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Listar por Patrocinador "Human Frontier Science Program Organization"

Mostrando ítems 1-16 de 16

A One Precursor One siRNA Model for Pol IV-Dependent siRNA Biogenesis.

Zhai, Jixian; Bischof, Sylvain; Wang, Haifeng; Feng, Suhua; Lee, Tzuu-Fen; Teng, Chong; Chen, Xinyuan; Park, Soo Young; Liu, Linshan; Gallego Bartolomé, Javier; Liu, Wanlu; Henderson, Ian R; Meyers, Blake C.; Ausin, Israel; Jacobsen, Steven E. (Elsevier, 2015-10-08)

[EN] RNA-directed DNA methylation in Arabidopsis thaliana is driven by the plant-specific RNA Polymerase IV (Pol IV). It has been assumed that a Pol IV transcript can give rise to multiple 24-nt small interfering RNAs ...
An allele of Arabidopsis COI1 with hypo- and hypermorphic phenotypes in plant growth, defence and fertility

Dobón Alonso, Albor; Wulff, Brande B Hertel; Canet Perez, Juan Vicente; Fort Rausell, Patrocinio; Tornero Feliciano, Pablo (Public Library of Science, 2013-01)

Resistance to biotrophic pathogens is largely dependent on the hormone salicylic acid (SA) while jasmonic acid (JA) regulates resistance against necrotrophs. JA negatively regulates SA and is, in itself, negatively regulated ...
Co-targeting RNA Polymerases IV and V Promotes Efficient De Novo DNA Methylation in Arabidopsis

Gallego Bartolomé, Javier; Liu, Wanlu; Kuo, Peggy Hsuanyu; Feng, Suhua; Ghoshal, Basudev; Gardiner, Jason; Zhao, Jenny Miao-Chi; Park, Soo Young; Chory, Joanne; Jacobsen, Steven E. (Elsevier, 2019-02-21)

[EN] The RNA-directed DNA methylation (RdDM) pathway in plants controls gene expression via cytosine DNA methylation. The ability to manipulate RdDM would shed light on the mechanisms and applications of DNA methylation ...
Differences in accumulation and virulence determine the outcome of competition during Tobacco etch virus coinfection

Lafforgue, Guillaume; Sardanyes Cayuela, Jose; Elena Fito, Santiago Fco (Public Library of Science, 2011-03-15)

[EN] Understanding the evolution of virulence for RNA viruses is essential for developing appropriate control strategies. Although it has been usually assumed that virulence is a consequence of within-host replication of ...
Dynamics of a plant RNA virus intracellular accumulation: stamping machine versus geometric replication

Martinez, Fernando; Sardanyes Cayuela, Jose; Elena Fito, Santiago Fco; Daros Arnau, Jose Antonio (Genetics Society of America, 2011-07)

[EN] The tremendous evolutionary potential of RNA viruses allows them to thrive despite host defense mechanisms and endows them with properties such as emergence, host switching, and virulence. The frequency of mutant ...
Dynamics of alternative modes of RNA replication for positive-sense RNA viruses

Sardanyes Cayuela, Jose; Martinez, Fernando; Daros Arnau, Jose Antonio; Elena Fito, Santiago Fco (Royal Society, The, 2012-04-07)

[EN] We propose and study nonlinear mathematical models describing the intracellular time dynamics of viral RNA accumulation for positive-sense single-stranded RNA viruses. Our models consider different replication modes ...
Improving the effectiveness of amiRNA-mediated resistance against Turnip mosaic virus by combining two amiRNAs or by targeting highly conserved viral genomic regions

Lafforgue, Guillaume; Martínez, Fernando; Niu, Qi Wen; Chua, Nam Hai; Daros Arnau, Jose Antonio; Elena Fito, Santiago Fco (American Society for Microbiology, 2013-07)

[EN] A drawback of recent antiviral therapies based on the transgenic expression of artificial microRNAs (amiRs) is the ease with which viruses generate escape mutations. Here, we show two alternative strategies for ...
Luria-Delbrück estimation of Turnip mosaic virus mutation rate in vivo

De la Iglesia Jordán, Francisca; Martinez Garcia, Fernando; Hillung, Julia; Cuevas Torrijos, Jose Manuel; Gerrish, Philip J.; Daros Arnau, Jose Antonio; Elena Fito, Santiago Fco (American Society for Microbiology, 2012)

