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Mostrando ítems 1-20 de 30

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A Gene Signature Combining the Tissue Expression of Three Angiogenic Factors is a Prognostic Marker in Early-stage Non-small Cell Lung Cancer

Sanmartín, Elena; Sirera Pérez, Rafael; Usó, Marta; Blasco, Ana; Gallach, Sandra; Figueroa, Santiago; Martínez, Nieves; Hernando, Cristina; Honguero, Antonio; Martorell, Miguel; Guijarro, Ricardo; Rosell, Rafael; Jantus-Lewintre, Eloisa; Camps, Carlos (Springer Verlag (Germany), 2014-02)

[EN] Background. Angiogenesis and lymphangiogenesis are key mechanisms for tumor growth and dissemination. They are mainly regulated by the vascular endothelial growth factor (VEGF) family of ligands and receptors. The aim ...
A Study of the Effect of Proinflammatory Cytokines on the Epithelial Cells of Smokers, With or Without COPD

De Diego Damiá, Alfredo; Cortijo Gimeno, Julio; Selma Ferrer, María José; León Fábregas, Montserrat; Almudéver-Folch, Patricia; Milara Payá, Javier (Elsevier, 2011-09)

[EN] Introduction: Cigarette smoke is the main cause of inflammation in COPD. The mechanisms that differentiate smokers who develop COPD are diverse. In this study, we analyzed the presence of cytokines in the respiratory ...
Analysis of the prognostic value of soluble epidermal growth factor receptor plasma concentration in advanced non-small-cell lung cancer patients

Jantus Lewintre, Eloisa; Sirera Pérez, Rafael; Cabrera, Andrea; Blasco, Ana; Caballero, Cristina; Iranzo, Vega; Rosell, Rafael; Camps, Carlos (Elsevier, 2011-09)

[EN] Background: Epidermal growth factor receptor (EGFR) is overexpressed in a variety of epithelial malignancies including lung cancer. A soluble fragment of the EGFR extracellular domain (sEGFR) can be detected in the ...
Bafetinib inhibits functional responses of human eosinophils in vitro

Milara, Javier; Martínez -Losa, Maleles; Sanz, Celia; Almudéver-Folch, Patricia; Peiró, Teresa; Serrano, Adela; Morcillo, Esteban Jesus; Zaragozá, Cristóbal; Cortijo, Julio (Elsevier, 2013-09-05)

[EN] Eosinophils play a prominent role in the process of allergic inflammation. Non-receptor associated Lyn tyrosine kinases generate key initial signals in eosinophils. Bafetinib, a specific Abl/Lyn tyrosine kinase inhibitor ...
CellBase, a comprehensive collection of RESTful web services for retrieving relevant biological information from heterogeneous sources

Bleda, Marta; Tarraga, Joaquín; De María, Alejandro; Salavert, Francisco; García-Alonso, Luz; Celma Giménez, Matilde; Martín Mayordomo, Ainoha; Dopazo, Joaquín; Medina, Ignacio (Oxford University Press (OUP): Policy C - Option B, 2012-07)

During the past years, the advances in high-throughput technologies have produced an unprecedented growth in the number and size of repositories and databases storing relevant biological data. Today, there is more biological ...
Cigarette smoke exposure up-regulates endothelin receptor B in human pulmonary artery endothelial cells: molecular and functional consequences

Milara, J; Ortiz, JL; Juan, G; Guijarro, R; Almudéver-Folch, Patricia; Martorell, M; Morcillo, EJ; Cortijo, J (Blackwell Publishing, 2010-12)

[EN] Background and purpose: Pulmonary arteries from smokers and chronic obstructive pulmonary disease patients show abnormal endothelium-dependent vascular reactivity. We studied the effect of cigarette smoke extract (CSE) ...
Combined VEGF-A and VEGFR-2 concentrations in plasma: diagnostic and prognostic implications in patients with advanced NSCLC

Jantus Lewintre, Eloisa; Sanmartin, Elena; Sirera Pérez, Rafael; Blasco, Ana; Sanchez, Jose Javier; Taron, Miguel; Rosell, Rafael; Camps, Carlos (Elsevier, 2011-11)

Introduction: The vascular endothelial growth factor (VEGF) family of ligands and receptors (VEGFR) play an important role in tumor angiogenesis. Increased expression of angiogenic factors in tumors or in blood is associated ...
Corpus based learning of stochastic, context-free grammars combined with Hidden Markov Models for tRNA modelling

