Hillung, Julia; Cuevas Torrijos, Jose Manuel; Valverde, Sergi; Elena Fito, Santiago Fco(Wiley, 2014-09)
[EN] This study evaluates the extent to which genetic differences among host individuals from the same species condition the evolution of a plant RNA virus. We performed a threefold replicated evolution experiment in which ...
Zwart, Mark Peter; Willemsen, Anouk; Daros Arnau, Jose Antonio; Elena Fito, Santiago Fco(Oxford University Press (OUP): Molecular Biology and Evolution, 2014-01)
[EN] Viruses have evolved highly streamlined genomes and a variety of mechanisms to compress them, suggesting that genome size is under strong selection. Horizontal gene transfer has, on the other hand, played an important ...
Martinez Garcia, Fernando; Elena Fito, Santiago Fco; Daros Arnau, Jose Antonio(American Phytopathological Society, 2013)
Artificial microRNAs (amiRNAs) are the expression products of engineered microRNA (miRNA) genes that efficiently and specifically down-regulate RNAs that contain complementary sequences. Transgenic plants expressing high ...
Carrera Montesinos, Javier; Fernández Del Carmen, María Asunción; Fernández Muñoz, Rafael; Rambla Nebot, Jose Luis; Pons Puig, Clara; Jaramillo Rosales, Alfonso; Elena Fito, Santiago Fco; Granell Richart, Antonio(Public Library of Science, 2012-06-07)
[EN] Considering cells as biofactories, we aimed to optimize its internal processes by using the same engineering principles that
large industries are implementing nowadays: lean manufacturing. We have applied reverse ...
González, Rubén; Butkovic, Anamarija; ELENA FITO, SANTIAGO FCO(Academic Press, 2020)
[EN] Phenotypic plasticity enables organisms to survive in the face of unpredictable environmental stress. Intimately related to the notion of phenotypic plasticity is the concept of the reaction norm that places phenotypic ...
Kassem, Mona A.; Juarez, Miguel; Gómez, Pedro; Mengual, Carmen M.; Sempere, Raquel N.; Plaza, María; Elena Fito, Santiago Fco; Moreno, Aranzazu; Fereres, Alberto; Aranda, Miguel A.(American Phytopathological Society, 2013-11)
[EN] The genetic variability of a Cucurbit aphid-borne yellows virus (CABYV) (genus Polerovirus, family Luteoviridae) population was evaluated by determining the nucleotide sequences of two genomic regions of CABYV isolates ...
Cervera-Benet, Héctor; Elena Fito, Santiago Fco(Oxford University Press (OUP), 2016-01)
[EN] A long-standing observation in evolutionary virology is that RNA virus populations are highly polymorphic, composed by a mixture of genotypes whose abundances in the population depend on complex interaction between ...
Bedhomme, Stephanie; Lafforgue, Guillaume; Elena Fito, Santiago Fco(BioMed Central, 2013-02-19)
[EN] Background: The importance of historical contingency in determining the potential of viral populations to evolve has been largely unappreciated. Identifying the constraints imposed by past adaptations is, however, of ...
Willemsen, A.; Carrasco Jiménez, José Luis; Elena Fito, Santiago Fco.; Zwart, Mark Peter(Nature Publishing Group, 2018)
[EN] Horizontal gene transfer is common among viruses, while they also have highly compact genomes and tend to lose artificial genomic insertions rapidly. Understanding the stability of genomic insertions in viral genomes ...
Willemsen, Anouk; Zwart, Mark Peter; Elena Fito, Santiago Fco.(Springer (Biomed Central Ltd.), 2017)
[EN] Background: Theory suggests that high virulence could hinder between-host transmission of microparasites, and that virulence therefore will evolve to lower levels. Alternatively, highly virulent microparasites could ...
Lafforgue, Guillaume; Martínez, Fernando; Niu, Qi Wen; Chua, Nam Hai; Daros Arnau, Jose Antonio; Elena Fito, Santiago Fco(American Society for Microbiology, 2013-07)
[EN] A drawback of recent antiviral therapies based on the transgenic expression of artificial microRNAs (amiRs) is the ease with
which viruses generate escape mutations. Here, we show two alternative strategies for ...
Hillung, Julia; Elena Fito, Santiago Fco; Cuevas Torrijos, Jose Manuel(BioMed Central, 2013-11-13)
Background: Pipo was recently described as a new ORF encoded within the genome of the Potyviridae family members (PNAS 105: 5897-5902, 2008). It is embedded within the P3 cistron and is translated in the +2 reading frame ...
Elena Fito, Santiago Fco.(Blackwell Publishing, 2017)
[EN] For multihost pathogens, adaptation to multiple hosts has important implications for
both applied and basic research. At the applied level, it is one of the main factors
determining the probability and severity of ...
De la Iglesia Jordán, Francisca; Martinez Garcia, Fernando; Hillung, Julia; Cuevas Torrijos, Jose Manuel; Gerrish, Philip J.; Daros Arnau, Jose Antonio; Elena Fito, Santiago Fco(American Society for Microbiology, 2012)
[EN] A potential drawback of recent antiviral therapies based on the transgenic expression of artificial microRNAs is the ease with which viruses may generate escape mutations. Using a variation of the classic Luria-Delbruck ...
Lalic, Jasna; Elena Fito, Santiago Fco(Nature Publishing Group, 2012-08)
How epistatic interactions between mutations determine the genetic architecture of fitness is of central importance in evolution. The study of epistasis is particularly interesting for RNA viruses because of their genomic ...
Zwart, Mark Peter; Elena Fito, Santiago Fco(Annual Reviews, 2015)
For virus infections of multicellular hosts, narrow genetic bottlenecks during transmission and within-host spread appear to be widespread. These bottlenecks will affect the maintenance of genetic variation in a virus ...
Gallet, Romain; Cooper, Tim F.; Elena Fito, Santiago Fco; Lenormand, Thomas(Genetics Society of America, 2012-01)
[EN] Measuring fitness with precision is a key issue in evolutionary biology, particularly in studying mutations of small effects. It is usually thought that sampling error and drift prevent precise measurement of very ...
Rodrigo Tarrega, Guillermo; Elena Fito, Santiago Fco(Oxford University Press (OUP), 2013)
Robustness is considered a ubiquitous property of living systems at all levels of organization, and small noncoding RNA (sncRNA) is a genuine model for its study at the molecular level. In this communication, we question ...