Griesser, Markus; Samadi, Abdelouahid; Morera Bertomeu, Isabel María; Gescheidt, Georg; Miranda Alonso, Miguel Ángel(Wiley-VCH Verlag, 2011-07-26)
A thorough mechanistic study has been performed on the reaction between benzophenone (BZP) and a series of 1,4-dienes, including 1,4-cyclohexadiene (CHD), 1,4-dihydro-2-methylbenzoic acid (MBA), 1,4-dihydro-1,2-dimethylbenzoic ...
Andreu Ros, María Inmaculada; Lence, Emilio; González-Bello, Concepción; Mayorga, Cristobalina; Cuquerella Alabort, Maria Consuelo; Vayá Pérez, Ignacio; Miranda Alonso, Miguel Ángel(Frontiers Media SA, 2020-10-30)
[EN] Lapatinib (LAP) is an anticancer drug generally used to treat breast and lung cancer. It exhibits hypersensitivity reactions in addition to dermatological adverse effects and photosensitivity. Moreover, LAP binds to ...
García-Laínez, Guillermo; El Ouardi, Meryem; Moreno, Alejandro; Lence, Emilio; González-Bello, Concepción; Miranda, Miguel Á.; Andreu, Inmaculada(Elsevier, 2023-01)
[EN]
Hepatitis C, a liver inflammation caused by the hepatitis C virus (HCV), is treated with antiviral drugs. In this context, simeprevir (SIM) is an NS3/4A protease inhibitor used in HCV genotypes 1 and 4. It is orally ...
Molins-Molina, Oscar; Bresolí-Obach, Roger; García-Laínez, G.; Andreu Ros, María Inmaculada; Nonell, Santiago; Miranda Alonso, Miguel Ángel; Jiménez Molero, María Consuelo(John Wiley & Sons, 2017-09)
[EN] Singlet oxygen photosensitization (studied by time-resolved near-infrared emission spectroscopy) and in vitro phototoxicity (by means of the 3T3 neutral red uptake assay) have been investigated for the prodrugs ...
Roig Ferrer, Ángela(Universitat Politècnica de València, 2022-12-28)
[ES] El paracetamol (N-4-hidroxifenil-acetamida) es uno de los fármacos más utilizado como analgésico y antipirético a nivel mundial, ya que se encuentra disponible sin necesidad de prescripción médica. Durante la ...
Andreu Ros, María Inmaculada; Palumbo, Fabrizio; Tilocca, Fedele; Morera Bertomeu, Isabel María; Bosca Mayans, Francisco; Miranda Alonso, Miguel Ángel(American Chemical Society, 2011)
[EN] Hydrogen abstraction from the C-7 position of cholesterol (Ch) by triplet excited benzophenone (BZP) exhibits remarkable solvent-dependence in
product studies. Kinetic measurements on the intramolecular version of ...
Andreu Ros, María Inmaculada; Morera Bertomeu, Isabel María; Palumbo, Fabrizio; Sastre Navarro, German Ignacio; Bosca Mayans, Francisco; Miranda Alonso, Miguel Ángel(Royal Society of Chemistry: Chemical Science, 2015)
he influence of non-covalent σ–π orbital interactions on triplet–triplet energy transfer (TTET) through tuning of the donor excitation energy remains basically unexplored. In the present work, we have investigated ...
Tamarit-Mayo, Lorena; El Ouardi, Meryem; Lence, Emilio; Andreu, Inmaculada; González-Bello, Concepción; Vayá Pérez, Ignacio; Miranda Alonso, Miguel Ángel(The Royal Society of Chemistry, 2022-08-24)
[EN] Photosensitization by drugs is directly related with the excited species and the photoinduced processes arising from interaction with UVA light. In this context, the ability of gefitinib (GFT), a tyrosine kinase ...
Neshchadin, Dmytro; Palumbo, Fabrizio; Sinicropi, M. Stefania; Andreu Ros, María Inmaculada; Gescheidt, Georg; Miranda Alonso, Miguel Ángel(Royal Society of Chemistry, 2013)
Cholesterol is one of the most important building blocks of cell membranes. It is also one of the main targets for oxidation via Type I hydrogen abstraction (HA), which leads to a variety of physiological consequences in ...