García Gómez, Juan Miguel; Benedí Ruiz, José Miguel; Vicente Robledo, Javier; Robles Viejo, Montserrat (Inderscience, 2005)

[EN] In this paper, a new method for modelling tRNA secondary structures is presented. This method is based on the combination of stochastic context-free grammars (SCFG) and Hidden Markov Models (HMM). HMM are used to ...
Culture of human bone marrow-derived mesenchymal stem cells on of poly(L-lactic acid) scaffolds: potential application for the tissue engineering of cartilage

Izal, Iñigo; Aranda, Pablo; Sanz Ramos, Patricia; Ripalda, Purificacion; Mora, Gonzalo; Granero Molto, Froilan; Deplaine, Harmony; Gómez Ribelles, José Luís; Gallego Ferrer, Gloria; Acosta, Victor; Ochoa, Ignacio; García Aznar, Manuel; Andreu, Enrique J.; Monleón Pradas, Manuel; Doblare Castellano, Manuel; Prosper, Felipe (Springer Verlag, 2013-08)

Due to the attractive properties of poly(l-lactic acid) (PLLA) for tissue engineering, the aim was to determine the growth and differentiation capacity of mesenchymal stromal cells (MSCs) in PLLA scaffolds and their potential ...
Gender and functional CYP2C and NAT2 polymorphisms determine the metabolic profile of metamizole

Martínez, Carmen; Andreu Ros, María Inmaculada; Amo, Gemma; Miranda Alonso, Miguel Ángel; Esguevillas, Gara; Torres, María José; Blanca López, Natalia; Blanca, Miguel; Garcia Martin, Elena; Agúndez, José A.G. (Elsevier, 2014-12-01)

Metamizole is a pain-killer drug that has been banned in some countries because of its toxicity, but it is still used in many countries due to its effective analgesic and antispasmodic properties. Although large variability ...
Gene-environment interaction analysis of redox-related metals and genetic variants with plasma metabolic patterns in a general population from Spain: The Hortega Study

Galvez-Fernandez, Marta; Sanchez-Saez, Francisco; Domingo-Relloso, Arce; Rodríguez-Hernández, Zulema; Tarazona, Sonia; Gonzalez-Marrachelli, Vannina; Grau-Perez, Maria; Morales-Tatay, José M.; Amigo, Nuria; Garcia-Barrera, Tamara; Gomez-Ariza, Jose L.; Chaves, F. Javier; Garcia-Garcia, Ana Barbara; Melero, Rebeca; Tellez-Plaza, Maria (Elsevier, 2022-06)

[EN] Background: Limited studies have evaluated the joint influence of redox-related metals and genetic variation on metabolic pathways. We analyzed the association of 11 metals with metabolic patterns, and the interacting ...
High-rate pacing-induced atrial fibrillation effectively reveals properties of spontaneously occurring paroxysmal atrial fibrillation in humans

Calvo, David; Atienza, Felipe; Jalife, José; Martínez Alzamora, Mª Nieves; Bravo, Loreto; Almendral Garrote, Jesús; González-Torrecilla, Esteban; Arenal, Ángel; Bermejo, Javier; Fernández-Avilés, Francisco; Berenfeld, Omer (Oxford University Press (OUP), 2012-11)

Aims Research on paroxysmal atrial fibrillation (AF) assumes that fibrillation induced by rapid pacing adequately reproduces spontaneously occurring paroxysmal AF in humans. We aimed to compare the spectral properties of ...
Impact of Brain Endothelial Senescence on Neurogenesis: Application of Novel Strategies for Age-Related Senescence Detection

Rojas Vázquez, Sara (Universitat Politècnica de València, 2023-07-03)

[ES] El envejecimiento se concibe como un proceso progresivo de deterioro funcional que se produce a lo largo de la vida. En general, el avance de la edad va acompañado del deterioro de múltiples tejidos, la alteración de ...
Looking for representative fit models for apparel sizing

Vinue, G.; Leon, T.; Alemany Mut, Mª Sandra; Ayala Gallego, Guillermo (Elsevier, 2014-01)

