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A virtual reality bus ride as an ecologically valid assessment of balance: a feasibility study

Gonçalves, A.; Montoya, M. F.; Llorens Rodríguez, Roberto; Bermúdez i Badia, S. (Springer-Verlag, 2021-04-03)

[EN] Balance disorders can have substantial adverse implications on the performance of daily activities and lead to an increased risk of falls, which often have severe negative consequences for older adults. Quantitative ...
Biodistribution of Amino-Functionalized Diamond Nanoparticles. In Vivo Studies Based on (18)F Radionuclide Emission

Rojas, Santiago; Gispert, Juan D.; Martín González, Roberto; Abad, Sergio; Menchón, Cristina; Pareto, Deborah; Víctor, Víctor M.; Alvaro Rodríguez, Maria Mercedes; García Gómez, Hermenegildo; Herance, J. Raúl (American Chemical Society, 2011)

[EN] Nanoparticles have been proposed for several biomedical applications; however, in vivo biodistribution studies to con¿rm their potential are scarce. Nanodiamonds are carbon nanoparticles that have been recently ...
Biointegration of corneal macroporous membranes based on poly(ethyl acrylate) copolymers in an experimental animal model

Alió del Barrio, Jorge L.; Chiesa, Massimo; Gallego Ferrer, Gloria; Garagorri, Nerea; Briz, Nerea; Fernández Delgado, Jorge; Sancho-Tello Valls, María; Carda Botella, Carmen; García-Tuñón, Ignacio; Bataille, Laurent; Rodríguez, Alejandra; Arnalich Montiel, Francisco; Gómez Ribelles, José Luís; Antolinos Turpín, Carmen María; Gómez Tejedor, José Antonio (Wiley: 12 months, 2015-03)

Currently available keratoprosthesis models (nonbiological corneal substitutes) have a less than 75% graft survival rate at 2 years. We aimed at developing a model for keratoprosthesis based on the use of poly(ethyl acrylate) ...
Development of Bioactive Patch for Maintenance of Implanted Cells at the Myocardial Infarcted Site

Castells-Sala, C.; Vallés Lluch, Ana; Soler-Botija, C.; Arnal Pastor, María Pilar; Martínez Ramos, Cristina; Fernandez-Muinos, T.; Mari-Buye, N.; Llucia-Valldeperas, A.; Sanchez, B.; Chachques, J. C.; Bayes-Genis, A.; Monleón Pradas, Manuel; Semino, C. E. (Hindawi Publishing Corporation, 2015)

[EN] Ischemia produced as a result of myocardial infarction might cause moderate or severe tissue death. Studies under development propose grafting stem cells into the affected area and we hypothesize that this mechanism ...
Ecological momentary assessment for chronic pain in fibromyalgia using a smartphone: A randomized crossover study

Garcia-Palacios, A.; Herrero, R.; Belmonte, M.A.; Castilla, D.; Guixeres Provinciale, Jaime; Molinari, G.; Baños, R.M.; Botella, C. (Wiley, 2014-07)

Background Daily diaries are a useful way of measuring fluctuations in pain-related symptoms. However, traditional diaries do not assure the gathering of data in real time, not solving the problem of retrospective assessment. ...
Ejection Fraction by Echocardiography for a Selective Use of Magnetic Resonance After Infarction

Marcos-Garces, Victor; Gavara, Jose; Lopez-Lereu, Maria P.; Monmeneu, Jose V.; Rios-Navarro, Cesar; De Dios, Elena; Pérez, Nerea; Cànoves, Joaquim; Gonzalez, Jessika; Minana, Gema; Nunez, Julio; de la Espriella, Rafael; Santas, Enrique; Moratal, David; Chorro, Francisco J. (Ovid Technologies Wolters Kluwer -American Heart Association, 2020-12)

[EN] Background Cardiac magnetic resonance (CMR) permits robust risk stratification of discharged ST-segment-elevation myocardial infarction patients, but its indiscriminate use in all cases is not feasible. We evaluated ...
Embodiment and Presence in Virtual Reality After Stroke. A Comparative Study With Healthy Subjects

Borrego, Adrián; Latorre, Jorge; Alcañiz Raya, Mariano Luis; Llorens Rodríguez, Roberto (Frontiers Media SA, 2019-10-10)

[EN] The ability of virtual reality (VR) to recreate controlled, immersive, and interactive environments that provide intensive and customized exercises has motivated its therapeutic use after stroke. Interaction and bodily ...
Engineered 3D bioimplants using elastomeric scaffold, self-assembling peptide hydrogel, and adipose tissue-derived progenitor cells for cardiac regeneration

