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Listar por Patrocinador "American Heart Association"

Mostrando ítems 1-7 de 7

Biomechanical consequences of compromised elastic fiber integrity and matrix cross-linking on abdominal aortic aneurysmal enlargement

Weiss, D.; Latorre, Marcos; Rego, B., V.; Cavinato, C.; Tanski, B. J.; Berman, A. G.; Goergen, C. J.; Humphrey, Jay D. (Elsevier, 2021-10-15)

[EN] Abdominal aortic aneurysms (AAAs) are characterized histopathologically by compromised elastic fiber integrity, lost smooth muscle cells or their function, and remodeled collagen. We used a recently introduced mouse ...
Ca2+ Cycling Impairment in Heart Failure Is Exacerbated by Fibrosis: Insights Gained From Mechanistic Simulations

Mora-Fenoll, María Teresa; Ferrero De Loma-Osorio, José María; Gómez García, Juan Francisco; Sobie, Eric A.; Trenor Gomis, Beatriz Ana (Frontiers Media SA, 2018-08-23)

[EN] Heart failure (HF) is characterized by altered Ca2+ cycling, resulting in cardiac contractile dysfunction. Failing myocytes undergo electrophysiological remodeling, which is known to be the main cause of abnormal Ca2+ ...
Differential Modulation of I-K and I-Ca,I-L Channels in High-Fat Diet-Induced Obese Guinea Pig Atria

Martínez-Mateu, Laura; Saiz Rodríguez, Francisco Javier; Aromolaran, Ademuyiwa S. (Frontiers Media SA, 2019-09-25)

[EN] Obesity mechanisms that make atrial tissue vulnerable to arrhythmia are poorly understood. Voltage-dependent potassium (I-K, I-Kur, and I-K1) and L-type calcium currents (I-Ca,I- L) are electrically relevant and ...
In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome

Romero Pérez, Lucia; Trénor Gomis, Beatriz Ana; Yang, Pei-Chi; Saiz Rodríguez, Francisco Javier; Clancy, Colleen E. (Elsevier, 2014-07)

Accurate diagnosis of predisposition to long QT syndrome is crucial for reducing the risk of cardiac arrhythmias. In recent years, drug-induced provocative tests have proved useful to unmask some latent mutations linked ...
In vitro and in vivo cardiac toxicity of flavored electronic nicotine delivery systems

Abouassali, Obada; Chang, Mengmeng; Chidipi, Bojjibabu; Martínez-de-Juan, José L.; Reiser, Michelle; Kanithi, Manasa; Soni, Ravi; McDonald, Thomas V.; Herweg, Bengt; Saiz Rodríguez, Francisco Javier; Calcul, Laurent; Noujaim, Sami F. (American Physiological Society, 2020-11)

[EN] The usage of flavored electronic nicotine delivery systems (ENDS) is popular, specifically in the teen and young adult age-groups. The possible cardiac toxicity of the flavoring aspect of ENDS is largely unknown. ...
Macrophage-Dependent Interleukin-6-Production and Inhibition of I-K Contributes to Acquired QT Prolongation in Lipotoxic Guinea Pig Heart

Chowdhury, Md. Kamrul Hasan; Martínez-Mateu, Laura; Do, Jenny; Aromolaran, Kelly A.; Saiz Rodríguez, Francisco Javier; Aromolaran, Ademuyiwa (MDPI AG, 2021-10)

[EN] In the heart, the delayed rectifier K current, I-K, composed of the rapid (I-Kr) and slow (I-Ks) components contributes prominently to normal cardiac repolarization. In lipotoxicity, chronic elevation of pro-inflammatory ...
Reduced response to IKr blockade and altered hERG1a/1b stoichiometryin human heart failure

Holzem, Katherine M.; Gómez García, Juan Francisco; Glukhov, Alexey V.; Madden, Eli J.; Koppel, Aaron C.; Ewald, Gregory A.; Trénor Gomis, Beatriz Ana; Efimov, Igor R. (Elsevier, 2016-07)

Heart failure (HF) claims 250,000 lives per year in the US, and nearly half of these deaths are sudden and presumably due to ventricular tachyarrhythmias. QT interval and action potential (AP) prolongation are hallmark ...