This paper is concerned with the generation of optimal fit models for use in apparel design. Representative fit models or prototypes are important for defining a meaningful sizing system. However, there is no agreement ...
Mechanisms of Fractionated Electrograms Formation in the Posterior Left Atrium During Paroxysmal Atrial Fibrillation in Humans

Atienza, Felipe; Calvo, David; Almendral, Jesús; Zlochiver, Sharon; Grzeda, Krzysztof R.; Martínez Alzamora, María Nieves; González-Torrecilla, Esteban; Arenal, Ángel; Fernández-Avilés, Francisco; Berenfeld, Omer (Elsevier, 2011-03-01)

Objectives: The aim of this paper was to study mechanisms of formation of fractionated electrograms on the posterior left atrial wall (PLAW) in human paroxysmal atrial fibrillation (AF). Background: The mechanisms responsible ...
Microwave versus radiofrequency ablation for the treatment of liver malignancies: a randomized controlled phase 2 trial

Radosevic, Aleksandar; Quesada, Rita; Serlavos, Clara; Sánchez, Juan; Zugazaga, Ander; Sierra, Ana; Coll, Susana; Busto, Marcos; Aguilar, Guadalupe; Flores, Daniel; Arce, Javier; Maiques, Jose Maria; Garcia-Retortillo, Montserrat; Carrion, Jose Antonio; Visa, Laura; Berjano, Enrique; Trujillo Guillen, Macarena (Nature Publishing Group, 2022-01-10)

[EN] Microwave (MWA) and radiofrequency ablation (RFA) are main ablative techniques for hepatocellular carcinoma (HCC) and colorectal liver metastasis (MT). This randomized phase 2 clinical trial compares the effectiveness ...
Modifications in Ventricular Fibrillation and Capture Capacity Induced by a Linear Radiofrequency Lesion

Chorro, Francisco J.; Pelechano Ribes, Francisca; Trapero, Isabel; Ibañez Catala, Xavier; Such-Miquel, Luis; Tormos Ferrando, Álvaro; Guerrero, Juan; Canoves, Joaquin; Mainar, Luis; Millet Roig, José; Alberola, Antonio; Such, Luis (Elsevier, 2012-02)

[EN] Introduction and objectives: An analysis was made of the effects of a radiofrequency-induced linear lesion during ventricular fibrillation and the capacity to capture myocardium through high-frequency pacing. Methods: ...
Non-invasive lightweight integration engine for building EHR from autonomous distributed systems

Angulo Fernández, Carlos; Crespo Molina, Pedro Manuel; Maldonado Segura, José Alberto; Moner Cano, David; Perez Cuesta, Daniel; Abad, Irene; Mandingorra Gimenez, Jesus; Robles Viejo, Montserrat (Elsevier, 2007-12)

[EN] In this paper we describe Pangea-LE, a message-oriented lightweight data integration engine that allows homogeneous and concurrent access to clinical information from disperse and heterogeneous data sources. The engine ...
Noninvasive Localization of Maximal Frequency Sites of Atrial Fibrillation by Body Surface Potential Mapping

Guillem Sánchez, María Salud; Climent, Andreu M.; Millet Roig, José; Arenal, Angel; Fernandez-Aviles, Francisco; Jalife, José; Atienza, Felipe; Berenfeld, Omer (American Heart Association, 2013-01)

Background—Ablation of high-frequency sources in patients with atrial fibrillation (AF) is an effective therapy to restore sinus rhythm. However, this strategy may be ineffective in patients without a significant dominant ...
NUTRARET: Effect of 2-Year Nutraceutical Supplementation on Redox Status and Visual Function of Patients With Retinitis Pigmentosa: A Randomized, Double-Blind, Placebo-Controlled Trial

Olivares-González, Lorena; Salom, David; González-García, Emilio; Hervás-Marín, David; Mejía-Chiqui, Natalia; Melero, Mar; Velasco, Sheyla; Muresan, Bianca Tabita; Campillo, Isabel; Vila-Clérigues, Nieves; Lopez-Briz, Eduardo; Merino-Torres, Juan Francisco; Millán, José María; Soriano del Castillo, José Miguel; Rodrigo, Regina (Frontiers Media S.A., 2022-03-21)

[EN] Oxidative stress plays a major role in the pathogenesis of retinitis pigmentosa (RP). The main goal of this study was to evaluate the effect of 2-year nutritional intervention with antioxidant nutraceuticals on the ...