Soler-Botija, Carolina; Bago, Juli R.; Llucia-Valldeperas, Aida; Vallés Lluch, Ana; Castells-Sala, Cristina; Martinez-Ramos, Cristina; Fernandez-Muinos, Teresa; Chachques, Juan Carlos; Monleón Pradas, Manuel; Semino, Carlos E.; Bayes-Genis, Antoni (e-Century Publishing, 2014)

[EN] Contractile restoration of myocardial scars remains a challenge with important clinical implications. Here, a combination of porous elastomeric membrane, peptide hydrogel, and subcutaneous adipose tissue-derived ...
Erbb4 deletion from fast spiking interneurons causes schizophrenia-like phenotypes

del Pino, Isabel; Garcia-Frigola, Cristina; Dehorter, Nathalie; Brotons-Mas, Jorge R.; Alvarez-Salvado, Efren; Martinez de Lagran, Maria; Ciceri, Gabriele; Gabaldón López, María Victoria; Moratal Pérez, David; Dierssen, Mara; Canals, Santiago; Marin, Oscar; Rico, Beatriz (Elsevier (Cell Press), 2013-09-18)

Genetic variation in neuregulin and its ErbB4 receptor has been linked to schizophrenia, although little is known about how they contribute to the disease process. Here, we have examined conditional Erbb4 mouse mutants to ...
Evaluation of a Low-Cost Virtual Reality Surround-Screen Projection System

Gonçalves, Afonso; Borrego, Adrián; Latorre, Jorge; Llorens Rodríguez, Roberto; Bermúdez, Sergi (Institute of Electrical and Electronics Engineers, 2021-06-22)

[EN] Two of the most popular mediums for virtual reality are head-mounted displays and surround-screen projection systems, such as CAVE Automatic Virtual Environments. In recent years, HMDs suffered a significant reduction ...
Facilitated Anion Transport Induces Hyperpolarization of the Cell Membrane That Triggers Differentiation and Cell Death in Cancer Stem Cells

Soto-Cerrato, Vanessa; Manuel-Manresa, Pilar; Hernando, Elsa; Calabuig-Farinas, Silvia; Martinez-Romero, Alicia; Fernandez-Dueñas, Victor; Sahlholm, Kristoffer; Knoepfel, Thomas; Garcia-Valverde, Maria; Rodilla, Ananda M.; Jantus Lewintre, Eloisa; Farras, Rosa; Ciruela, Francisco; Perez-Tomas, Ricardo; Quesada, Roberto (American Chemical Society, 2015-12)

Facilitated anion transport potentially represents a powerful tool to modulate various cellular functions. However, research into the biological effects of small molecule anionophores is still at an early stage. Here we ...
Gait analysis with the Kinect v2: normative study with healthy individuals and comprehensive study of its sensitivity, validity, and reliability in individuals with stroke

Latorre, Jorge; Colomer, Carolina; Alcañiz Raya, Mariano Luis; Llorens Rodríguez, Roberto (Springer (Biomed Central Ltd.), 2019-07-26)

[EN] Background: Gait is usually assessed by clinical tests, which may have poor accuracy and be biased, or instrumented systems, which potentially solve these limitations at the cost of being time-consuming and expensive. ...
Gated Mesoporous Silica Nanoparticles Using a Double-Role Circular Peptide for the Controlled and Target-Preferential Release of Doxorubicin in CXCR4-Expresing Lymphoma Cells

De La Torre, Cristina; Casanova, Isolda; Acosta, Gerardo; Coll Merino, Mª Carmen; Moreno, María José; Albericio, Fernando; Aznar, Elena; Mangues, Ramón; Royo, Miriam; Sancenón Galarza, Félix; Martínez-Máñez, Ramón (Wiley, 2015-02-04)

[EN] B-cell non-Hodgkin s lymphoma (B-NHL) is the most frequent malignant lymphoid neoplasm, which has a high degree of relapse and chemoresist-ance. Thus, strategies to improve currently used therapies are needed. In this ...
Intravenous SPION-labeled adipocyte-derived stem cells targeted to the brain by magnetic attraction in a rat stroke model: An ultrastructural insight into cell fate within the brain

García-Belda, Paula; Prima-García, Helena; Aliena-Valero, Alicia; Castelló-Ruiz, María; Ulloa-Navas, María José; Ten-Esteve, Amadeo; Martí-Bonmatí, Luis; Salom, Juan B.; García-Verdugo, José Manuel; Gil-Perotín, Sara (Elsevier, 2022-01)