[EN] A potential drawback of recent antiviral therapies based on the transgenic expression of artificial microRNAs is the ease with which viruses may generate escape mutations. Using a variation of the classic Luria-Delbruck ...
Molecular mechanism of action of plant DRM de novo DNA methyltransferases

Zhong, Xuehua; Du, Jiamu; Hale, Christopher J; Gallego Bartolomé, Javier; Feng, Suhua; Vashisht, Ajay A.; Chory, Joanne; Wohlschlegel, James A.; Patel, Dinshaw J.; Jacobsen, Steven E. (Elsevier, 2014-05-26)

[EN] DNA methylation is a conserved epigenetic generegulation mechanism. DOMAINS REARRANGED METHYLTRANSFERASE (DRM) is a key de novo methyltransferase in plants, but how DRM acts mechanistically is poorly understood. ...
Multihost experimental evolution of a plant RNA virus reveals local adaptation and host specific mutations

Bedhomme, Stephanie; Lafforgue, Guillaume; Elena Fito, Santiago Fco (Oxford University Press (OUP), 2012-05)

[EN] For multihost pathogens, adaptation to multiple hosts has important implications for both applied and basic research. At the applied level, it is one of the main factors determining the probability and the severity ...
Quasispecies spatial models for RNA viruses with different replication modes and infection strategies

Sardanyes Cayuela, Jose; Elena Fito, Santiago Fco (Public Library of Science, 2011)

[EN] Empirical observations and theoretical studies suggest that viruses may use different replication strategies to amplify their genomes, which impact the dynamics of mutation accumulation in viral populations and ...
Silicon particles as trojan horses for potential cancer therapy

Fenollosa Esteve, Roberto; Garcia-Rico, Eduardo; Alvarez, Susana; Alvarez, Rosana; Yu, Xiang; Rodriguez, Isabel; Carregal-Romero, Susana; Villanueva, Carlos; Garcia-Algar, Manuel; Rivera-Gil, Pilar; de Lera, Angel R.; Parak, Wolfgang J.; Meseguer Rico, Francisco Javier; Alvarez-Puebla, Ramon A. (BioMed Central, 2014-09-16)

[EN] Background: Porous silicon particles (PSiPs) have been used extensively as drug delivery systems, loaded with chemical species for disease treatment. It is well known from silicon producers that silicon is characterized ...
Tempo and mode of plant RNA virus escape from RNA interference-mediated resistance

Lafforgue, Guillaume; Martínez García, Fernando; Sardanyes Cayuela, Jose; De la Iglesia Jordán, Francisca; Niu, Qi-Wen; Lin, Shih-Shun; Sole, Ricard V.; Chua, Nam-Hai; Daros Arnau, Jose Antonio; Elena Fito, Santiago Fco (American Society for Microbiology, 2011)

A biotechnological application of artificial microRNAs (amiRs) is the generation of plants that are resistant to virus infection. This resistance has proven to be highly effective and sequence specific. However, before ...
The causes of epistasis in genetic networks

Macia, Javier; Sole, Ricard V.; Elena Fito, Santiago Fco (Wiley, 2012-02)

[EN] Epistasis refers to the nonadditive interactions between genes in determining phenotypes. Considerable efforts have shown that, even for a given organism, epistasis may vary both in intensity and sign. Recent comparative ...
The evolutionary genetics of emerging plant RNA viruses

Elena Fito, Santiago Fco; Bedhomme, Stephanie; Carrasco, Purificación; Cuevas, Jose M.; De la Iglesia Jordán, Francisca; Lafforgue, Guillaume; Lalic, Jasna; Prosper Pontones, Angels; Tromas, Nicolas; Zwart, Mark Peter (American Phytopathological Society, 2011-03)

[EN] Over the years, agriculture across the world has been compromised by a succession of devastating epidemics caused by new viruses that spilled over from reservoir species or by new variants of classic viruses that ...
Ultra-deep sequencing analysis of population dynamics of virus escape mutants in RNAi-mediated resistant plants

Martinez Garcia, Fernando; Lafforgue, Guillaume; Morelli, M.; González-Candelas, F.; CHUA, N.H.; Daros Arnau, Jose Antonio; Elena Fito, Santiago Fco (Oxford University Press (OUP), 2012-11)

[EN] Plant artificial micro-RNAs (amiRs) have been engineered to target viral genomes and induce their degradation. However, the exceptional evolutionary plasticity of RNA viruses threatens the durability of the resistance ...