[EN] Mesenchymal stem cell therapy after stroke is a promising option investigated in animal models and clinical trials. The intravenous route is commonly used in clinical settings guaranteeing an adequate safety profile ...
Lack of Benefit of Extending Temozolomide Treatment in Patients with High Vascular Glioblastoma with Methylated MGMT

Álvarez-Torres, María del Mar; Fuster García, Elíes; Balaña, Carmen; Puig, Josep; Garcia-Gomez, Juan M (MDPI AG, 2021-11)

[EN] Despite the complete treatment with surgery, chemotherapy and radiotherapy, patients with glioblastoma have a devasting prognosis. Although the role of extending temozolomide treatment has been explored, the results ...
Magnetic Resonance Assessment of Left Ventricular Ejection Fraction at Any Time Post-Infarction for Prediction of Subsequent Events in a Large Multicenter STEMI Registry

Gavara-Doñate, Josep; Marcos-Garces, Victor; Lopez-Lereu, Maria P.; Monmeneu, José V.; Rios-Navarro, César; De Dios, Elena; Pérez, Nerea; Merenciano, Héctor; Gabaldon, Ana; Cànoves, Joaquim; Racugno, Paolo; Bonanad, Clara; Miñana, Gema; Nunez, Julio; Nunez, Eduardo; Moratal, David (John Wiley & Sons, 2022-08)

[EN] Background Magnetic resonance imaging (MRI) is the most accurate imaging technique for left ventricular ejection fraction (LVEF) quantification, but as yet the prognostic value of LVEF assessment at any time after ...
Multi-touch-based assessment of hand mobility, dexterity and function. Preliminary study of validity, reliability and sensitivity to upper limb impairment severity in individuals with stroke.

Latorre, Jorge; Mollà-Casanova, Sara; Salinas, Bárbara; Borrego, Adrián; Alcañiz Raya, Mariano Luis; Colomer, Carolina; Llorens Rodríguez, Roberto (IEEE, 2019-07-24)

[EN] Impairments of the upper limb function are among the most common and disabling sequelae after stroke, and their rehabilitation poses a major challenge for current physical and occupational therapy interventions. While ...
Optimized single-point left ventricular pacing leads to improved resynchronization compared with multipoint pacing

San Antonio, Rodolfo; Guasch, Eduard; González-Ascaso, Ana; Jiménez-Arjona, Rafael; Climent, Andreu M.; Pujol-López, Margarida; Doltra, Adelina; Alarcón, Francisco; Garre, Paz; Liberos Mascarell, Alejandro; Trotta, Omar; Quinto, Levio; Borras, Roger; Arbelo, Elena; Roca-Luque, Ivo; Atienza, Felipe; Brugada, Josep; Fernandez-Aviles, Francisco; Guillem Sánchez, María Salud; Sitges, Marta; Tolosana, José María; Mont, Lluis (Blackwell Publishing, 2021-03)

[EN] Background Multipoint pacing (MPP) in cardiac resynchronization therapy (CRT) activates the left ventricle from two locations, thereby shortening the QRS duration and enabling better resynchronization; however, compared ...
Prognostic value of cardiac magnetic resonance early after ST-segment elevation myocardial infarction in older patients

Gabaldón-Pérez A; Marcos-Garcés, Víctor; Gavara-Doñate, Josep; López-Lereu, María P.; Monmeneu, José V.; Pérez, Nerea; Ríos-Navarro, César; De Dios, Elena; Merenciano-González, Héctor; Cànoves, Joaquim; Racugno, Paolo; Bonanad, Clara; Minana, Gema; Núnez, Julio; Moratal, David (Oxford University Press, 2022-11-02)

[EN] Background older patients with ST-segment elevation myocardial infarction (STEMI) represent a very high-risk population. Data on the prognostic value of cardiac magnetic resonance (CMR) in this scenario are scarce. ...
Reliability and comparison of Kinect-based methods for estimating spatiotemporal gait parameters of healthy and post-stroke individuals

Latorre, Jorge; Llorens Rodríguez, Roberto; Colomer, Carolina; Alcañiz Raya, Mariano Luis (Elsevier, 2018-04-27)

[EN] Different studies have analyzed the potential of the off-the-shelf Microsoft Kinect, in its different versions, to estimate spatiotemporal gait parameters as a portable markerless low-cost alternative to laboratory grade ...